The present invention relates to an in vitro method for creating a viable connective tissue and/or osseous tissue obtained by tribological solicitations of a biological culture. It further relates to a viable connective tissue and/or osseous tissue susceptible to be obtained by said method as well as to the use of said method or viable connective tissue and/or osseous tissue to prepare a biological implant.

Embodiments of the present disclosure encompass systems and methods for in-situ/in vivo, bottom-up tissue generation for wound repair, repair of tissue defects, and the like. Embodiments of the systems of the present disclosure include modular scaffolds seeded with cells (modular tissue forming units (MTFUs)) for packing a tissue defect, such that these MTFUs are able to fill the wound bed with cells of one or more needed tissue types supported by the modular scaffolding particles.

The present disclosure features adhesive compositions and methods of use thereof related to the medical, veterinary, and dental fields.

Methods and system for the repair of a ruptured anterior cruciate ligament using a femoral attachment are provided. Aspects of the invention include a scaffold attached by a suture to an fixation device. The fixation device and suture are secured to a femur and not to a tibia near or at the repair site.

This document provides methods and materials for treating fistulas (e.g., refractory fistulas such as refractory anal fistulas). For example, methods and materials for implanting a synthetic scaffold (e.g., fistula plug) comprising randomly arranged fibers comprising polymers of PGA and TMC and seeded with mesenchymal stem cells (e.g., adipose derived mesenchymal stem cells) located in the spaces between the randomly arranged fibers into a fistula (e.g., refractory anal fistula) of a mammal (e.g., a human) are provided.

Artificial meniscal scaffolds characterized by a composite of circumferential polymer fiber network and orthogonal polymer fiber network embedded in an arcuate bioresorbable matrix comprised of collagen and hyaluronic acid. The orthogonal polymer fiber network prevents separation of the circumferential polymer fiber networks. The polymer fiber networks convert axial compressive forces on the scaffolds to tensile loads on the circumferential polymer fibers. The composite scaffold can be anchored to bone by novel anchoring components that protect the polymer fibers and ensure immediate securement of the artificial meniscal scaffold to bone.

The present invention relates to porous composite materials and objects such as 3D scaffolds, in particular to bioactive and bioresorbable scaffolds that can be transformed at body temperature.

Materials and methods for preparing a hydrogel are disclosed. Specifically, two separate solutions A and B, of which the solution A comprises enzyme horseradish peroxidase and the solution B comprises hydrogen peroxide is provided. At least one of solution A or B comprises calcium ions in the form of a pharmaceutically acceptable salt, and further the solution A and/or the solution B comprises hydroxyphenyl derivative of hyaluronan of a particular formula. A hydrogel based on hydroxyphenyl derivative of hyaluronan and a method of preparing and using the same is also disclosed.

The present disclosure describes methods of treating a ligament injury with ligament grafting.

A system or method for bioprinting bone graft provides obtaining an image of the patient's oral facial area, and viewed with the image viewing software. A restoratively driven dental implant treatment plan is created to restore the patient's missing dentition. The restoratively driven treatment plan is created. A physical exam, review of a patient's desires and expectations, review of imaging, acquisition and review of patient photographs and intraoral digital impressions. The imaging and digital impressions are aligned, via software to create a virtual representation. The anticipated final implant retained dentures, unitary implant crowns, or implant bridges, are planned to provide optimal esthetic and functional results. Dental implants are then planned for prosthetic anchors. Bone deficiencies are evaluated and if areas of boney deficiency are present, a patient specific bone graft is designed to restore said deficient areas. Once designed, it may be printed via additive manufacturing.