The present invention relates to a method for preparing a macromolecular composition comprising phenylglyoxaldehyde-derivatives. The invention also relates to the macromolecular compositions per se, and to methods of using the macromolecular compositions. The macromolecular compositions are useful for undergoing subsequent reactions with small molecules, for instance to remove such small molecules from a solution.

The present disclosure relates to devices, e.g, extracorporeal blood purification (EBP) devices, which comprise a cartridge or sorbent comprising a cellular membrane derived from a cell. The present disclosure also relates methods for removing or reducing a substance, e.g, an undesirable substance, from a fluid, e.g, a subject’s blood, using the devices or EBP devices.

A process for removing Sr.sup.2+ toxins from bodily fluids is disclosed. The process involves contacting the bodily fluid with an ion exchanger to remove the metal toxins in the bodily fluid, including blood and gastrointestinal fluid. Alternatively, blood can be contacted with a dialysis solution which is then contacted with the ion exchanger. The ion exchangers are represented by the following empirical formula:
A.sub.mZr.sub.aTi.sub.bSn.sub.cM.sub.dSi.sub.xO.sub.y. A composition comprising the above ion exchange compositions in combination with bodily fluids or dialysis solution is also disclosed. The ion exchange compositions may be supported by porous networks of biocompatible polymers such as carbohydrates or proteins.

The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

The invention relates to a blood treatment device for carrying out an extracorporeal blood treatment in which blood is guided in a blood guidance device having a main blood line and at least one secondary line, the latter being fluidically connected to the main blood line and the main blood line having a dialyzer and, downstream from the dialyzer, a blood treatment element, wherein the blood treatment device has a control device; and a pump configuration, which is equipped for generating blood flows in the main blood line and also in the at least one secondary line, wherein the control device is designed to operate the pump configuration in such a way that a first blood flow rate in the dialyzer is decoupled from a second blood flow rate in the blood treatment element. Furthermore, the invention relates to a blood guidance device for cooperation with the blood treatment device as well as for a blood treatment system.

The invention relates to the treatment of an individual suffering from a cytokine storm syndrome. It relates to methods for the treatment of such an individual and to systems and devices for use in such treatment.

A blood filter device having an iron-chelating molecule, a haem-binding molecule and a haemoglobin-binding molecule bound to a support. Use of the device in a vessel containing blood, for example a blood bag or a flow line, removes haemolysis-derived components from the blood.

The present disclosure relates to a dialysis apparatus comprising a membrane having at least one protein from the lipocalin family bound thereon. The disclosure further relates to methods of removing non-polar, hydrophobic and/or protein bound uremic toxins from a target subject utilizing the dialysis apparatus described herein as well as methods of extracorporeal detoxification.

An object of the present invention is to provide a purification column which is a small purification column in which a volume of a liquid to be treated is reduced in order to reduce the amount of blood to be taken out and which realizes a low pressure loss and has high adsorption performance. The present invention provides a fiber bundle including a plurality of porous fibers that satisfies the following requirements (A) to (E):

(A) the porous fiber has a non-hollow shape,

(B) an arithmetic average roughness (dry Ra value) of a surface of the porous fiber in a dry state is 11 nm or more and 30 nm or less,

(C) an arithmetic average roughness (wet Ra value) of a surface of the porous fiber in a wet state is 12 nm or more and 40 nm or less,

(D) a value represented by wet Ra/dry Ra is 1.05 or more, and

(E) a linear rate of the fiber bundle represented by (length of fiber bundle)/(length of one porous fiber) is 0.97 or more and 1.00 or less.

An embodiment provides a method for treating a body fluid of a patient, including: removing the body fluid from a patient; applying a treatment to the body fluid, wherein the treatment comprises an antibody that joins with an aging process targeted antigen (TA) in the body fluid to form an antibody-TA complex, wherein the antibody comprises a tag sensitive to an illumination; removing the antibody-antigen complex from the body fluid; and returning the body fluid to the patient. Other aspects are described and claimed.