A moldable medical membrane is provided, which includes a compact layer and a porous layer. The compact layer is formed from a first material. The porous layer is disposed on the compact layer, and the porous layer is formed from a second material. The moldable medical membrane has a moldable temperature range. A melting point of the compact layer is within the moldable temperature range, and a melting point of the porous layer is higher than the moldable temperature range.

The present invention relates to a formulation or composition for the treatment, repair, formation or regeneration of bone tissue in a subject, comprising Histatin-1 or its derivatives. The present invention also relates to a biomaterial comprising Histatin-1 or its derivatives in a biocompatible material, and a method for the treatment, repair, formation or regeneration of bone tissues in a subject comprising administering to the subject a therapeutically effective amount of Histatin-1 or its derivatives.

A device for treating orthopaedic trauma includes a device body having an exterior surface and a cannulation formed therein that extends from one longitudinal end of the device body to an opposite longitudinal end of the device body and at least one porous ingrowth material region associated with the exterior surface of the device body and fluidly coupled to the cannulation. The at least one porous ingrowth material region is configured to deliver a therapeutic agent from the cannulation to a region outside the device body.

A hyperbranched polymer includes a hyperbranched, hydrophobic molecular core, respective low molecular weight polyethyleneimine chains attached to at least three branches of the hyperbranched, hydrophobic molecular core, and respective polyethylene glycol chains attached to at least two other branches of the hyperbranched, hydrophobic molecular core. Examples of the hyperbranched polymer may be used to form hyperbranched polyplexes, and may be included in DNA or RNA delivery systems.

There is provided a method for preparing a dense hydrogel comprising an at least partially gelled hydrogel, placing the at least partially gelled hydrogel in fluid communication with an end of a capillary, and driving the at least partially gelled hydrogel into the capillary to form a dense hydrogel. There is also provided a system for preparing the dense hydrogel comprising a capillary having a bore; and a driver in communication with an end of the capillary for driving an at least partially gelled hydrogel into the bore of the capillary to form a dense hydrogel.

An artificial bone is provided comprising an inner core made from a porous material, the porous material comprising at least one fiber component having fibers, a liquid and a binder, and an outer layer comprising at least one fiber component having fibers, a liquid and a binder, wherein the ratio of the at least one fiber component having fibers to liquid to binder of the inner core is different from the ratio of the at least one fiber component having fibers to liquid to binder of the outer layer.

A bone repair composition and methods thereof include bone fibers made from cortical bone in which a plurality of bone fibers are made into various implant shapes conducive to introduction into a patient through minimally invasive surgery. The bone fiber compositions may be in the form of a pellet or cylinder. A method includes producing the bone fiber graft efficiently with control of key parameters of cohesiveness, rehydration and swelling of the bone fiber graft. Another method includes introducing the bone fiber graft into the cannula efficiently. A method is also provided to allow introduction of a bone graft into a patient by placing the implant in a tube and expelling it through the action of a plunger.

An antiseptic composition for use as bone cement, in particular an antiseptic polymethylmethacrylate bone cement. The composition can be cured and comprises a pharmacologically tolerable salt of a monoperoxy dicarboxylic acid, whereby the salt of the monoperoxy dicarboxylic acid can be dissolved from the composition in the presence of water. Preferably, the salt of the monoperoxy dicarboxylic acid in the composition is used in the form of a powder, whereby the powder has a mean particle size of not more than 250 μm. Preferably, the salt of the monoperoxy dicarboxylic acid, in solution at room temperature, is not degraded within 5 min by the catalase enzyme.

A bioactive composite includes 10% to 40% by weight of calcium sulfate (CaSO.sub.4), 10% to 20% by weight of tantalum pentoxide (Ta.sub.2O.sub.5), and 40% to 80% of polyetheretherketone (PEEK). Calcium sulfate is anhydrous calcium made by removing crystallization water of beta calcium sulfate hemihydrate.

Disclosed is directed to a method for restoring bone in an animal comprising: accessing a site to be restored; loading a syringe body with a flowable bone graft material; mating the syringe body with a delivery tube; positioning the delivery tube at the site to be restored; using a syringe piston to advance the said material into the delivery tube; using the syringe piston or a plunger that mates with the delivery tube after removal of the syringe body to deliver the bone graft to the site at a force of less than 50 lbs. extrusion force; wherein said material is at least 75% porous with a mineral to polymer ratio of 80:20.