This disclosure includes negative pressure wound therapy dressings with local oxygen generation for topical wound therapy. The dressings (18) for facilitating delivery of oxygen and application of negative pressure to target tissue include a manifold (46) that defines a plurality of gas passageways (50) and is configured to allow communication of oxygen to the target tissue; an oxygen-generating material (146) that is configured to release oxygen when exposed to water; a gas-occlusive layer (74) configured to be disposed over the manifold and the oxygen-generating material and coupled to tissue surrounding the target tissue such that an interior volume containing the manifold and the oxygen-generating material is defined between the gas-occlusive layer and the target tissue; and a port (94) coupled to the gas-occlusive layer and configured to be coupled to a negative pressure source.

A system and apparatus for the collection of serous or serosanguinous fluid from a percutaneous site after surgery. A pump unit with one or more pumps or powered sources provide continuous negative pressure suction to draw fluid from the percutaneous site and pumps the fluid into disposable reservoirs with one-way valves that are easy to handle while maintaining sterility and a seal to prevent the loss of vacuum. Air is continuously removed from the reservoirs. Measurement and analysis of the output is performed automatically. Additionally, through such a peristaltic pump device, controlled collection of measured surgical and/or bodily fluid from a subject patient may be undertaken allowing for more effective and closer analysis, as well.

Embodiments of the present disclosure encompass systems and methods for in-situ/in vivo, bottom-up tissue generation for wound repair, repair of tissue defects, and the like. Embodiments of the systems of the present disclosure include modular scaffolds seeded with cells (modular tissue forming units (MTFUs)) for packing a tissue defect, such that these MTFUs are able to fill the wound bed with cells of one or more needed tissue types supported by the modular scaffolding particles.

A dressing for treating tissue with negative pressure is provided herein comprising a composite of dressing layers, including a release film, a perforated coated polymer film, a manifold, and an adhesive cover. Additionally, a method of manufacturing the dressing may comprise applying a cross-linkable polymer to a polymer film, curing the cross-linkable polymer to a gel layer to form a coated polymer film, and perforating the coated polymer film to form fluid restrictions, such as slits and/or slots, though the coated polymer film.

A negative pressure wound therapy device can include a negative pressure source configured to be connected, via a fluid flow path, to a wound, a valve positioned in the fluid flow path and configured to, in an open state, permit supply of negative pressure from the negative pressure source upstream of the valve and, in a closed state, block supply of negative pressure from the negative pressure source upstream of the valve, a flow restrictor positioned in the fluid flow path, and a pressure sensor configured to measure a pressure differential across the flow restrictor. The device can include control circuitry configured to, in a normal operational mode, cause the valve to be in the open state and, in a test mode, perform at least one of a leak test, a flow test, or an excessive pressure test.

An appliance is provided for negative-pressure therapy of wounds on the human or animal body in which, on the one hand, a substance is delivered to a wound bed (W) and, on the other hand, fluids, in particular an exudate and the delivered substance, are aspirated from the wound bed by negative pressure. The appliance has a suction pump housing, with a suction pump arranged therein for aspirating the fluids from the wound bed (W), and a fluid collection container for collecting the aspirated fluids. Moreover, the appliance has a first measuring device and a second measuring device. The first measuring device serves to determine the quantity of the aspirated fluids, and the second measuring device serves to determine the quantity of the substance delivered to the body.

The present disclosure, when used by a live actor, may allow users to safely simulate hemorrhaging in some of the most challenging blood vessels in the most challenging anatomical locations such as the carotid artery, the axillary artery, and the femoral artery. The present disclosure may further provide the ability for users to safely perform hemorrhage control procedures, such as compression and ligation. The simulated wound of the present disclosure may be compressed to control hemorrhage. The simulated wound receptacle of the present disclosure may be packed with hemostatic or simple gauze to control hemorrhage. The simulated blood vessel of the device may be ligated with hemostats or other ligating instruments or material and bandaged with pressure dressings to control hemorrhage.

A negative pressure wound closure system and methods for using such a system are described. Preferred embodiments of the invention facilitate closure of the wound by utilizing a stabilizing structure that preferentially contracts to provide for movement of the tissue. Some embodiments may utilize a protective layer, such as a mesh or net layer, attached to a top surface of the stabilizing structure. The protective layer prevents a drape positioned over the stabilizing structure from being drawn into cells of the stabilizing structure, and permits visualization of the collapse of the cells.

A curable composition for use in wound care comprising, apportioned between at least one Part A and at least one Part B: one or more alkenyl-group containing polymers (i) having at least one alkenyl group or moiety per molecule, one or more SiH-containing polymers (ii) having at least one Si—H unit per molecule; and a catalyst (iii) for curing by addition of alkenyl-containing polymer (i) to SiH-containing polymer (ii), Part A and Part B independently having viscosity at 23° C. in the range 5-300 Pa.Math.s, preferably 10-100 Pa.Math.s, at a shearing rate of 10 s.sup.−1, and when combined in one Part having cure time at 23° C. in the range from 0.5 min to 25 min, wherein when dispensed into a location about a wound dressing, said wound dressing overlying a wound site and skin thereabout, said dispensing being so as to intimately contact and overlie an edge of said dressing and skin about said edge, the composition cures in contact with said edge and skin at 32° C. to an elastomer exhibiting zero or low tack at a time in the range from 0.5 to less than 30 minutes, apparatus for use with said composition comprising dispensing apparatus or wound dressing, a kit comprising the same, and methods of dispensing and curing the same and of using the same in sealing a wound dressing and in treating a wound site of a human in need thereof.

A volume of a wound is estimated using a dynamic pressure response measured during instillation of fluid to the wound using a negative pressure wound therapy system. A previously estimated wound volume may be used to detect and prevent overfill of fluid to the wound during future instillation events. For example, real-time pressure measurements may be compared to model data representative of expected pressure at a wound having a volume equal to the previously estimated wound volume, with instillation being stopped if the observed pressure varies from the expected pressure. A comparison of a total volume of fluid instilled to the wound may also be compared to the previously estimated wound volume to prevent overfill. The comparison of wound volume estimated based on an instillation event may also be compared to a wound volume estimated using other methods to provide a higher confidence wound volume estimate.