There is described inter alia a device having a surface comprising a layered coating wherein the outer coating layer comprises a plurality of cationic hyperbranched polymer molecules characterized by having (i) a core moiety of molecular weight 14-1,000 Da (ii) a total molecular weight of 1,500 to 1,000,000 Da (iii) a ratio of total molecular weight to core moiety molecular weight of at least 80:1 and (iv) functional end groups, whereby one or more of said functional end groups have an anti-coagulant entity covalently attached thereto.

According to various embodiments, a glove is provided with improved hydration characteristics and low dermatitis potential. The glove comprises a substrate and a polymer system that coats a surface of the substrate. The polymer system comprises: a polyol, a botanical extract, an emollient agent, a silicone copolymer dispersion, a lubricant, and a surfactant. The substrate may be free of sulphur and accelerators. An example formulation of the polymer system may comprise glycerol, Aloe vera, a carnauba wax dispersion, dimethicone, a polyalkylene glycol (PAG), and polyoxyethylene (20) sorbitan monooleate. The polymer system may be applied to the\surface of the substrate by dipping the surface into a water-based dispersion of the polymer system, or spraying the water-based dispersion onto the interior surface. The polymer system may be blended into water at a total solids content of 0.8% to 1.2% w/w to form the water-based dispersion.

Novel surgical sutures and novel medical devices made from novel semi-crystalline, glycolide-rich A-B-A triblock copolymers of glycolide and lactide, wherein said B-segment is a fully amorphous random copolymer of glycolide and lactide, for long term medical applications are disclosed. The novel polymer compositions are useful for long term absorbable surgical sutures, meshes and other medical devices, especially for patients with compromised healing. The novel sutures have improved properties and improved breaking strength retention, while still substantially absorbing within about a 120-day period post-implantation.

A medical needle may include a lumen coating configured to reduce surface energy of the lumen-facing/lumen defining surface, in a manner effective to slow and/or reduce coagulation of biomaterial (particularly blood) that contacts the needle lumen surface. Such a coating may include a hydrophobic coating such as a silane and/or siloxane material on at least the needle lumen surface. The coating reduces a surface energy of coated needle regions below the surface energy of uncoated regions, and particularly reduces the polar component of the surface energy in the coated needle regions. The needle may be a metallic biopsy needle with the coating comprised by at least a distalmost length of sample-collection lumen.

A method for implanting a medical device for implantation in a mammal joint. The method comprising the steps of creating an opening reaching from outside of the human body into the joint, providing said artificial contacting surface to said joint, fixating the artificial contacting surface to the joint, implanting said reservoir in the human body, and lubricating the artificial contacting surface with use of a lubricating fluid contained in said reservoir.

There is described inter alia a device having a surface comprising a layered coating wherein the outer coating layer comprises a plurality of cationic hyperbranched polymer molecules characterized by having (i) a core moiety of molecular weight 14-1,000 Da (ii) a total molecular weight of 1,500 to 1,000,000 Da (iii) a ratio of total molecular weight to core moiety molecular weight of at least 80:1 and (iv) functional end groups, whereby one or more of said functional end groups have an anti-coagulant entity covalently attached thereto.

Various embodiments disclosed relate to a lubricant. The lubricant includes a first non-amphiphilic triglyceride. The lubricant further includes a second non-amphiphilic triglyceride. The second non-amphiphilic triglyceride is different from the first non-amphiphilic triglyceride. The lubricant further includes a non-amphiphilic glycol ester.

This invention relates to comfortable ophthalmic devices and methods of producing such devices.

Described herein are compounds and compositions for the amelioration of arthritis or joint injuries by inducing mesenchymal stem cells into chondrocytes using intra-articular administration.

Lubricious coatings for medical devices and their uses are described.