A wound covering is provided that comprises a substrate and vitamin D, or analogues or metabolites thereof, embedded in the substrate. Methods of making a wound covering are also provided and include the steps of providing a solution that includes a polymer; adding vitamin D, or analogues or metabolites thereof, to the solution to form a mixture; and forming one or more fibers from the mixture that are then embedded with the vitamin D, or analogues or metabolites thereof. Methods of treating a subject are further provided and include the step of applying a wound covering including one or more fibers embedded with vitamin D, or analogues or metabolites thereof, to a site on a subject.

The present inventors have developed printable collagen bioinks using unmodified type I collagen with mechanical and structural properties that facilitate application to tissue in a structured form. In particular, the compositions of the present invention may be used to apply collagen gels to tissue (e.g. eye) using two- or three-dimensional (extrusion) bioprinting techniques.

Disclosed are apparatus, compositions, and methods for promoting regeneration of tissue on a subject such as a wounded, damaged, or injured appendage, or within a subject such as a wounded, damaged, or injured organ. The disclosed apparatus, composition, and methods include or utilize wearable sleeves and regenerative compositions.

Compositions may include a therapeutic that is released from the composition to treat any number of ailments or conditions (e.g., pain, infection, cancer, osteoporosis) or to help accelerate local tissue regeneration (e.g., growth hormone, bone morphogenic protein) or to assist with surgical or therapeutic treatment (e.g., imaging modality), or any of a combination thereof.

The present disclosure relates to a polycaprolactone microsphere containing vitamin C, a filler including the same and a preparation method therefor. Provided is a polycaprolactone microsphere filler obtained by encapsulating vitamin C in polycaprolactone microspheres, which, when injected into a living body, exhibits a rapid collagen formation effect as well as a high tissue restoration property and maintains the effects for a long period of time, thereby showing excellent restoration or volume expansion or wrinkle improvement properties of soft tissues such as cheeks, breasts, nose, lips, and buttocks and reducing wrinkles.

Disclosed herein is a drug-coated balloon catheter including: a hub; a soft tip; a tube which connects the hub and the soft tip and is formed of a material having higher rigidity than the soft tip; and a balloon which is mounted on the tube and coated with a drug on the surface, wherein the tube includes: a guide lumen which allows a guide wire to be movable, the guide wire being inserted into a blood vessel via the hub; and an injection lumen into which a contrast medium is injected, the contrast medium being injected into the balloon through the hub or discharged therefrom, wherein the injection lumen includes: a flow center which is a portion corresponding to a width of the guide lumen; and a pair of bend supports which is extended beyond both end portions of the guide lumen on both sides of the flow center and deformed in response to bending of the tube, and the injection lumen has a cross-sectional area more than a half of a cross-sectional area of the guide lumen.

A hyaluronic acid-based aqueous gel including crosslinked hyaluronic acid and from 30 to 70% by mass with respect to the total mass of hyaluronic acid, of a water-soluble hyaluronic acid. A method for preparing an aqueous gel having at least a crosslinked hyaluronic acid and at least an uncrosslinked hyaluronic acid. Also an aqueous gel obtainable by the method compositions, a cosmetic and/or dermatological composition including the aqueous gels, and a kit comprising a pre-filled syringe comprising the aqueous gel or said composition. These gels and compositions are useful in particular for treating an alteration in the surface appearance of the skin and/or for augmenting and/or filling soft tissue.

Disclosed is the preparation of injectable collagen suspensions, to the method for preparing the suspensions, and to the uses thereof, particularly for forming dense collagen matrices.

The present disclosure provides biocompatible and bioresorbable devices for tissue repair and regeneration and delivery of an active agent across a biological barrier comprising silk fibroin and hyaluronic acid.

Provided is a thermosensitive phosphazene-based polymer including an amino acid ester moiety, a polyethyleneglycol moiety, and a moiety including a sulfate group linked directly or by a linker in a predetermined ratio, a method of preparing the same, and a hydrogel-formable composition including the same. For example, a hydrogel formed from the composition may be used for tissue regeneration or drug delivery or used as a storage, a body tissue regeneration inducer, or a filler in a body.