Disclosed is a dry powder inhaler for delivering medicament from at least one blister pack, each blister pack having a plurality of spaced-apart blister pockets containing doses of the medicament. The inhaler comprises: a housing for accommodating unused and used portions of the at least one blister pack together with a dispensing mechanism for simultaneously opening at least two blister pockets at a time; and a manifold component through which air can be drawn in use of the inhaler. The manifold component comprises: first and second air inlet openings for receiving external air a first air outlet opening for providing the external air to a first opened blister pocket and a first medicament inlet opening for receiving air-entrained medicament from the first opened blister pocket, the first air outlet opening and the first medicament inlet opening being arranged side-by-side to enable simultaneous communication with the first opened blister pocket; a second air outlet opening for providing the external air to a second opened blister pocket and a second medicament inlet opening for receiving air-entrained medicament from the second opened blister pocket, the second air outlet opening and the second medicament inlet opening being arranged side-by-side to enable simultaneous communication with the second opened blister pocket; and a medicament outlet opening for delivery of the air-entrained medicament from the first and second opened blister pockets to the user, the first and second medicament inlet openings being fluidly connected to the medicament outlet opening by a medicament delivery conduit formed in the manifold component. The first and second air inlet openings are fluidly connected to the first and second air outlet openings by respective first and second air conduits in the manifold component, wherein the air conduits are separately provided so that the external air from each of the first and second air inlet openings does not mix with the external air from the other of the first and second air inlet openings before reaching the first and second opened blister pockets.

An inhaler includes a main body having a canister housing, a medicament canister retained in a central outlet port of the canister housing, and a dose counter having an actuation member for operation by movement of the medicament canister. The canister housing has an inner wall, and a first inner wall canister support formation extending inwardly from a main surface of the inner wall. The canister housing has a longitudinal axis X which passes through the center of the central outlet port. The first inner wall canister support formation, the actuation member, and the central outlet port lie in a common plane coincident with the longitudinal axis X such that the first inner wall canister support formation protects against unwanted actuation of the dose counter by reducing rocking of the medicament canister relative to the main body of the inhaler.

An adherence monitor for attachment to an inhaler is disclosed. The inhaler has a drug canister, an actuator holding the drug canister, the actuator having a mouthpiece, and a dosing device operable to allow the drug canister to be actuated to release a dose. The adherence monitor includes an actuation detection sensor operable to sense the physical movement of the drug canister when actuated. An inhalation data sensor is operable to sense air pressure change created by the inhalation. A controller is coupled to the sensors to record an actuation event.

An inhaler, particularly for a horse, having a reservoir for dispensing a medicament preparation held under excess pressure, with a discharge nozzle for forming an aerosol of the medicament preparation and with a chamber for holding and temporarily storing the aerosol, which is located on the outlet side, a respiratory orifice adapter for a respiratory orifice, particularly a nostril, while according to a first aspect the reservoir is secured in position, at least in the axial direction, according to a second aspect the discharge nozzle has a direction of discharge which is inclined by more than 5° and less than 50° relative to a central axis of the reservoir or a direction of actuation for dispensing the aerosol, and according to a third aspect, the reservoir has a dispensing valve which is arranged at the top in the position of use of the inhaler.

Nasally targeted dry powder compositions and methods for their use in the treatment of exposure to organophosphate compounds including chemical warfare agents and pesticides. Compositions include anticholinergic agents and cholinesterase reactivator agents used for primary treatment and vasoactive agents and benzodiazepines used for secondary treatment of exposure, and combinations of these agents. Compositions incorporate excipients and enabling agents such as permeation enhancers, and optimal sizing of active pharmaceutical ingredient particle size to improve drug delivery across the nasal mucosa, stability, and resistance to heat degradation. Packaging and configuration of devices for dry powder nasal compositions enable their use by non-medical personnel in civilian mass casualty or battlefield environments.

A device having a body (10), a reservoir (100) axially slidable relative to the body (10), a metering valve (200), a blocking element (500), a triggering element (600), a triggering system controlled by inhalation (60), an actuating member (800) cooperating with the blocking element (500), a cover (11) with a central axial sleeve (110) with a lower axial edge (111), a push member (810) mounted in the cover around the central axial sleeve (110), and a spring (850) disposed around the central axial sleeve (110) between a bottom of the cover and the push member. The lower axial edge (111) of the central axial sleeve is deformed after assembly of the push member and the spring in order to produce a retention collar of the push member and form a pre-assembled subassembly that is fixed to the body.

A device for inhaling powder-type substances includes a mouthpiece, an insertion unit having a retaining part with an insertion means for opening a sub-region in a substance container containing the substance, and a discharge channel for the substance leading to the mouthpiece. In order to advantageously further improve a device of this type, it is proposed that two insertion units are provided, having preferably two retaining parts, which are separate from one another, which each have an insertion means, and with which the substance container can be opened in intersecting or opposing insertion directions. The device for inhaling powder-type substances also includes a plurality of substance containers that can be moved successively into an emptying position. The number of emptied or non-emptied substance containers can be displayed via a counter.

A nasal drug delivery device for delivering a plume derived from a propellant and a drug compound. The drug corn-pound is in an intranasal dosage form in the form of powder, suspension, dispersion, or liquid. The propelled intranasal dosage form is deposited within the upper nasal cavity such as the olfactory region. The drug deposited within the olfactory region is delivered to the brain avoiding the blood-brain-barrier. Hydrofluoroalkane propellant from a pressurized canister is channeled to a diffuser and drug-containing channel where the intranasal dosage form is aerosolized. The aerosolized intranasal dosage form passes through a nozzle thus delivering a plume to the user's upper nasal cavity.

An inhaler with a protective device for protecting the inhaler against removal or replacement of the cartridge, having a readiness indicator for displaying a not-ready-to-trigger state or a ready-to-trigger state, and a breath indicator. Also, an inhaler with an insert for putting the inhaler into a ready-to-trigger state and/or for breaking a tamper-proof seal.

The present invention provides an inhaler comprising a housing which contains a blister strip having a plurality of blisters which contain powdered medicament for inhalation, a mouthpiece mounted to the housing through which the medicament is inhaled by a user, an indexing and opening mechanism for indexing the blister strip and for opening the blisters which is operated by an actuator, wherein the blister strip is indexed by forward motion of the actuator from a first position to a second position, such as by opening a cover, and is also indexed in the same direction by reverse motion of the actuator from the second position to the first position, such as by closing the cover.