Provided herein are fluorinated compounds having chemical structures: (I) where n is 0 or greater, or (II) where m and n are 0 or greater, or an amino acid, a soluble polymer, an oligo(ethylene glycol), a poly(ethylene glycol), or a carbohydrate each fluorinated with perfluorocarbons having the chemical structure (III) where n is 0 or greater. These fluorinated compounds are utilized in contact lenses to impart lipid-resistant, protein-resistant and biofouling-resistant properties, thus reducing discomfort and infection caused by contact lens wear without changing its transmission characteristics. Also provided is an ophthalmic drug delivery system comprising at least one of the compounds described above embedded in the contact lens and a kit to incorporate the ophthalmic into a contact lens. Methods for incorporating these compounds onto a contact lens without affecting transparency and for use in treating an ophthalmologic-associated condition are provided. ##STR00001##

Provided herein are fluorinated compounds having chemical structures: (I) where n is 0 or greater, or (II) where m and n are 0 or greater, or an amino acid, a soluble polymer, an oligo(ethylene glycol), a poly(ethylene glycol), or a carbohydrate each fluorinated with perfluorocarbons having the chemical structure (III) where n is 0 or greater. These fluorinated compounds are utilized in contact lenses to impart lipid-resistant, protein-resistant and biofouling-resistant properties, thus reducing discomfort and infection caused by contact lens wear without changing its transmission characteristics. Also provided is an ophthalmic drug delivery system comprising at least one of the compounds described above embedded in the contact lens and a kit to incorporate the ophthalmic into a contact lens. Methods for incorporating these compounds onto a contact lens without affecting transparency and for use in treating an ophthalmologic-associated condition are provided. ##STR00001##

Described herein are pharmaceutical compositions and contact lens solutions comprising an Acanthamoeba encystation inhibitor such as a cationic quaternary ammonium compound and a physiologically or pharmaceutically acceptable carrier or excipient, optionally in combination with an Acanthamoeba cytotoxic agent such as an alkylphosphocholine. Such compositions are suitable for use in the treatment of Acanthamoeba infection or the prevention or treatment of Acanthamoeba keratitis.

A contact lens cleaner and a method for protein removal and sterilization by electrophoresis dissociation are disclosed. The contact lens cleaner comprises a lens cleaning tank (10), two electrophoresis dissociation probes (20) are arranged in the lens cleaning tank (10) opposite each other, and the electrophoresis dissociation probes (20) are electrically connected to a circuit power supply. The lens cleaning tank (10) is filled with an electrolyte solution; a lens to be cleaned is placed in the lens cleaning tank (10); and a switch is turned on, and the two electrophoresis dissociation probes (20) in the lens cleaning tank (10) form an anode and a cathode. There are lacrimal proteins on the surface of the lens to be cleaned, the lacrimal proteins are charged in the solution, and the charged lacrimal proteins move to the electrode opposite to the electrical property thereof in the cleaning tank (10) according to the phenomenon of electrophoresis. The electrolyte solution reacts chemically in the cleaning tank (10) to produce hypochlorite having a strong oxidizing property, and the hypochlorite can degrade the lacrimal proteins, and also can sterilize and disinfect.

A contact lens cleaner and a method for protein removal and sterilization by electrophoresis dissociation are disclosed. The contact lens cleaner comprises a lens cleaning tank (10), two electrophoresis dissociation probes (20) are arranged in the lens cleaning tank (10) opposite each other, and the electrophoresis dissociation probes (20) are electrically connected to a circuit power supply. The lens cleaning tank (10) is filled with an electrolyte solution; a lens to be cleaned is placed in the lens cleaning tank (10); and a switch is turned on, and the two electrophoresis dissociation probes (20) in the lens cleaning tank (10) form an anode and a cathode. There are lacrimal proteins on the surface of the lens to be cleaned, the lacrimal proteins are charged in the solution, and the charged lacrimal proteins move to the electrode opposite to the electrical property thereof in the cleaning tank (10) according to the phenomenon of electrophoresis. The electrolyte solution reacts chemically in the cleaning tank (10) to produce hypochlorite having a strong oxidizing property, and the hypochlorite can degrade the lacrimal proteins, and also can sterilize and disinfect.

Provided herein are fluorinated compounds having chemical structures: (I) where n is 0 or greater, or (II) where m and n are 0 or greater, or an amino acid, a soluble polymer, an oligo(ethylene glycol), a poly(ethylene glycol), or a carbohydrate each fluorinated with perfluorocarbons having the chemical structure (III) where n is 0 or greater. These fluorinated compounds are utilized in contact lenses to impart lipid-resistant, protein-resistant and biofouling-resistant properties, thus reducing discomfort and infection caused by contact lens wear without changing its transmission characteristics. Also provided is an ophthalmic drug delivery system comprising at least one of the compounds described above embedded in the contact lens and a kit to incorporate the ophthalmic into a contact lens. Methods for incorporating these compounds onto a contact lens without affecting transparency and for use in treating an ophthalmologic-associated condition are provided.

Provided herein are fluorinated compounds having chemical structures: (I) where n is 0 or greater, or (II) where m and n are 0 or greater, or an amino acid, a soluble polymer, an oligo(ethylene glycol), a poly(ethylene glycol), or a carbohydrate each fluorinated with perfluorocarbons having the chemical structure (III) where n is 0 or greater. These fluorinated compounds are utilized in contact lenses to impart lipid-resistant, protein-resistant and biofouling-resistant properties, thus reducing discomfort and infection caused by contact lens wear without changing its transmission characteristics. Also provided is an ophthalmic drug delivery system comprising at least one of the compounds described above embedded in the contact lens and a kit to incorporate the ophthalmic into a contact lens. Methods for incorporating these compounds onto a contact lens without affecting transparency and for use in treating an ophthalmologic-associated condition are provided.

An apparatus for sanitizing a point-of-contact surface may include a housing configured to be affixed about at least a portion of said point of contact. The housing may have an interior in or through which the point of contact may be accessed and an anterior opening for access to the interior. The apparatus may further include one or more sources of a sanitizing agent, such as germicidal light, configured to direct the sanitizing agent toward a location where at least a portion of the point-of-contact surface may be disposed. One or more of an anterior dome, an inner surface, and a posterior surface may also be configured to reflect the sanitizing agent toward the location where at least a portion of the point-of-contact surface may be disposed.

An apparatus for sanitizing a point-of-contact surface may include a housing configured to be affixed about at least a portion of said point of contact. The housing may have an interior in or through which the point of contact may be accessed and an anterior opening for access to the interior. The apparatus may further include one or more sources of a sanitizing agent, such as germicidal light, configured to direct the sanitizing agent toward a location where at least a portion of the point-of-contact surface may be disposed. One or more of an anterior dome, an inner surface, and a posterior surface may also be configured to reflect the sanitizing agent toward the location where at least a portion of the point-of-contact surface may be disposed.

The present invention is generally related to a lens care system and method for disinfecting and cleaning contact lenses. A lens care system or method of the invention is based on electrolysis of an aqueous chloride solution for generating germicide species (e.g., chlorine, hypochlorous acid, hypochlorite, or combinations thereof) and subsequent in-situ electrolysis of hypochlorous acid or hypochlorite in the aqueous solution for neutralizing the generated germicide species.