Extracorporeal blood flow circuit devices can be used during medical procedures such as on-pump open-heart surgery. For example, extracorporeal heat exchange and oxygenation devices can be used to facilitate surgical procedures such as coronary artery bypass grafting. In some embodiments, such an oxygenation device can include an integrated air removal structure. In particular embodiments, the air removal structure can comprise one or more porous hollow fibers.

A medical treatment system, such as a peritoneal dialysis system, may include a control system and other features to enhance patient comfort and ease of use. For example, the peritoneal dialysis system may include the control system that can adjust a volume of fluid infused into a peritoneal cavity to prevent an intraperitoneal fluid volume from exceeding a pre-determined amount. The control system can adjust by adding one or more therapy cycles, allowing for fill volumes during each cycle of the one or more therapy cycles to be reduced. The control system may continue to allow the fluid to drain from the peritoneal cavity as completely as possible before starting the next therapy cycle of the one or more therapy cycles. The control system may also adjust a dwell time of the fluid within the peritoneal cavity during the one or more therapy cycles in order to complete a therapy within a scheduled time period. A cycler may also be configured to have a heater control system that monitors both a temperature of a heating tray and a temperature of a bag of dialysis fluid in order to bring a temperature of the dialysis fluid rapidly to a specified temperature, with minimal temperature overshoot.

A blood purification apparatus that is capable of, with no preparatory operations, performing substitution by supplying dialysate in a dialysate introduction line to a blood circuit during ultrafiltration treatment, or performing blood return by immediately supplying the dialysate in the dialysate introduction line to the blood circuit after the ultrafiltration treatment. A blood purification apparatus includes a dialyzer, a dialysate introduction line, a dialysate drain line L2 through which drain liquid from the dialyzer is drained, and an ultrafiltration pump capable of removing water from the blood in the blood circuit. The blood purification apparatus is capable of performing substitution or blood return by supplying the dialysate in the dialysate introduction line L1 to the blood circuit. In an ultrafiltration treatment in which the ultrafiltration pump is activated while the introduction of the dialysate into the dialyzer is stopped, dialysate delivery is performed while the introduction of the dialysate into the dialyzer is prevented.

A heat exchanger for a blood circulation circuit comprises a hollow fiber membrane layer having a plurality of hollow fiber membranes, and a fixing portion fixing both end portions of the hollow fiber membranes from outsides of the hollow fiber membranes. The fixing portion mainly contains polyurethane, and each of the hollow fiber membranes has a heat conductive layer containing high density polyethylene, and an adhesion layer provided on an outside of the heat conductive layer, bonded to the fixing portion, and mainly containing a modified polyolefin resin.

A leak may be detected in a heat exchanger of a hemodialysis device. A drain valve is opened by the controller, and then closed by the controller after a pre-selected time period. An initial pressure is determined in the spent dialysate circuit and stored in the memory. A system pressure is determined at periodic time intervals and compared to a pre-determined maximum pressure. The controller then determines whether the heat exchanger has a leak, in that in response to the system pressure exceeding a predetermined maximum pressure, a command is generated to execute an event including suspending a disinfectant operation with a disinfecting agent, and in response to the initial pressure subtracted from the system pressure being greater than a predetermined minimum pressure differential, a command is generated to execute an event including suspending the cleanse operation with the disinfecting agent.

The present disclosure discloses an integrated membrane oxygenator including an oxygenator and a filter attached to the oxygenator. The oxygenator may include an upper cover, a lower cover, a shell, and an oxygenation structure. Two ends of the filter may be respectively connected with the upper cover and the lower cover. The oxygenation structure may include a mandrel, an oxygen pressure membrane, and a temperature-changing membrane arranged inside the shell. The filter may include a filter shell, a diversion structure, and a filter screen arranged inside the filter shell. An inlet of the filter shell may be connected with a blood outlet on the lower cover of the oxygenator, and blood oxygenated by the oxygenator may directly enter the filter for filtration.

The embodiments of the present disclosure may provide a membrane oxygenator with a built-in filter, including an upper cover, a lower cover, a shell and an oxygenation structure, wherein two ends of the shell may be respectively connected to the upper cover and the lower cover, and the oxygenation structure may be disposed in the shell, including a mandrel, a filter screen, an oxygen pressure membrane, and a temperature-changing membrane in turn from a center to an outside. The blood may flow in from an upper blood inlet of the membrane oxygenator, traverse the temperature-changing membrane, oxygen pressure membrane and filter screen in turn, and then flow out from a blood outlet under the mandrel. During a process of traversing, a flow rate of the blood may gradually slow down, and the blood may fully contact the oxygen pressure membrane and the filter screen.

A heat exchanger for a blood circulation circuit includes a hollow fiber membrane layer having a plurality of laminated hollow fiber membranes 31. Each of the hollow fiber membranes 31 has a barrier layer 5 having a hydrogen peroxide barrier property, and the barrier layer 5 has an oxygen permeability coefficient of 6 cc.Math.cm/m.sup.2.Math.24 h/atm or less at 25° C.

A fluid handling cassette, such as that useable with an automated peritoneal dialysis (APD) cycler device or other infusion apparatus, may include a generally planar body having at least one pump chamber formed as a depression in a first side of the body and a plurality of flowpaths for a fluid that includes a channel. A patient line port may be arranged for connection to a patient line and be in fluid communication with the at least one pump chamber via at least a first one of said flowpaths, and an optional membrane may be attached to the first side of the body over the at least one pump chamber. In one embodiment, the membrane may have a pump chamber portion with an unstressed shape that generally conforms to the depression of the at least one pump chamber in the body and is arranged to be movable for movement of the fluid in a useable space of the at least one pump chamber. One or more spacers may be provided in the at least one pump chamber to prevent the membrane from contacting an inner wall of the at least one pump chamber. The patient line, a drain line, and/or a heater bag line may be positioned to be separately occludable in relation to one or more solution lines that are connectable to the cassette.

A dialysis fluid system includes a dialysis fluid inlet; a dialysis fluid outlet; a pump positioned and arranged to pump dialysis fluid through the dialysis fluid inlet and the dialysis fluid outlet; and an inductive heater located between the dialysis fluid inlet and the dialysis fluid outlet, the inductive heater including a fluid flowpath positioned and arranged to receive non-heated dialysis fluid from the dialysis fluid inlet and to output heated dialysis fluid to the a dialysis fluid outlet, a conductive heater element located within the fluid flowpath so as to be or act as a secondary coil of a transformer, and a primary coil of the transformer located outside of the fluid flowpath and positioned so as to magnetically induce a current into the conductive heater element, causing the conductive heater element and surrounding fluid to heat.