System for gas treatment of cellular implants. The system enhances the viability and function of cellular implants, particularly those with high cellular density, for use in human or veterinary medicine. The system utilizes a miniaturized electrochemical gas generator subsystem that continuously supplies oxygen and/or hydrogen to cells within an implantable and immunoisolated cell containment subsystem to facilitate cell viability and function at high cellular density while minimizing overall implant size. The cell containment subsystem is equipped with features to allow gas delivery through porous tubing or gas-only permeable internal gas compartments within the implantable cell containment subsystem. Furthermore, the gas generator subsystem includes components that allow access to water for electrolysis while implanted, thereby promoting long-term implantability of the gas generator subsystem. An application of the system is a pancreatic islet (or pancreatic islet analogue) implant for treatment of Type 1 diabetes (T1D) that would be considered a bio-artificial pancreas.

The present application provides a self-powered drug-delivery device. The device includes a chamber having a wall. The chamber contains a fluid and is in connection with an administration means. The device also includes a displacement-generating battery cell. The device further includes an electrically-controlled battery unit, which includes the displacement-generating battery cell coupled to the chamber by a coupling means. The displacement-generating battery cell includes an element that changes shape as a result of charge or discharge of the battery cell so as to cause a displacement within the battery unit. The arrangement of the battery unit, the coupling means, the wall, the chamber, and the administration means is such that the displacement derived from the battery unit is conveyed by the coupling means to cause displacement of the wall of the chamber such that the fluid is expelled from the chamber to force a drug towards the administration means.

Implementations of the present disclosure are directed to conserving energy of an injection device that includes an energy source configured to power an electronic component, a priming component configured to generate a trigger, a reactant configured to generate an instantiation signal in response to the trigger, and a sensor configured to detect and process the instantiation signal and generate an activation signal to activate the energy source.

A pump assembly for pumping a medication through a cannula, said pump assembly comprising a housing adapted to be attached to a skin of a patient and containing a reservoir assembly having a variable volume liquid chamber configured to contain the medication upon filling of the reservoir assembly, a variable volume gas chamber configured to contain air before filling of the reservoir assembly and a pressure chamber configured to contain a pressure generating element, the liquid chamber, gas chamber and pressure chamber are fluidly sealed with respect to each other; the liquid chamber is selectably fluidly couplable with the cannula and the gas chamber is fluidly couplable with the atmosphere.

A device is disclosed. The device includes a housing that defines a chamber. The chamber is to be at least partially filled with an electrolyte material. The device also includes a plurality of electrodes that are at least partially embedded in the housing and exposed to the chamber. The device further includes an access port that provides fluid communication between an interior of the housing and the outside environs.

Processes and devices for delivering a fluid by decomposition of hydrogen peroxide are disclosed. Advantageously, the reaction is very fast and exothermic resulting in a fast ejection and, optionally, heating a fluid as it is ejected from a container. Also disclosed is a fluid flow system powered by a gas-generating reaction that is activated by an electrothermal activation switch.

A flushing apparatus according to embodiments of the present disclosure includes: a main body configured to connect a connection pipe for guiding a hazardous medicinal liquid harmful to a human body when exposed to an ambient air and a patient connection module for injecting the hazardous medicinal liquid into a patient, the main body configured to form a first flow path for guiding the hazardous medicinal liquid from the connection pipe to the patient connection module, the main body including a flushing portion forming a second flow path connected to a predetermined connection point located between both ends of the first flow path; and a flow rate reduction part disposed at upstream side of the connection point in the first flow path and configured to reduce a flow rate of the hazardous medicinal liquid flowing through the first flow path. The present disclosure shows various embodiments of the flushing apparatus.

A wearable drug delivery device and related methods are described. The wearable drug delivery device can include: a housing; a flexible bag disposed within the housing; a cannula in fluid communication with the flexible bag; and a pumping mechanism for forcing a drug from the flexible bag and into the cannula, wherein the pumping mechanism is proximate the flexible bag and includes a spring-loaded paddle or a driving bag.

Embodiments of this invention relate to a fluid delivery device. The fluid delivery device comprises a fluid reservoir for containing a fluid, a first drive mechanism configured to remove a predetermined amount of the fluid from the fluid reservoir when the first drive mechanism is actuated, a needle, a septum and a housing having an orifice. Also disclosed is a method for dispensing a fluid from a fluid delivery device into a patient.

Embodiments of the present invention utilize a closed-loop feedback control system to ensure accurate drug delivery. This control system may, for example, utilize a flow sensor to measure the volume of delivery and an intelligent control algorithm to anticipate and compensate for overdoses and underdoses. Feedback control systems in accordance herewith can be applied to any piston- or plunger-driven pump system utilizing sensors that measure flow directly or indirectly. In some embodiments, adjustments are made during a “priming” stage when liquid is pumped through the internal fluid path but does not exit the pump.