There is provided acid-resistant capsules, and in particular acid-resistant, vegetarian-based, and/or gelatin-based soft gel capsules and method of manufacturing the soft gel capsule. The soft gel capsule has 30% wt. to 45% wt. water; 15% wt. to 19% wt. glycerol; and a gel mass composition comprising a gelling agent and an alkaline agent. The method of manufacturing the capsule involves: dissolving a gelling polymer into water to form an enteric polymer solution; mixing an acid insoluble polymer with an alkali agent to form a film forming polymer; and adding the film forming polymer to the enteric polymer solution while mixing and heating at 70° C. until a gel mass forms.

An industrially scalable microcapsule, fiber or film forming process and formulations suitable for use in conventional spray drying systems are provided. The one-step spray drying process utilizes formulations of a first ionic polymer, a second ionic polymer with an isoelectric point (pI.sub.2) or acid dissociation constant (pKa.sub.2) that is greater than the isoelectric point (pI.sub.1) or acid dissociation constant (pKa.sub.1) of the first ionic polymer and a volatile base or volatile acid. Volatilization of the volatile base or acid of the spray formulation changes the pH of the solution and changes the charge of the second ionic polymer initiating electrostatic interactions with the first ionic polymer through complex coacervation. Microcapsules formed by the complex coacervation process can stabilize bioactive components as well as control the release of the bioactive components for a variety of applications.

Compounds, compositions, methods, and uses are described for therapeutic deuterated N,N-dimethyltryptamine compounds (e.g., a single compound or a plurality of deuterated N,N-dimethyltryptamine compounds) such as N,N-dimethyltryptamine compounds, α-protio, α-deutero-N,N-dimethyltryptamine compounds, α,α-dideutero-N,N-dimethyltryptamine compounds, and pharmaceutically acceptable salts of these compounds. The deuterated N,N-dimethyltryptamine compound may have an increased half-life compared with the half-life of undeuterated N,N-dimethyltryptamine. For example, a deuterated N,N-dimethyltryptamine compound may be used in therapy and have a Formula (I): ##STR00001## wherein: the ratio of deuterium:protium in the compound is greater than that found naturally in hydrogen; each R.sup.1 is independently selected from H and D; R.sup.2 is selected from CH.sub.3 and CD.sub.3; R.sup.3 is selected from CH.sub.3 and CD.sub.3; each .sup.yH is independently selected from H and D, or a pharmaceutically acceptable salt thereof.

Core shell microcapsules are provided wherein the capsule shell is an interfacial copolymer formed of a gelatin and an isocyanate.

The present invention provides a cannulation device for administering an active agent containing composition to the suprachoroidal space or supraciliary space. The invention provides methods of treatment of an ocular disease or condition accordingly. The invention also provides compositions for use in a method of treatment of an ocular disease or condition for delivery into the suprachoroidal space or supraciliary space.

According to the present disclosure, a method of preparing polymeric microparticles comprising further crosslinking with an organic crosslinking agent after crosslinking with metal ions, polymeric microparticles, medical compositions, cosmetic compositions, medical articles and cosmetic articles comprising the same can be provided.

The invention generally relates to cells and compositions comprising same for use in cell therapy, to methods of obtaining same, and to use of same in cell therapy. In one aspect, the invention provides a method for forming a cell composition from a tissue sample, the method comprising: providing a tissue sample comprising cells; contacting the sample with a polymer in binding conditions, said binding conditions being conditions that enable binding of cells in the sample to the polymer, so that said cells are bound to the polymer; culturing the cells bound to the polymer under conditions and for a time that allows the cell number to increase; providing conditions to induce a phase change of the polymer; thereby forming a cell composition from a tissue sample.

Cannabis-based self-emulsifying products such as self-emulsifying capsules are described herein together with methods for preparing such self-emulsifying products. In at least some embodiments, a self-emulsifying drug delivery system is described.

The present invention provides a method for producing a soft gel capsule comprising uncoated probiotic bacteria, the method comprising gentle mixing the uncoated probiotic bacteria with at least one oil to obtain a soft gel capsule fill material at a temperature in the range of 5 to 15° C., encapsulating the fill material in a soft gel capsule made of a gelatin having a melting point in the range of 11 to 28° C.; and drying the soft gel capsule in one or more steps to a water activity of at the most 0.25 at a temperature of at the most 25° C., as well as soft gel capsules produced by this method. The present invention further provides a soft gel capsule comprising dried, uncoated, non-spore-forming probiotic bacteria wherein the soft gel capsule comprises at least E+09 viable bacteria after 24 months of storage at 25° C., e.g. at least 2 E+09 viable bacteria after 12 months of storage at 25° C.

An object of the present invention is to provide a technique for delaying disintegration of a capsule by blending a certain component in a core of the capsule, and to increase the degree of freedom in capsule design. The present invention relates to a delayed disintegration-type seamless capsule that is a seamless capsule including a core, one or more intermediate layers formed on the core, and an outermost layer formed on the intermediate layers, wherein the core contains an active substance, an amphoteric surfactant, and a fat having a melting point of 40° C. or more, at least one layer of the intermediate layers contains a fat having a melting point of 45° C. or more, and the outermost layer contains a water-soluble natural polymer. The present invention also relates to a method for producing the same.