Provided are systems and methods for treating a biological fluid, e.g., to inactivate pathogens.

Provided are systems and methods for treating a biological fluid, e.g., to inactivate pathogens.

An extracorporeal photopheresis system includes a separator with a disposable fluid circuit including a treatment container, an irradiation device configured to treat the contents of the treatment container, and a controller configured to control the system to perform a procedure including drawing anticoagulated whole blood into the fluid circuit from a blood source and returning to the blood source a treated target cell component, a portion of a red blood cell component remaining in the fluid circuit, and/or a portion of a plasma component remaining in the fluid circuit. The controller is further configured to estimate an end-of-procedure fluid balance estimated based on manual or automatic inputs including a patient body weight associated with the blood source and a total blood volume of the blood source, indicate the fluid balance to an operator, and receive one or more changes that affect the fluid balance after indicating the fluid balance.

Systems and method for verifying the timely placement of a container of biolocal cells or fluid within a treatment chamber of a biological fluid treating device are disclosed. The systems and methods utilize a sensor that detects the presence of a container at an appropriate and pre-determined time and, optionally, detects the weight of the container and cells.

Methods and compositions for the prevention or reduction of platelet transfusion associated complications are provided. The subject methods include modifying donor whole blood or platelets prior to transfusion to prevent or reduce alloimmune platelet refractoriness.

An apparatus and method for the batch photoactivation of mononuclear cells (MNCs) is described. The system includes a programmable controller configured to automatically separate whole blood in a first collection cycle to obtain a first quantity of MNCs; separate whole blood in a second collection cycle to obtain a second quantity of MNCs while simultaneously photoactivating the first quantity of MNCs to obtain a first quantity of treated MNCs; either store the first quantity of treated MNCs or reinfuse the first quantity of treated MNCs; photoactivate the second quantity of MNCs to obtain a second quantity of treated MNCs; either store the second quantity of treated MNCs or reinfuse the second quantity of treated MNCs; and reinfuse any blood components remaining after the second collection cycle.

Systems and methods are disclosed for performing online extracorporeal photopheresis in which the needs of a particular patient as to the fluid balance to be achieved and the time allotted to perform the procedure can be prioritized. Whole blood is removed from a patient and introduced through a processing set into a separation chamber to separate the desired cell population from the blood. The separated cell population is processed through the set which is associated with a treatment chamber where the cells are treated. Once treated, the cells are returned to the patient.

A machine comprising a load-bearing body intended to receive a circuit for the extracorporeal circulation of a biological liquid, where the circuit comprises at least one bag containing the biological liquid, at least one collection container of the biological liquid to be treated, at least one transit duct of the biological liquid connected to at least the bag and to the collection container; a pumping unit/device/component/etc. of the biological liquid crossing the transit duct; an irradiation unit/device/component/etc. by way of UVA rays of the collection container; and at least one containment box defining a containment volume intended to house the collection container and at least one safety chamber arranged below the containment volume and communicating therewith, to collect any possible spillage of the biological liquid from the collection container where the safety chamber has at least one bottom wall and two side walls at which it is hermetically sealed.

An embodiment provides a method for treating a body fluid of a patient with morbid obesity, including: removing the body fluid from a patient; applying a treatment to the body fluid, wherein the treatment comprises an antibody that joins with a morbid obesity targeted antigen (TA) in the body fluid to form an antibody-TA complex, wherein the antibody comprises a tag sensitive to an illumination; removing the antibody-TA complex from the body fluid using an illumination source; and returning the body fluid to the patient. Other aspects are described and claimed.

The present disclosure relates to a method of treating conditions and/or diseases using blood irradiation. Conditions and diseases include cytokine storm syndrome, autoimmune diseases, and infectious diseases. The disclosure also relates to modulation of the immune system, for example by modulating leukocytes. The method involves removal of blood, exposing the removed blood to radiation, and placing the exposed blood into a patient. Radiation includes ultraviolet radiation and other types of radiation.