The present disclosure relates to methods for extending the shelf life of a sterile ophthalmic pharmaceutical composition.

Disclosed herein are cohesive soft tissue fillers, for example, dermal and subdermal fillers, based on hyaluronic acids and pharmaceutically acceptable salts thereof. In one aspect, hyaluronic acid-based compositions described herein include a therapeutically effective amount of at least one anesthetic agent, for example, lidocaine. The present hyaluronic acid-based compositions including lidocaine have an enhanced stability and cohesivity, relative to conventional compositions including lidocaine, for example when subjected to sterilization techniques or when stored for long periods of time. Methods and processes of preparing such hyaluronic acid-based compositions are also provided.

A brake disc having a first component made of a first material, a braking track configured to cooperate with brake pads, and a second component made of a second material and having (i) a radially inner annular portion for coupling with a hub of a bicycle wheel and (ii) a plurality of radially outer portions for connecting to said first component at a respective plurality of connection portions of said first component. The first component comprises a plurality of connection arms that extend from said braking track towards said predetermined rotation axis (X) and that are distinct from said plurality of connection portions, wherein at least one of said connection arms of said first component and at least one of said radially outer connection portions of said second component are coupled together through at least one shape coupling.

A continuous differential-pressure steam sterilization system for a powder, and belongs to the field of material sterilization includes: a superheated steam generation system, a steam pressure and flow rate control system, a quantitative feeding system, an instantaneous differential-pressure sterilization system, a dust explosion suppression system, a sterile cooling system, a primary gas-solid separation system, a secondary gas-solid separation system, a sterile storage system, a steam recovery and reheating system, and a condensate recovery system. The continuous differential-pressure steam sterilization system shortens the thermal contact time and mainly accumulates the heat on the surface of the powder, rather than in the center of the powder, which reduces the damage to the nutritional quality of the powder. Comprehensive treatment methods such as superheated steam, temperature compensation and non-sticky inner lining are adopted to reduce the problem of powder binding, agglomeration, and even blocking in the pipe of the system.

A powder sterilization method for sterilizing powder, in particular an active pharmaceutical ingredient in powder form or food in powder form, using fluid vapor, in particular steam. According to the invention, the fluid vapor is applied to the powder in an evacuated treatment chamber (3), in particular it is applied to the powder during its free fall along a drop section (7), in particular in countercurrent.

An assembly for redirecting light emitted by an end-emitting optical fiber into an inner lumen of a body is provided. According to one implementation, the body includes one or more surfaces disposed on or in the body onto which the light is configured to impinge when the end emitting optical fiber is activated, the one or more surfaces being configured to alter the trajectory of the light so that the light is directed to impinge on a light reflector of a cap removably attached to the body, the light reflector of the cap being configured to redirect the light distally into the inner lumen of the body.

The present disclosure relates to a pharmaceutical composition for providing phosphorus to an adult or pediatric patient, wherein the composition is an aqueous solution of sodium glycerophosphate which by virtue of an improved process for producing the active pharmaceutical ingredient and the pharmaceutical composition is characterized by a low amount of free phosphate, a low amount of SGP-related substances and by a low amount of aluminum. The pharmaceutical composition is used in clinical nutrition, preferably in the preparation of nutritional formulations by compounding. The compositions can further be used for preventing or correcting phosphorus deficiency (hyperphosphatemia) in said adult or pediatric patients.

Methods, apparatuses, systems, and implementations for inductive heating of a foreign metallic implant are disclosed. A foreign metallic implant may be heated via AMF pulses to ensure that the surface of the foreign metallic implant heats in a uniform manner. As the surface temperature of the foreign metallic implant rises, acoustic signatures may be detected by acoustic sensors that may indicate that tissue may be heating to an undesirable level approaching a boiling point. Once these acoustic signatures are detected, the AMF pulses may be shut off for a time period to allow the surface temperature of the implant to cool before applying additional AMF pulses. In this manner, the surface temperature of a foreign metallic implant may be uniformly heated to a temperature adequate to treat bacterial biofilm buildup on the surface of the foreign metallic implant without damaging surrounding tissue. The AMF pulse treatment can be combined with an antibacterial/antimicrobial treatment regimen to reduce the time and/or antibacterial dosage amount needed to remove the biofilm from the metallic implant.

An apparatus for heat treatment of a product, in particular food product, and especially food product in a container such as a can, bottle or plastic pouch is disclosed. The apparatus comprises an unloading and loading section, a first treatment section having an inner wall defining a processing volume within which product is heated, a transfer section and a second treatment section having an inner wail defining a processing volume within which product is cooled, multiple carriers for retaining product during treatment designed to provide multi-stage pressure reductions that collectively reduce the maximum over-pressure within the apparatus to ambient pressure and thereby eliminate the need for sealable pressure doors or gate valves. The loading section incorporates means of linear movement of said product carriers in a continuous fashion. The carriers includes elements to create cavities between or within successive carriers and a plurality of throughapertures to force heat treatment fluid into direct contact with product as it flows from over ambient to ambient pressure. A heat exchanger recovers energy from cooling product and continuously re-applies that energy to heat product.

In a first aspect, the present invention relates to a process for producing a stable, injectable solution with low content of noradrenaline, which includes dissolving noradrenaline and optionally an excipient in deoxygenated or degassed water, filtrating the resulting noradrenaline solution in a nitrogen current, distributing the solution in a nitrogen current, and sterilization, preferably hot. The invention further provides a stable, injectable solution with low content of noradrenaline, substantially free of anti-oxidizing and preservative agents, as well as uses thereof in the medical and pharmaceutical fields.