A disposable cell enrichment kit includes a crossflow filtration device configured to be disposed along a main loop pathway and to receive a process volume containing a biological sample and utilize crossflow filtration, via a micro-porous membrane, to retain a specific cell population in a retentate from the process volume and to remove a permeate including certain biological components from the process volume. The crossflow filtration device includes a laminated filtration unit that includes the micro-porous membrane, a first mating portion, a second mating portion, and a membrane support. The membrane support includes a first plurality of structural features that define a first plurality of openings, wherein the first plurality of structural features are coupled to the micro-porous membrane and provide support to the micro-porous membrane, and the first plurality of openings allow the permeate to flow through them after crossing the micro-porous membrane.

A blood component collection cassette that can trap a substance where blood components coagulate by using a simple and economical configuration, and a manufacturing method of the blood component collection cassette are provided. A blood component collection cassette (28) includes a cassette main body (40) where a flow path (42) is formed and is configured to be mountable to a centrifugal separation device (14). The cassette main body (40) has a first sheet (40a) and a second sheet (40b) which are formed of a soft material. The flow path (42) is formed between the first sheet (40a) and the second sheet (40b). A filter member (60) for trapping a substance where blood components coagulate is arranged on the flow path (42) in the cassette main body (40).

A centrifugal separation device of a blood component collection system, which is one form of a biological component collection system, performs a pressure release step of stopping a collection and returning pump at the end of a returning operation, and releasing a positive pressure inside a filter structural member, a clamp closure step of closing an inlet flow passage and an outlet flow passage of the filter structural member, and a collection operation starting step of starting a subsequent collection operation.

The invention relates generally to methods of improving function of a transplanted organ, treating or preventing primary graft dysfunction of a transplanted organ, treating or preventing acute rejection of a transplanted organ, treating or preventing delayed graft function, or achieving a clinical endpoint indicative of a successful organ transplant in a recipient of the transplanted organ which comprise contacting blood from the recipient with an extracorporeal membrane having a plurality of pores having an average pore size of at least 40 kDa, 50 kDa or 60 kDa to permit inflammatory cytokines and other inflammatory molecules to pass through the pores and out of the blood that is returned back to the recipient.

Provided is a blood component sampling cassette which can be efficiently manufactured at low cost compared to a conventional cassette, a method for manufacturing the blood component sampling cassette, a blood sampling circuit set and a blood component sampling system. The blood component sampling cassette includes a cassette main body having a plurality of flow paths including an introduction line, a blood component transfer line and a retransfusion line. The cassette main body includes a first sheet and a second sheet which are formed of a soft material compatible with autoclave sterilization. The first sheet and the second sheet are overlaid in a thickness direction and bonded to each other. A plurality of flow paths is formed between the first sheet and the second sheet.

A dialysis machine that includes a valve member having a deformable area configured to deform outwardly away when pressurized fluid is introduced into the valve member. The valve member is configured so that, when a dialysis fluid cassette is disposed in a cassette compartment of the dialysis machine and pressurized fluid is introduced into the valve member, the deformable area obstructs a fluid channel of the dialysis fluid cassette to control dialysis fluid flow therethrough.

An extracorporeal circuit has been conceived including: lines (16) which include passages for blood or a medical liquid; a connector (38, 40) at a free end of each of the lines (16); a cassette (18) supporting the lines, and dummy connectors (42, 44) attached to the cassette (18) and each adapted to form a mating connection with a respective one of the connectors (38, 40) at the free ends of the lines (16), wherein the connectors (38, 40) are arranged in accordance with a sequence in which the lines (16) are attached for a blood treatment session or are grouped in accordance with types of liquids to flow through the lines (16) during the blood treatment session. The extracorporeal circuit may be a circuit for dialysis and the circuit includes a hemodialyzer. Further, the connectors (38, 40) and dummy connectors (42, 44) may each be one of a male or female luer lock connector, and the dummy connectors (42, 44) may include both male and female connectors.

A machine is provided with a slot to releasably receive and retain a cartridge in which dialysis is effected. The machine is configured for supplying to the cartridge, at a controlled temperature and rate, sterile water for use in haemodialysis and is operable to maintain, in a sterile condition, residual water contained therein after completion of a haemodialysis treatment.

The invention relates to a blood treatment device comprising an attachment unit 7 for attaching a functional unit 1 intended for single use for carrying out the blood treatment. The blood treatment device according to the invention is characterised by a monitoring unit 8 for monitoring the operability and/or the operating state of the functional unit 1, which functional unit comprises at least one light transmitter 17A, 18A and at least one light receiver 17B, 18B. The light transmitter and light receiver are arranged in the monitoring unit 8 according to the invention on one side of the functional unit 1. The arrangement of the light transmitter and light receiver on the same side has the advantage that the monitoring unit 8 can be integrated into the attachment unit 7 of the blood treatment device without any major structural modifications. The monitoring of the functional unit 1 is based on an optical measurement method in which the light reflected on a part of the functional unit 1 or a part of the attachment unit 7 is detected. A calculation- and evaluation unit 13 is configured such that conclusions can be drawn as to a defective state and/or a certain operating state of the functional unit 1 based on the intensity of the light falling on the functional unit and the light reflected on the functional unit or the attachment unit.

An external functional means comprises at least one housing body, at least one chamber integrated into the housing body for receiving medical fluids, at least one passage integrated into the housing body for receiving and/or conducting a medical fluid, and at least one valve means completely or partly integrated into the housing body for controlling or regulating a fluid flowing through the external functional means. The invention further specifies a blood treatment apparatus and methods which may be carried out by means of the external functional means of the invention and by means of the blood treatment apparatus, respectively.