The invention relates to a dialysis device that provides recirculating flow dialysis in a wearable and portable format. It uses an exchangeable purification unit holding a volume of dialysate and/or a sorbent system for the in-situ regeneration of dialysate. The invented dialysis device comprises a carrier that is mounted on a replaceable cartridge. The carrier holds the electronics, user-interface, actuators and sensors. It actuates, controls and monitors the dialysis operation. The cartridge is a replaceable part that is connected to the patient via a flexible tubing. It consists of a reusable housing with a memory chip and holds a disposable inlay containing the purification unit with fluid lines, connectors, dialysate and/or sorbents in combination with a nanofilter. The cartridge is intended for use during the day, as a wearable system. The cartridge can be enlarged with an extension set to offer more capacity. The extended cartridge is intended to be used during the night as a bedside device.

The invention relates to a system of performing an evidence Dialysis modality of Batch, Tidal or a combination of both. The system: isolates cavity volume changes due only to ultrafiltrate; determines the volume of a patient cavity; determines a full cavity; determines an objective time to initiate an exchange; and determines an empty cavity. One or more combination of these features provide for evidence base Fill, Dwell, and Drain sequences. The system comprises: a cassette having a heated region and a sensor region for measurements. A valve manifold supplies a patient connection with fluid. A microprocessor receives pressure measurements, controls the heated region and activates a volumetric pump to deliver or extract discrete increments of the fluid to the cassette from bags. Filtering pressure measurements to remove rapid fluctuations determines an accumulated pressure in the patient cavity. The volume of fluid in the patient cavity correlates to the accumulated pressure.

A fluid handling cassette, such as that useable with an automated peritoneal dialysis (APD) cycler device or other infusion apparatus, may include a generally planar body having at least one pump chamber formed as a depression in a first side of the body and a plurality of flowpaths for a fluid that includes a channel. A patient line port may be arranged for connection to a patient line and be in fluid communication with the at least one pump chamber via at least a first one of said flowpaths, and an optional membrane may be attached to the first side of the body over the at least one pump chamber. In one embodiment, the membrane may have a pump chamber portion with an unstressed shape that generally conforms to the depression of the at least one pump chamber in the body and is arranged to be movable for movement of the fluid in a useable space of the at least one pump chamber. One or more spacers may be provided in the at least one pump chamber to prevent the membrane from contacting an inner wall of the at least one pump chamber. The patient line, a drain line, and/or a heater bag line may be positioned to be separately occludable in relation to one or more solution lines that are connectable to the cassette.

A dialysis method to enable a patient to undergo both peritoneal dialysis and extracorporeal blood treatments is disclosed. The method includes determining, via a base unit controller, whether a peritoneal dialysis treatment or an extracorporeal blood treatment is to be performed. If the peritoneal dialysis treatment is to be performed, the method includes operating first software instructions that cause a base unit to use a first fluid stored in a fluid container. If the extracorporeal blood treatment is to be performed, the method includes operating second software instructions that cause the base unit to use a second, different fluid from an online source and selectively move the second, different fluid to a blood treatment unit for use in the extracorporeal blood treatment. The blood treatment unit is operable with the base unit to perform the extracorporeal blood treatment on a patient.

A renal therapy machine includes a blood filter including a plurality of porous fibers; a blood circuit in communication with the blood filter; and a dialysate circuit in communication with the blood filter and operable with at least one pump, wherein the renal therapy machine is configured to perform a priming sequence in which a physiologically compatible solution, other than dialysate, primes the blood circuit and is flowed within the fibers and through pores in the fibers of the blood filter, and the pump of the dialysate circuit vents air from the blood filter into the dialysate circuit.

An extracorporeal blood treatment apparatus comprises a blood treatment device (2), an extracorporeal blood circuit, a blood pump (8) configured to be coupled to a blood withdrawal line (6) of the extracorporeal blood circuit. A closed fluid line (10) is connected to an inlet port (4a) and to an outlet port (4b) of a fluid chamber (4) of the blood treatment device (2), wherein the closed fluid line (10) together with the fluid chamber (4) forms a recirculation loop. An evacuation line (15) departs from the closed fluid line (10). A warming device (13) and a recirculation pump (17) are coupled or configured to be coupled to the closed fluid line (10). At least one temperature sensor (22) is operative on the extracorporeal blood circuit and it is configured to sense a blood temperature (Tb). A control unit (25), connected to the warming device (13), to the recirculation pump (17) and to the temperature sensor (22), is configured to execute the following procedure: receiving from the temperature sensor (22) at least a signal correlated to the blood temperature (Tb); adjusting the blood temperature (Tb) by controlling at least one of the warming device (13) and the recirculation pump (17).

A method of controlling a medical fluid therapy machine display brightness includes: performing a medical fluid therapy using the medical fluid therapy machine, the medical fluid therapy machine including a display; sensing an amount of ambient light impinging the display without receiving light directly from the display; controlling a level of backlight brightness for the display based on the amount of ambient light sensed; and displaying information relating to the medical fluid therapy on the display using the controlled level of backlight brightness.

A peritoneal dialysis (PD) fluid line set includes a fluid line configured to carry spent dialysate to a drain receptacle and a chemical testing device disposed along the fluid line. The chemical testing device is configured to detect a presence of a substance in the spent dialysate as the spent dialysate flows past the chemical testing device, and the chemical testing device is configured to provide a visual indicator of the presence of the substance in the spent dialysate.

A peritoneal dialysis system is provided that includes a hardware unit, a disposable unit received by the hardware unit, and a controller. The hardware unit includes a recessed area, a piston having a contact surface, a pneumatic source for supplying a negative pressure, and an actuator configured to move the contact surface of the piston into and out of at least a portion of the recessed area. The disposable unit includes an outer member fitted at least partially within the recessed area of the hardware unit and a moveable membrane positioned between the contact surface of the piston and the outer member when the disposable unit is received by the hardware unit. The controller is configured to cause the pneumatic source to apply the negative pressure to the moveable membrane so as to conform the moveable membrane to a shape of the contact surface of the piston and follow the contact surface when the piston is moved towards and away from the outer member fitted at least partially within the recessed area.

Dialysis systems and methods for operating dialysis machines (e.g., peritoneal dialysis machines) for conducting dialysis treatments are disclosed. The dialysis system may include a dialysis machine for transferring dialysate to a patient from a dialysate source. The dialysate may flow from the dialysate source through a cassette (e.g., a disposable cassette) positionable within a port formed in the dialysis machine. The dialysis system may also include a cleaning cartridge insertable into the port. The cleaning cartridge may be arranged and configured to collect, remove, etc. any foreign material or debris from the port.