Shoulder arthroplasty systems and configurations for components thereof are described. For example, implant systems for a total should arthroplasty (TSA), hemi shoulder arthroplasty, and reverse should arthroplasty (RSA) are described. In addition, exemplary configurations for baseplates, glenoid components, glenosphere components, humeral components, humeral head components, humerosocket components, connectors, and adaptors, are described.

Embodiments herein described provide antigen-presenting cell-mimetic scaffolds (APC-MS) and use of such scaffolds to manipulating T-cells. More specifically, the scaffolds are useful for promoting growth, division, differentiation, expansion, proliferation, activity, viability, exhaustion, anergy, quiescence, apoptosis, or death of T-cells in various settings, e.g., in vitro, ex vivo, or in vivo. Embodiments described herein further relate to pharmaceutical compositions, kits, and packages containing such scaffolds. Additional embodiments relate to methods for making the scaffolds, compositions, and kits/packages. Also described herein are methods for using the scaffolds, compositions, and/or kits in the diagnosis or therapy of diseases such as cancers, immunodeficiency disorders, and/or autoimmune disorders.

Embodiments herein described provide antigen-presenting cell-mimetic scaffolds (APC-MS) and use of such scaffolds to manipulating T-cells. More specifically, the scaffolds are useful for promoting growth, division, differentiation, expansion, proliferation, activity, viability, exhaustion, anergy, quiescence, apoptosis, or death of T-cells in various settings, e.g., in vitro, ex vivo, or in vivo. Embodiments described herein further relate to pharmaceutical compositions, kits, and packages containing such scaffolds. Additional embodiments relate to methods for making the scaffolds, compositions, and kits/packages. Also described herein are methods for using the scaffolds, compositions, and/or kits in the diagnosis or therapy of diseases such as cancers, immunodeficiency disorders, and/or autoimmune disorders.

Modular endoprosthesis for at least partial replacement of a tubular bone, comprising, as module components, a stem for insertion into a bone cavity of the tubular bone, and an end piece comprising a support body with a neck part arranged on the medial aspect thereof. Said module components being able to be coupled to each other and released from each other along a longitudinal axis of the shaft. The end piece has at least two different surface configurations on its support body, namely a closed surface (6′) on a medial aspect, and a porous configuration of the surface on the opposite, lateral aspect. The latter permits and positions the adhesion of muscle tissue, specifically without suturing. The muscle trauma caused by suturing, and the peak loads that occur at the respective suture points, can thus be avoided by virtue of the invention, by means of the location-specific direct adhesion of the muscle. It is thus possible to achieve quicker and reliable mobilization of the patient, and this with a reduced risk of complications.

Modular endoprosthesis for at least partial replacement of a tubular bone, comprising, as module components, a stem for insertion into a bone cavity of the tubular bone, and an end piece comprising a support body with a neck part arranged on the medial aspect thereof. Said module components being able to be coupled to each other and released from each other along a longitudinal axis of the shaft. The end piece has at least two different surface configurations on its support body, namely a closed surface (6′) on a medial aspect, and a porous configuration of the surface on the opposite, lateral aspect. The latter permits and positions the adhesion of muscle tissue, specifically without suturing. The muscle trauma caused by suturing, and the peak loads that occur at the respective suture points, can thus be avoided by virtue of the invention, by means of the location-specific direct adhesion of the muscle. It is thus possible to achieve quicker and reliable mobilization of the patient, and this with a reduced risk of complications.

According to the invention there is provided inter alia a medical device for delivering a paclitaxel to a tissue, the device the device having a coating layer applied to a surface of the device, the coating layer comprising components i), ii) and iii), wherein component i) is a therapeutic agent which is paclitaxel; and component ii) is urea or a pharmaceutically acceptable salt thereof, or a urea derivative or a pharmaceutically acceptable salt thereof; and component iii) is succinic acid, glutaric acid or caffeine, or a pharmaceutically acceptable salt of any one thereof.

According to the invention there is provided inter alia a medical device for delivering a paclitaxel to a tissue, the device the device having a coating layer applied to a surface of the device, the coating layer comprising components i), ii) and iii), wherein component i) is a therapeutic agent which is paclitaxel; and component ii) is urea or a pharmaceutically acceptable salt thereof, or a urea derivative or a pharmaceutically acceptable salt thereof; and component iii) is succinic acid, glutaric acid or caffeine, or a pharmaceutically acceptable salt of any one thereof.

The invention is to provide an ophthalmic lens comprising a lens body and an antimicrobial hydrophilic layer thereon and a manufacturing method thereof, wherein the antimicrobial hydrophilic layer comprises a polydopamine layer and a zwitterionic polymer non-covalently bonded on the polydopamine layer, and the zwitterionic polymer can be selected from one of the group consisting of phosphorylcholine polymer, sulfobetaine polymer, carboxybetaine polymer, mixed-charge polymer and a combination thereof.

The invention is to provide an ophthalmic lens comprising a lens body and an antimicrobial hydrophilic layer thereon and a manufacturing method thereof, wherein the antimicrobial hydrophilic layer comprises a polydopamine layer and a zwitterionic polymer non-covalently bonded on the polydopamine layer, and the zwitterionic polymer can be selected from one of the group consisting of phosphorylcholine polymer, sulfobetaine polymer, carboxybetaine polymer, mixed-charge polymer and a combination thereof.

A method of preparing a structure is provided. The method includes providing an initial structure; casting a first material in one or more void volumes of the initial structure; removing the initial structure from the first material; obtaining a cast structure comprising the first material; coating a second material on the cast structure; casting a third material using the coated cast structure; removing the first material; and obtaining a final structure. In various embodiments, the initial structure can include a first initial structure and a second initial structure and casting a first material in one or more first void volumes of the first initial structure and in one or more second void volumes of the second initial structure. In various embodiments, the method includes assembling the first cast structure and the second cast structure and obtaining an assembled structure comprising the first cast structure and the second cast structure.