The disclosed device, systems and methods relate to a novel catheter, system and methods. Exemplary embodiments comprise a plurality of lumens and balloons for insertion into the aorta and vena cava.

The present invention relates to a portable lung assist device. In one embodiment, the portable lung assist device comprises an integrated oxygenator, blood pump, and cannula. In one embodiment, the portable lung assist device of the present invention does not require an oxygen tank, but instead can provide oxygen to a subject's blood from ambient air. In one embodiment, at least a portion of the portable lung assist device, for example the cannula can be implantable. In one embodiment, the cannula of the device of the present invention can be inserted in to the subject's pulmonary artery. A method for providing portable lung assistance is also described.

A system and methods are described for improving the management of ischemic cardiac tissue during acute coronary syndromes. The system combines a catheter-based sub-system which allows for simultaneous balloon dilation of a coronary artery and infusion of a carefully controlled perfusate during percutaneous coronary intervention. The system allows for modulation of levels of oxygen at the time of percutaneous intervention. In addition, catheters and systems are provided for administration of fluids with modified oxygen content during an intervention that incorporate upstream flow control members to compartmentalize the perfusion of the target coronary artery and the remainder of the heart.

Extracorporeal blood flow circuit devices can be used during medical procedures such as on-pump open-heart surgery. For example, extracorporeal heat exchange and oxygenation devices can be used to facilitate surgical procedures such as coronary artery bypass grafting. In some embodiments, such an oxygenation device can include an integrated air removal structure. In particular embodiments, the air removal structure can comprise one or more porous hollow fibers.

Extracorporeal membrane oxygenation systems and methods of use are disclosed. Several publications and patent documents are cited throughout the specification in order to describe the state of the art to which this invention pertains. Full citations of these references can be found throughout the specification. Each of these citations is incorporated herein by reference as though set forth in full.

A blood processing apparatus includes an optional heat exchanger and a gas exchanger disposed within a housing. In some instances, the gas exchanger can include a screen filter spirally wound into the gas exchanger such that blood passing through the gas exchanger passes through the screen filter and is filtered by the spirally wound screen filter a plurality of times.

A system configured to enclose a premature fetus within an extracorporeal environment to promote growth of the fetus and increase viability of the fetus. The system includes a chamber having an interior space configured to enclose the fetus, a first fluid circuit that delivers sterile fluid to the chamber, and a second fluid system that transfers oxygen to the fetus. The system chamber includes a stop mechanism including a clamp and an actuator, the clamp positioned in the interior space, the actuator coupled to the clamp such that movement of the actuator moves the clamp, and the actuator positioned at least partially outside the interior space.

A blood pump for causing blood to flow in one direction is used for a blood oxidation system that circulates blood in a body to an oxidizer so as to supply oxygen into the body from outside the body. The blood pump includes an outer wall having a gas outlet port formed through a lateral surface thereof; a blood chamber having a pouch which is inserted into the outer wall and of which opposite ends are connected to opposite ends of the outer wall, respectively; a pump injection valve fluid-communicably coupled to one end of the blood chamber and blocking blood from flowing to the blood chamber; and a pump discharge valve fluid-communicably coupled to the other end of the blood chamber and blocking blood from flowing from the blood chamber.

A dual lumen drainage cannula configured for use in a veno-arterial extracorporeal membrane oxygenation (VA ECMO) system includes a first drainage tube having a proximal end, a distal end, and at least one aperture defined proximate its distal end and in fluid communication with the lumen of the first drainage tube, and a second drainage tube having a proximal end, a distal end, and at least one aperture defined proximate its distal end and in fluid communication with the lumen of the second drainage tube. The dual lumen drainage cannula further includes a flow restrictor disposed within the lumen of at least one of the first and second drainage tubes, configured to adjust the flow distribution of blood flow through the lumens of the first and second drainage tubes.

An oxygenator having a plurality of porous hollow fiber membranes for gas exchange to treat blood is manufactured by dissolving a silicone compound in an organic solvent having a surface tension of less than 70 dyn/cm to prepare a coating solution, and bringing an inner surface of the hollow fiber membranes into contact with the coating solution under a negative pressure of 50 hPa or more and 150 hPa or less to form a silicone compound-containing coating layer on the inner surface. An antithrombotic polymer compound-containing coat can be provided directly on an outer surface of the hollow fiber membranes.