An irradiation device includes a fluid treatment chamber having first and second opposing sides configured to receive a biological fluid container therebetween, and at least one light source disposed adjacent at least one of the first and second sides of the fluid treatment chamber. The at least one light source includes a light guide having a front planar surface that defines in part the at least one of the first and second sides of the fluid treatment chamber, and at least one light emitting diode (LED) disposed at an edge of the light guide outside the fluid treatment chamber and configured to direct light into the light guide. The light guide has a back surface opposite the front planar surface, the back surface with one or more reflectors that depend into the light guide in the direction of the front surface.

The disclosure relates to uses, methods and compositions for the inactivation of pathogens in biological compositions, using a glycol as a pathogen inactivating agent.

Disclosed herein are a sterilization module and a sterilization system including the same. The sterilization module includes a light source emitting germicidal light to kill pathogens in living cells. The living cells may include living cells and the pathogens. In addition, the germicidal light may be light in a wavelength band capable of ensuring a viability of 70% or more for the normal cells and a viability of less than 70% for the pathogens.

Provided are systems and methods for treating a biological fluid, e.g., to inactivate pathogens.

Provided are systems and methods for treating a biological fluid, e.g., to inactivate pathogens.

A method and device for the remote eradication of pathogens comprising a light source for emitting UV light in the pathogen killing wave length range, and a tangible transmission medium, which is at least initially resistant to degradation by the UV light. An optical interface between the UV light source and the tangible transmission medium is provided whereby the emitted UV light is collected from the light source and transmitted through the tangible transmission medium, whereby UV light emitted from the tangible transmission medium and directed against a pathogen in proximity thereto is at a power level sufficient to substantially effectively kill the pathogen within a reasonable period of time. The device is used for sanitization of biopsy channels of endoscopes and for treating of pathogens within humans and animals.

A method of sanitizing liquid for use in a medical device, the method comprising the steps of providing a medical device defining a water circuit with a volume of liquid, sensing the temperature of the volume of liquid with a sensor, heating the volume of liquid from an initial temperature to exceed a threshold temperature, maintaining the volume of liquid above the threshold temperature, determining a time-temperature value for the volume of liquid periodically once the threshold temperature has been exceeded, calculating a cumulative time-temperature value and providing an output signal once the cumulative time-temperature value has reached a level indicative of a sanitizing dose. A medical device and a liquid sanitizer are also disclosed.

Methods and compositions for the prevention or reduction of platelet transfusion associated complications are provided. The subject methods include modifying donor whole blood or platelets prior to transfusion to prevent or reduce alloimmune platelet refractoriness.

The present disclosure provides apparatuses and systems for delivering a measureable absorbed-dose of a gaseous activating agent to a fluid including a biological liquid and/or cells. The apparatuses or systems include a gas-fluid contact device configured to controllably rotate or oscillate a control member having an interior surface in contact with the fluid and a control system configured to control rotation or oscillation of the contact member by the gas-fluid contact device. In some embodiments, the control system is further configured to control absorption of the gaseous activating agent by the fluid. The present disclosure also provides methods of treating a fluid including a biological liquid or cells with a gaseous activating agent to controllably activate the fluid.

A sterilization method includes irradiating flexible bags, in particular, bags of the type that can contain solutions of human plasma proteins for therapeutic use. The sterilization method includes electron beam irradiation. An in-line method for filling flexible bags of the type that can contain solutions of human plasma proteins for therapeutic use can use the sterilization method.