A method for controlling generation of biologically desirable voids in a composition placed in proximity to bone or other tissue in a patient by selecting at least one water-soluble inorganic material having a desired particle size and solubility, and mixing the water-soluble inorganic material with at least one poorly-water-soluble or biodegradable matrix material. The matrix material, after it is mixed with the water-soluble inorganic material, is placed into the patient in proximity to tissue so that the water-soluble inorganic material dissolves at a predetermined rate to generate biologically desirable voids in the matrix material into which bone or other tissue can then grow.

Disclosed are composite materials comprising a porous, carbonated, calcium silicate ceramic having a microstructure comprising interconnected open pores; where the calcium silicate surface defining the pores is partially or completely coated with an amorphous silica layer, and the silica coating comprises an overlayer of calcium carbonate crystals; where the silica coating and calcium carbonate overlayer form a network that interconnects throughout the ceramic microstructure, but do not completely occlude the pores. Also disclosed are methods of forming such composite materials.

A biomaterial including a porous biocompatible structure having interconnected pores, wherein the pores have interior walls and are interconnected by passageways, the interior walls and passageways being coated with an osteoinductive aqueous demineralized bone extract solution, the aqueous demineralized bone extract solution including growth factors, proteins, a demineralized bone matrix and at least one of a weak acid and a guanidine hydrochloride, wherein the demineralized bone matrix is present per 100 g of the solution in an amount of from about 2 g to about 10 g.

An elastomer molded body for a medical device includes an elastomer portion and a filler. The elastomer portion contains a crosslinked fluorine-based elastomer. The filler is formed from a plurality of particles each of which has aspect ratio of 5 or more and specific surface area of 3 m.sup.2/g or more and 10 m.sup.2/g or less. The aspect ratio is defined as a ratio of a dimension in a long axis direction thereof to a dimension in a short axis direction thereof. The filler has an uneven distribution in a surface layer part of the elastomer portion and is oriented in a direction along a surface of the elastomer molded body.

An elastomer molded body for a medical device includes an elastomer portion and a filler. The elastomer portion contains a crosslinked fluorine-based elastomer. The filler is formed from a plurality of particles each of which has aspect ratio of 5 or more and specific surface area of 3 m.sup.2/g or more and 10 m.sup.2/g or less. The aspect ratio is defined as a ratio of a dimension in a long axis direction thereof to a dimension in a short axis direction thereof. The filler has an uneven distribution in a surface layer part of the elastomer portion and is oriented in a direction along a surface of the elastomer molded body.

The invention relates to a coating for an implant component, a method for producing an implant component having said coating, and a use of said coating on an implant component. The coating is intended for an implant component, in particular a spinal implant component, and is a TiNb coating which has, in addition to an atom % proportion of Ti and an atom % proportion of Nb, an atom % proportion of 5-30 atom % of Ag.

A health care and/or entertainment device protective film may be configured to contact human skin, e.g., to limit the transmission of infection by bacteria, fungi, protozoa, prions, and/or viruses. The film may be formed as a nanocomposite film including at least 75 wt. %, relative to total organic matrix weight, of polyethylene, silver particles, and TiO.sub.2 particles, wherein the silver particles and TiO.sub.2 particles are distributed within and/or on an outer surface of the polyethylene, wherein the silver particles have a size of 1 to 1,000 nm, and wherein the TiO.sub.2 particles have a size of 1 to 50 nm. Such films may be applied to health care and/or entertainment devices, including virtual reality googles.

The present disclosure relates to a composite material, in particular a composite material of metals, a process for producing a composite material, and a medical device, in particular an implant, based on the composite material. The composite material comprises at least 5 vol-% of Fe and at least 1 vol-% of Mg or Zn, wherein the composite material comprises a Mg or Zn phase and an Fe phase, wherein the average size of the Mg or Zn phase in at least one dimension is less than 20 μm, in particular less than 10 μm. The medical device, in particular an implant, may be suitable for fixing of bone fractures (as well as fractions of a tendon or a ligament, etc.) and/or corrections and may be capable of exhibiting a targeted failure representing a complete paradigm shift in the treatment of bone fractures and the like.

A biomedical device includes a zinc-based material including a matrix including zinc, and nanostructures dispersed in the matrix. Embodiments of this disclosure are directed to zinc (Zn)-based materials including dispersed nanostructures for biomedical applications and devices, such as bioresorbable vascular stents, bioresorbable ureteral stents, endoluminal springs for distraction enterogenesis, biodegradable bone implants with tunable modulus, guided bone generation membranes, bioresorbable dental membranes, and other biomedical implants, as well as other functional applications, such as biodegradable electronics and sensors.

A magnesium-based bulk metallic glass composite includes a magnesium-based bulk metallic glass composite comprising a magnesium-based material and a TiZr alloy.