The present disclosure relates to a method for treating a bone defect using a bio-material with increased porosity and reabsorption characteristics, the method comprising: (a) mixing a dry potassium phosphate based mixture with an aqueous solution to form a reabsorbable bio-material slurry, wherein the dry potassium phosphate based mixture comprises MgO, monobasic potassium phosphate, monobasic sodium phosphate, proteoglycans, and calcium sodium phosphosilicate, wherein a weight percent ratio of monobasic potassium phosphate to MgO is between about 3:1 and 1:1, wherein the dry potassium phosphate based mixture is configured to be mixed with the aqueous solution to thereby form a reabsorbable bio-material slurry, wherein the proteoglycans are between about 1-10 weight percent of the dry composition, (b) accessing a void of a bone defect within a bone, and (c) filling the void with the reabsorbable bio-material slurry, wherein the reabsorbable bio-material slurry is osteoconductive and osteoinductive, thereby enabling new bone growth in the void.

The present disclosure relates to a method for treating a bone defect using a bio-material with increased porosity and reabsorption characteristics, the method comprising: (a) mixing a dry potassium phosphate based mixture with an aqueous solution to form a reabsorbable bio-material slurry, wherein the dry potassium phosphate based mixture comprises MgO, monobasic potassium phosphate, monobasic sodium phosphate, proteoglycans, and calcium sodium phosphosilicate, wherein a weight percent ratio of monobasic potassium phosphate to MgO is between about 3:1 and 1:1, wherein the dry potassium phosphate based mixture is configured to be mixed with the aqueous solution to thereby form a reabsorbable bio-material slurry, wherein the proteoglycans are between about 1-10 weight percent of the dry composition, (b) accessing a void of a bone defect within a bone, and (c) filling the void with the reabsorbable bio-material slurry, wherein the reabsorbable bio-material slurry is osteoconductive and osteoinductive, thereby enabling new bone growth in the void.

A composition including, (a) a mineral particle, (b) endothelial cells and mesenchymal cells, and (3) hyaluronic acid, is provided. Moreover, a kit which includes: a syringe, a mineral particle covered with endothelial cells and mesenchymal cells organized in 2 or more cell layers attached to the mineral particle, and hyaluronic acid, is also provided. Last, a method for filling a gap in a bone of a subject in need thereof, including contacting the gap with a composition of: (a) a mineral particle, (b) endothelial cells and mesenchymal cells, and (3) hyaluronic acid is provided.

A composition including, (a) a mineral particle, (b) endothelial cells and mesenchymal cells, and (3) hyaluronic acid, is provided. Moreover, a kit which includes: a syringe, a mineral particle covered with endothelial cells and mesenchymal cells organized in 2 or more cell layers attached to the mineral particle, and hyaluronic acid, is also provided. Last, a method for filling a gap in a bone of a subject in need thereof, including contacting the gap with a composition of: (a) a mineral particle, (b) endothelial cells and mesenchymal cells, and (3) hyaluronic acid is provided.

The present invention relates to a method for producing whitlockite, and whitlockite produced thereby. A method for producing whitlockite according to one embodiment of the present invention comprises: a step of preparing a precursor solution by mixing a first solution containing a calcium (Ca) ion source material, a second solution containing a magnesium (Mg) ion source material, and a third solution containing a phosphate (PO4) source material; a heat-treatment step of heat-treating the precursor solution; and a step of separating and purifying the precipitate formed in the solution, after the heat-treatment step.

An object of the present invention is to provide a calcium phosphate powder that enables the preparation of a slurry for additive manufacturing with excellent dispersion stability, and enables the production of a three-dimensional additive manufacturing article with high strength, in additive manufacturing. Provided is a calcium phosphate powder, having an average particle size (D.sub.50) of 0.1 to 5.0 μm, and having a pore volume of mesopores (pore size: 2 to 50 nm) of 0.01 to 0.06 cc/g as measured by a gas adsorption method. The calcium phosphate powder has excellent dispersion stability in a slurry for additive manufacturing, and, by performing additive manufacturing using a slurry for additive manufacturing containing the calcium phosphate, it is possible to produce a three-dimensional additive manufacturing article with high strength, which is useful as an implant, such as an artificial bone.

An object of the present invention is to provide a calcium phosphate powder that enables the preparation of a slurry for additive manufacturing with excellent dispersion stability, and enables the production of a three-dimensional additive manufacturing article with high strength, in additive manufacturing. Provided is a calcium phosphate powder, having an average particle size (D.sub.50) of 0.1 to 5.0 μm, and having a pore volume of mesopores (pore size: 2 to 50 nm) of 0.01 to 0.06 cc/g as measured by a gas adsorption method. The calcium phosphate powder has excellent dispersion stability in a slurry for additive manufacturing, and, by performing additive manufacturing using a slurry for additive manufacturing containing the calcium phosphate, it is possible to produce a three-dimensional additive manufacturing article with high strength, which is useful as an implant, such as an artificial bone.

The present invention provides a method of promoting local bone growth by administering a therapeutic amount of a Sost antagonist to a mammalian patient in need thereof. Preferably, the Sost antagonist is an antibody or FAB fragment selectively recognizing any one of SEQ ID NOS: 1-23. The Sost antagonist may be coadministered together or sequentially with a matrix conducive to anchoring new bone growth. Orthopedic and Periodontal devices comprising an implantable portion adapted to be permanently implanted within a mammalian body and bearing an external coating ofa Sost antagonist are also disclosed, as it a method ofincreasing bone density by administering to a mammalian patient a therapeutic amount ofa Sost antagonist together with an antiresorptive drug.

Disclosed is a method for filling a root canal in a tooth. The method includes positioning a fiber in the root canal of the tooth, filling at least a portion of the root canal with an unset hydrogel composition, such that the unset hydrogel composition contacts at least a portion of the fiber, setting the hydrogel composition, thereby forming a set hydrogel, and removing the fiber from the set hydrogel, thereby leaving a channel in the set hydrogel. Methods and kits for repairing teeth are also described.

Disclosed is a method for filling a root canal in a tooth. The method includes positioning a fiber in the root canal of the tooth, filling at least a portion of the root canal with an unset hydrogel composition, such that the unset hydrogel composition contacts at least a portion of the fiber, setting the hydrogel composition, thereby forming a set hydrogel, and removing the fiber from the set hydrogel, thereby leaving a channel in the set hydrogel. Methods and kits for repairing teeth are also described.