A method for forming a material in an in situ medical device by initiating polymerization of water soluble polymer precursors in an aqueous solution during or after transport of the polymerizable solution from its storage container to a space inside the in situ medical device is described. The stored aqueous solution with water soluble precursors lacks a free radical initiator which, in a powder form, is introduced into the aqueous solution during or after its transport into the space inside the in situ medical device. This storage and delivery system provides greater stability to the stored aqueous solution, allowing it to be stored at ambient temperature and providing extended shelf life over the solutions used in existing in situ polymerization systems. The flexibility to store and deliver/transport only one aqueous solution, instead of requiring the use of two different solutions, is also a benefit.

The present invention relates to a medical Pt—W alloy, containing 10 mass % or more and 15 mass % or less of W, with the balance being Pt and inevitable impurities, in which a Zr content is 1000 ppm or less. Limiting the Zr content can improve workability, particularly workability at the stage of hot working. Regarding impurity control, further limiting a Ca content to 250 ppm or less can provide more suitable workability. The present invention is good in workability in processing into a wire included in an embolic coil, a guide wire or the like.

A polymeric material includes a polyisobutylene-polyurethane block copolymer. The polyisobutylene-polyurethane block copolymer includes soft segments, hard segments, and end groups. The soft segments include a polyisobutylene diol residue. The hard segments include a diisocyanate residue. The end groups are bonded by urea bonds to a portion of the diisocyanate residue. The end groups include a residue of a mono-functional amine.

An article or vessel is described including a vessel surface and a coating set comprising at least one tie coating, at least one barrier coating, and at least one pH protective coating. For example, the coating set can comprise a tie coating, a barrier coating, a pH protective coating and a second barrier coating; and in the presence of a fluid composition, the fluid contacting surface is the barrier coating or layer. The respective coatings can be applied by PECVD of a polysiloxane precursor. Such vessels can have a coated interior portion containing a fluid with a pH of 4 to 8. The barrier coating prevents oxygen from penetrating into the thermoplastic vessel, and the tie coating and pH protective coating together protect the barrier layer from the contents of the vessel. The second barrier coating is comparable to glass surface if needed.

A bioabsorbable wire material includes manganese (Mn) and iron (Fe). One or more additional constituent materials (X) are added to control corrosion in an in vivo environment and, in particular, to prevent and/or substantially reduce the potential for pitting corrosion. For example, the (X) element in the Fe—Mn—X system may include nitrogen (N), molybdenum (Mo) or chromium (Cr), or a combination of these. This promotes controlled degradation of the wire material, such that a high percentage loss of material the overall material mass and volume may occur without fracture of the wire material into multiple wire fragments. In some embodiments, the wire material may have retained cold work for enhanced strength, such as for medical applications. In some applications, the wire material may be a fine wire suitable for use in resorbable in vivo structures such as stents.

Medical devices, such as endoprostheses, and methods of making the devices are disclosed. The medical device can include a composite cover formed of a deposited metallic film. The cover may include one or more filaments, e.g., wires, which cooperate with the film to provide desirable mechanical properties. The wires may be integrated with the film by depositing the film over the wires.

PURPOSE: The present invention provides a polyvinyl chloride resin composition which is superior in heat stability and processability and has less elution from the composition. CONSTITUTION: a polyvinyl chloride resin composition comprising 100 parts by weight of a polyvinyl chloride resin, 10 to 120 parts by weight of di(2-ethylhexyl)terephthalate, and 0.5 to 20 parts by weight of epoxidized vegetable oil having a peroxide number of 5 or less.

A method for coating a medical implant applies at least one coating to at least one surface of the implant by plasma polymerization. The implant has pores sized in the nanometer range. The method stabilizes the pores. The plasma polymerization is conducted in the presence of a coating gas and oxygen. A coating parameter can be selected so that a rough surface of the implant is coated. An implant includes a membrane having pores sized in the nanometer range. A surface of the implant is at least partially coated with a plasma polymer. The interior of the pores is uncoated.

The present invention relates to methods for making wear and oxidation resistant polymeric materials by high temperature melting. The invention also provides methods of making medical implants containing cross-linked antioxidant-containing tough and ductile polymers and materials used therewith also are provided.

A hemostatic device is disclosed, which capable of favorably maintaining strength of an inflatable portion and reducing a pressing force acting on a site where bleeding is to be stopped over time to such an extent that vascular occlusion can be prevented without operation by a doctor or a nurse. The hemostatic device includes a band for wrapping around a wrist, a fastener or means for securing the band to the wrist in a wrapped state, and an inflatable portion connected to the band and inflated by being injected with a gas, in which the inflatable portion includes a resin layer made of a resin material, a particulate portion dispersed in the resin layer, and a space portion formed around the particulate portion. The space portion contains gas dispersed in the resin layer so as not to communicate between an inner surface and an outer surface of the resin layer.