Novel, lubricious coatings for medical devices are disclosed. The coatings provide improved lubricity and durability and are readily applied in coating processes a low temperatures that do not deform the device. The present invention is also directed to a novel platinum catalyst for use in such coatings. The catalyst provides for rapid curing, while inhibiting cross-linking at ambient temperatures, thereby improving the production pot life of the coatings.

Provided are orthopedic implants and systems and kits containing orthopedic implants that include biodegradable polymer thin films containing an antimicrobial agent, wherein the implants produce an effective zone of inhibition around a periphery of the surface of the implant and do not produce a loss of release torque between interlocking implant components.

In this work, we investigated the blood platelet adhesion and activation of truly superhemophobic surfaces and compared them with that of hemophobic surfaces and hemophilic surfaces. Our analysis indicates that only those superhemophobic surfaces with a robust Cassie-Baxter state display significantly lower platelet adhesion and activation. The understanding gained through this work will lead to the fabrication of improved hemocompatible, superhemophobic medical implants.

A swellable polymer based fibre and method of preparing the same for use as, for example, a wound dressing. The fibres may be formed from an aqueous dope solution containing a primary polymer and povidone-iodine (PVP-I). The aqueous dope solution is spun or extruded into a coagulation bath via a multi-hole spinneret head to form a multifilament fibre.

The present invention is directed to suturing systems having a needle, an elongated flexible suture having a connecting end attached to a said needle and an opposing free end and at least one elongated external beneficial filament that is attached to said needle or attached to said suture at the connecting end. The beneficial filament has a smaller cross-sectional area and lower mechanical strength than the suture and contains a medicant.

Novel, lubricious antimicrobial coatings for medical devices are disclosed. The coatings provide improved lubricity and durability and are readily applied in coating processes at low temperatures that do not deform the device and preserves the antimicrobial effectiveness of the antimicrobial agent. The present invention is also directed to a novel platinum catalyst for use in such coatings. The catalyst provides for rapid curing, while inhibiting cross-linking at ambient temperatures, thereby improving the production pot life of the coatings.

The present disclosure provides a coating applicator operable to apply a coating of a therapeutic agent upon an object comprising an openable and sealable device compartment, a therapeutic agent positioned in communication with the device compartment, an atomizer operable to atomize the therapeutic agent, and a source of vacuum in communication with the device compartment. The coating applicator may further comprise a drier, and the drier may comprise an arrangement to operate the source of vacuum for a time sufficient to promote drying of applied therapeutic agent. Deposition of the atomized therapeutic agent may be promoted by contacting the atomized therapeutic agent while the object is in a chilled condition and by contacting the object with atomized therapeutic agent while the atomized therapeutic agent is in a heated condition. Related methods are also disclosed.

A method of reducing surgical site infection (SSI), using a coated medical device having a tissue penetrating surface and an abradable coating on the medical device comprising at least one antimicrobial agent in the coating.

The invention relates to the field of polymers, in particular to polymer systems based on polyurethane (PU) having abroad spectrum biocidal activity and the use thereof in the manufacture of biocidal products. Provided is a process to provide a biocidal polyurethane-iodin e (PU-I) complex, comprising (i) dissolving at least one iodine source into one or more raw materials used for preparing the desired polyurethane (PU) to obtain a single phase iodine system, followed by (ii) conducting a PU polymerization reaction in the presence of the single phase iodine system to generate a biocidal PU-I complex in situ.

An embolic material contains at least one type of polymer and a liposoluble contrast medium. A method for producing an embolic material includes extruding a raw material that is in a molten state into a solvent, and cooling the raw material so as to solidify the raw material. The raw material contains a polymer and a liposoluble contrast medium.