A continuous differential-pressure steam sterilization system for a powder, and belongs to the field of material sterilization includes: a superheated steam generation system, a steam pressure and flow rate control system, a quantitative feeding system, an instantaneous differential-pressure sterilization system, a dust explosion suppression system, a sterile cooling system, a primary gas-solid separation system, a secondary gas-solid separation system, a sterile storage system, a steam recovery and reheating system, and a condensate recovery system. The continuous differential-pressure steam sterilization system shortens the thermal contact time and mainly accumulates the heat on the surface of the powder, rather than in the center of the powder, which reduces the damage to the nutritional quality of the powder. Comprehensive treatment methods such as superheated steam, temperature compensation and non-sticky inner lining are adopted to reduce the problem of powder binding, agglomeration, and even blocking in the pipe of the system.

The mitigation of indoor pathogens comprises quantifying, using a bio-aerosol monitoring system, the amount of total pathogens in the air and on surfaces within an indoor environment. Moreover, the process comprises sanitizing the indoor environment with portable equipment to stabilize the indoor environment when it is determined that the indoor environment is contaminated. Also, the process comprises installing a purification device within a contaminated area of the indoor environment, and monitoring continuously, the indoor environment after sanitizing, for pathogens. Still further, the process comprises releasing a purifying agent upon detecting pathogens in the indoor environment, and providing periodic maintenance to the purification device.

The present invention provides the sterilization of an ophthalmic composition comprising timolol or salt thereof optionally with pharmaceutically acceptable agent(s) wherein the sterilization is achieved through aseptic filtration technique. Further the present invention provides the sterilization process by optimising the process parameters by varying the heating time at a temperature to control the viscosity of the ophthalmic composition of present invention through aseptic filtration technique wherein the filtration is done under aseptic condition through 0.45 μm clarification pre-filter followed by 0.2μ sterilizing grade filter. The process is simple and economical.

Provided is an antiviral filter medium. An antiviral filter medium according to one embodiment of the present invention includes a first member provided with an antiviral coating layer formed of fibers and including, on part or all of the outer surface of the fibers, an antiviral fusion protein in which an antiviral motif is bound to an adhesive protein. Accordingly, the antiviral filter medium exhibits antiviral properties, is excellent in filtration efficiency and ventilation amount (or flow rate), and has low pressure loss. In addition, the antiviral filter medium is characterized in that the coating layer exhibiting antiviral properties retains adhesiveness for a long period of time after being attached to the surface. Moreover, the antiviral filter medium can retain antiviral activity for a long time without loss of the antiviral activity due to external conditions during production, storage, and use.

Disclosed is a method for filtering a fibrinogen composition, comprising the following steps: a) purifying the fibrinogen composition by chromatographic purification using an elution buffer comprising arginine; b) optionally, at least one step of filtering the fibrinogen composition obtained by chromatographic elution in step a), on a filter having a pore size of between 0.08 μm and 0.22 μm, c) filtering the fibrinogen composition obtained by chromatographic elution in step a), or optionally obtained in step b), on a symmetrical filter having a pore size of between 15 nm and 25 nm, and preferably between 18 nm and 22 nm, and d) recovering the resulting fibrinogen solution, the filtering method being carried out without adding arginine after step a), at a high capacity and without a prior freezing and/or thawing step.

Systems and methods of generating and regenerating peritoneal dialysate are provided. The systems and methods use a dialysate regeneration module, a sterilization module and concentrates to prepare peritoneal dialysate from used peritoneal dialysate or source water. An optional integrated cycler for direct infusion of the generated peritoneal dialysate is included. Optional dialysate storage containers are provided for storage of the peritoneal dialysate prior to use.

Systems and methods of generating peritoneal dialysate are provided. The systems and methods use a water purification module, a sterilization module and concentrates to prepare a bolus of peritoneal dialysate from source water for use with an non-integrated cycler.

Disclosed herein are methods of making sterilized ciprofloxacin compositions. In some embodiments, the method includes the steps of: (a) forming an aqueous suspension comprising ciprofloxacin particles; (b) heating the aqueous suspension comprising ciprofloxacin particles at a temperature range of from about 100° C. to about 120° C.; and (c) allowing the aqueous suspension comprising ciprofloxacin particles to cool down. Also described herein are otic formulations containing ciprofloxacin formed by the disclosed methods, and therapeutic use of such otic formulation for providing sustained release of ciprofloxacin into the ear for treating various otic disorders and conditions.

The present invention offers infectious virus mitigation apparatus that utilize one or more 3-dimensional porous metal substrate that impart virus mitigation effect. Fluid that contains or may contain infectious virus traverses through said substrate to achieve virus mitigation effect. Additional virus mitigation effect can be achieved by subjecting said virus mitigation apparatus to suitable wavelength(s) of light that enhance total virus mitigation effect and/or utilizing contoured cover glazing to induce fluid dynamics that can enhance total virus mitigation effect per pass of said fluid through said apparatus. The utility includes a wide variety of practical uses such as filtration of air, water, blood, and other fluids that contain or may contain infectious virus such as coronavirus.

A device and process to inactivate viruses and kill living bacteria using the available techniques like UV irradiation, heat, filtration, and/or chemical treatment, individually or all at once to achieve the best results. The operation of the invention could be programmed/controlled using a remote controller/programmer. The invention could be used in spaces occupied by humans or when humans are not present. When humans are not present it uses mainly UV irradiation, and when humans are present it circulates the air to be disinfected through a protective enclosure. In some applications using UV disinfection, the device can circulate and disinfect the air inside it, while irradiating the UV irradiations to other parts of the space to disinfect them. One embodiment of the device is similar to a mask, not just to collect the viruses and bacteria, but also, to inactivate the viruses and kill the bacteria. The invention will make indoor places very safe and safer than outdoors, because the indoor could be disinfected as a controlled enclosed space, while the outdoor is practically impossible to disinfect. Which will allow people to live better life without fears of contracting or spreading the viruses now or in the future. The invention is easy to install, operate, maintain, clean, and highly effective.