Provided are a method for sleep improvement obtained by regular inhalation of air containing high-concentration hydrogen, an electrolytic hydrogen generator and a portable electrolytic hydrogen generator for implementing the method. According to the method, air containing high-concentration hydrogen from a nozzle portion of a portable electrolytic hydrogen generator is inhaled through a mouth or a nose by continuously using the electrolytic hydrogen generator that releases air containing high-concentration hydrogen from the nozzle portion when necessary. The generator enables an operation while being held with one hand, the control substrate controls power supply and stop of power supply from a battery to positive and negative electrodes in response to an operation of the operation means, the control including control for supplying power for a predetermined time in response to an operation of the operation means and stopping power supply after a lapse of the predetermined time.

Provided are a method for sleep improvement obtained by regular inhalation of air containing high-concentration hydrogen, an electrolytic hydrogen generator and a portable electrolytic hydrogen generator for implementing the method. According to the method, air containing high-concentration hydrogen from a nozzle portion of a portable electrolytic hydrogen generator is inhaled through a mouth or a nose by continuously using the electrolytic hydrogen generator that releases air containing high-concentration hydrogen from the nozzle portion when necessary. The generator enables an operation while being held with one hand, the control substrate controls power supply and stop of power supply from a battery to positive and negative electrodes in response to an operation of the operation means, the control including control for supplying power for a predetermined time in response to an operation of the operation means and stopping power supply after a lapse of the predetermined time.

An aerosol device is provided for user inhalation of an aerosol stream. The device includes: an aerosol inhaler adapted for guiding the aerosol stream having a plurality of microdroplets; a non-thermal plasma jet generator adapted for generating a plasma plume of non-thermal plasma; the plasma jet generator includes an outlet for exhausting the plasma plume in the aerosol stream.

An aerosol device is provided for user inhalation of an aerosol stream. The device includes: an aerosol inhaler adapted for guiding the aerosol stream having a plurality of microdroplets; a non-thermal plasma jet generator adapted for generating a plasma plume of non-thermal plasma; the plasma jet generator includes an outlet for exhausting the plasma plume in the aerosol stream.

An aerosol-generating device includes: a housing having a liquid storage cavity for accommodating an aerosol-generating substrate; a metal element arranged outside the liquid storage cavity; a static electricity generating assembly including a positive terminal and a negative terminal, one of the positive terminal and the negative terminal being electrically connected to the metal element so as to cause a part of the aerosol-generating substrate that is close to the metal element in the liquid storage cavity to be charged by electrostatic induction when the static electricity generating assembly is electrified; and a vaporization sheet, that, when electrified, vaporizes the charged aerosol-generating substrate to generate a charged aerosol.

Systems and methods for nitric oxide (NO) generation systems are provided. In some embodiments, an NO generation system comprises at least one pair of electrodes configured to generate a product gas containing NO from a flow of a reactant gas. The electrodes have elongated surfaces such that a plasma produced is carried by the flow of the reactant gas and glides along the elongated surfaces from a first end towards a second end of the electrode pair. A controller is configured to regulate the amount of NO in the product gas by the at least one pair of electrodes using one or more parameters as an input to the controller. The one or more parameters include information from a plurality of sensors configured to collect information relating to at least one of the reactant gas, the product gas, and a medical gas into which the product gas flows.

An inhaler and a method for adjusting the inhaler for inhaling a liquid pharmaceutical formulation and an inhaler with a nozzle for use with said method. The inhaler includes a mouth piece portion with a lumen and a coupled body portion. The body portion includes a body with a base facing the lumen. The body further has a nozzle with an outlet for discharging said pharmaceutical formulation extending from the base into the lumen, a counter electrode at the base at a counter electrode distance from the nozzle outlet and a discharge electrode at a discharge electrode distance from the nozzle outlet. The inhaler further has a power supply and an air inlet. The method includes a step of adjusting the electrode(s) relative to the nozzle outlet of the inhaler.

An inhaler and a method for adjusting the inhaler for inhaling a liquid pharmaceutical formulation and an inhaler with a nozzle for use with said method. The inhaler includes a mouth piece portion with a lumen and a coupled body portion. The body portion includes a body with a base facing the lumen. The body further has a nozzle with an outlet for discharging said pharmaceutical formulation extending from the base into the lumen, a counter electrode at the base at a counter electrode distance from the nozzle outlet and a discharge electrode at a discharge electrode distance from the nozzle outlet. The inhaler further has a power supply and an air inlet. The method includes a step of adjusting the electrode(s) relative to the nozzle outlet of the inhaler.

In alternative embodiments, provided are products of manufacture fabricated or manufactured as medical devices such as an inhaler, an ionizer, an asthma “puffer-like” device, a nebulizer or a nasal spray device, a respirator or a ventilator, a warm or a hot air delivery device, and/or a CPAP (continuous positive air pressure) device (for example, for managing or treating sleep apnea) or equivalent, for delivering one or a combination of medications or drugs, and optionally also warm or hot air, and optionally also ionized air. Products of manufacture are used for treating, preventing, ameliorating, slowing the progress of, decreasing the severity of or preventing a microbial infection, such as bacterial and viral infections, including the common respiratory viruses such as influenza virus, respiratory syncytial virus, picornavirus, parainfluenza virus, adenovirus, rhinovirus, human metapneumovirus, hantaviruses, enterovirus, a coronavirus infection, or a COVID-19 or a 2019-nCoV (or so-called Wuhan coronavirus) infection, or an infection caused by a virus in the subfamily Orthocoronavirinae, or a virus in the family Coronaviridae, or a virus in the order Nidovirales. In alternative embodiments, products of manufacture as provided herein administer combinations, or cocktails, of a drug or drugs by inhalation, for example, by use of aerosol, mist, liquid or powder formulations for inhalation.

In alternative embodiments, provided are products of manufacture fabricated or manufactured as medical devices such as an inhaler, an ionizer, an asthma “puffer-like” device, a nebulizer or a nasal spray device, a respirator or a ventilator, a warm or a hot air delivery device, and/or a CPAP (continuous positive air pressure) device (for example, for managing or treating sleep apnea) or equivalent, for delivering one or a combination of medications or drugs, and optionally also warm or hot air, and optionally also ionized air. Products of manufacture are used for treating, preventing, ameliorating, slowing the progress of, decreasing the severity of or preventing a microbial infection, such as bacterial and viral infections, including the common respiratory viruses such as influenza virus, respiratory syncytial virus, picornavirus, parainfluenza virus, adenovirus, rhinovirus, human metapneumovirus, hantaviruses, enterovirus, a coronavirus infection, or a COVID-19 or a 2019-nCoV (or so-called Wuhan coronavirus) infection, or an infection caused by a virus in the subfamily Orthocoronavirinae, or a virus in the family Coronaviridae, or a virus in the order Nidovirales. In alternative embodiments, products of manufacture as provided herein administer combinations, or cocktails, of a drug or drugs by inhalation, for example, by use of aerosol, mist, liquid or powder formulations for inhalation.