A method of detecting the presence or absence of a sealant applied to a textile graft includes the steps of: providing a textile graft having a first surface and an opposed second surface; providing a water soluble masking agent; applying the water soluble masking agent to at least a portion of the first surface of the textile graft; providing a sealant solution; providing a visual indicator; applying the water insoluble sealing agent and the visual indicator to the second surface of the textile graft; and removing the water soluble masking agent after the step of applying sealing solution. The second surface has visual indication of the visual indicator and the first surface is substantially free of visual indication of the visual indicator. An implantable textile graft includes the selectively applied visual indicator.

A method of manufacturing a therapeutic material incorporating a soft thermoformable elastomer with a phase change material exhibiting high latent heat of fusion. The compound provides elasticity, softness, formability, and heat over an extended duration and to facilitate prolonged skin contact at elevated temperatures. Used in combination with active ingredients the increased temperature and formability provides enhanced transdermal delivery through the skin. Thermoplastic elastomers may be manufactured by mixing together plasticizing oil, a triblock copolymer, a paraffinic substance and one or more additives, e.g., an antioxidant, an antimicrobial agent, and/or other additives to form a mixture which melted then cooled into the thermoplastic elastomer. During cooling, the thermoplastic elastomer may be molded or otherwise formed into any number of articles including, but not limited to, prosthetic liners, prosthetic sleeves, external breast prostheses, breast enhancement bladders, masks, wound dressing sheets, wound dressing pads, socks, gloves, malleolus pads, metatarsal pads, shoe insoles, urinary catheters, vascular catheters, and balloons for medical catheters both vascular as well as urinary. Active ingredients are preferably added to the cooling thermoplastic elastomer when the temperature is below 100° F. to prevent heat degradation and/or breakdown of vital proteins.

Described herein is a three-dimensional platform delivery technology including a polymeric material.

Described herein is a three-dimensional platform delivery technology including a polymeric material.

The present invention is directed to compositions containing polymer matrix, fiber and/or additives which are suitable for load bearing applications for medical devices. The matrix can be formed from a group of polymers which resorb inside the body after implantation. These compositions contain reinforcing fibers that are incorporated into a resorbable polymer matrix to improve properties such as mechanical. The reinforcing fibers can be resorbable, non-resorbable, natural, or metallic. Additives can be incorporated into the matrix material or the fibers or both to provide a secondary effect. These additives can be bioceramics to provide an osteoconductive effect; antimicrobial particles such as silver; coloring agents, and radiopaque additives to make the implants visible under fluoroscopy. The additives may also contribute to improve mechanical properties. The Composite composition with Matrix, Fibers and/or additives can provide enhanced functionality of mechanical, Osteoconductive and tailored degradation characteristics that can result in superior properties conventionally not achievable for Bioresorbable composites.

The present invention is directed to compositions containing polymer matrix, fiber and/or additives which are suitable for load bearing applications for medical devices. The matrix can be formed from a group of polymers which resorb inside the body after implantation. These compositions contain reinforcing fibers that are incorporated into a resorbable polymer matrix to improve properties such as mechanical. The reinforcing fibers can be resorbable, non-resorbable, natural, or metallic. Additives can be incorporated into the matrix material or the fibers or both to provide a secondary effect. These additives can be bioceramics to provide an osteoconductive effect; antimicrobial particles such as silver; coloring agents, and radiopaque additives to make the implants visible under fluoroscopy. The additives may also contribute to improve mechanical properties. The Composite composition with Matrix, Fibers and/or additives can provide enhanced functionality of mechanical, Osteoconductive and tailored degradation characteristics that can result in superior properties conventionally not achievable for Bioresorbable composites.

Disclosed are Self-Gelling materials and structures or materials or structures having one or more self-gelling components that overcome existing gel limitations due to hydrogel localization for medical applications by providing, for example, 1) microstructurally, or physically, anchored characteristics to help localize the gel, and the overall printed, or otherwise formed structure, giving structural form to the gel that allows the gel to be localized within the body, and even sutured in place, and mitigates gel migration and extends its residence time; 2) to provide an underlying 3D printed structure to help contain and support the gel after implantation; and more. Self-Gelling 3D printed structures may be further processed via milling to yield deconstructed scaffold micro-granules, with the composition and nano-/micro- structure of the original larger structure. Deconstructed scaffold micro-granules may be hydrated to form a micro-granule embedded gel network that can be injected, giving form to injectable gels.

A system for performing a minimally invasive percutaneous procedure comprises a medical device comprising a hydrogel delivery needle (4) with a tip and a hydrogel outlet (6), an injectable, shear-thinning, self-healing viscoelastic hydrogel that exhibits a storage modulus (G′) of at least 600 Pa, and a tan δ (G"/G′) from 0.1 to 0.6 in dynamic viscoelasticity measured by a rheometer at 1 Hz and 1% strain rate at 25° C. The system may also comprise a coaxial cannula (2) having a lumen configured for receipt of the hydrogel delivery needle (4), wherein the hydrogel delivery needle comprises an adjustable positioning mechanism (8) configured to limit the advancement depth of the hydrogel delivery needle through the coaxial cannula to a predetermined depth distal to a distal-most end of the coaxial cannula.

A system for performing a minimally invasive percutaneous procedure comprises a medical device comprising a hydrogel delivery needle (4) with a tip and a hydrogel outlet (6), an injectable, shear-thinning, self-healing viscoelastic hydrogel that exhibits a storage modulus (G′) of at least 600 Pa, and a tan δ (G"/G′) from 0.1 to 0.6 in dynamic viscoelasticity measured by a rheometer at 1 Hz and 1% strain rate at 25° C. The system may also comprise a coaxial cannula (2) having a lumen configured for receipt of the hydrogel delivery needle (4), wherein the hydrogel delivery needle comprises an adjustable positioning mechanism (8) configured to limit the advancement depth of the hydrogel delivery needle through the coaxial cannula to a predetermined depth distal to a distal-most end of the coaxial cannula.

A longitudinal extending body with oriented fibers comprised of an organic compound, preferably cellulose fibers, with a hydrophilic and hydrophobic polymer having absorbable and non res sorbable qualities in the body, with an internal construction to promote cell growth. The longitudinal body has at least one wall having oriented fiber to include cellulose fiber extending the length of said body. This extending body has a surface that is smooth to the touch for additional processing methods such as machining, compression molding and 3 D printing.