A user-initiated fluid pathway connection includes: a connection hub, a piercing member, a sterile sleeve, and a drug container having a cap, a pierceable seal, a barrel, and a plunger seal, wherein the piercing member is initially retained within the sterile sleeve between the connection hub and the pierceable seal of the drug container. The connection hub may include an internal aperture within the connection hub which functions as a flow restrictor and wherein a piercing member is connected to one end of the internal aperture and a fluid conduit is connected to another end of the internal aperture. A drug delivery pump with integrated sterility maintenance features includes a housing, upon which an activation mechanism, an insertion mechanism, a fluid pathway connection as described above, a power and control system, and a drive mechanism connected to a drug container are mounted. Methods of assembly and operation are also provided.

An infusion set system includes a base and a fluid connector removably coupleable thereto. The fluid connector includes a fluid path portion and at least one connector latch displaceably connected to the fluid path portion and displaceable to a latching position in which at least a portion of the connector latch extends into the fluid path portion, which includes a cannula extending from a top interior surface thereof, and a plurality of internal sidewalls corresponding to at least two of a plurality of flat side surfaces of at least one of a base section and a base latch, thereby facilitating connection between the base and the fluid connector in a plurality of discrete rotational connecting positions. When the fluid connector is locked to the base, the at least one connector latch engages a base latching portion of the base and restricts proximal displacement of the fluid connector.

The present disclosure relates to relates to medication injection devices, and in particular to systems and methods for on-demand delivery of a non-liquid medication from a wearable medication injection device. Particularly, aspects of the present invention are directed to a device that includes a housing defining a chamber, a piston disposed within the chamber, a needle disposed within the chamber on a first side of the piston, an energetic material disposed within the chamber on a second side of the piston, and a medication strip disposed within the needle. The medication strip includes an injectable substance in a non-liquid form.

A hollow needle includes a needle body made of an electrically conductive material, forming a cylindrical shape, and including a shaft part, a tip part connected with the shaft part, and an opening for discharging or drawing in a liquid in which a cavity communicating between the shaft part and the opening is formed. Also included is an annular insulating film made of an electrically insulative material, which exposes the opening and at least part of the tip part, and coats at least part of an outer circumferential surface of the shaft part.

Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface. In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent. In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent.

A method of dispensing a therapeutic fluid from a line includes providing an inlet line connectable to an upstream fluid source. The inlet line is in downstream fluid communication with a pumping chamber. The pumping chamber has a pump outlet. The method also includes actuating a force application assembly so as to restrict retrograde flow of fluid through the inlet while pressurizing the pumping chamber to urge flow through the pump outlet. A corresponding system employs the method.

A safety needle system includes a safety mechanism for a needle assembly, such as a Huber needle. A main body has a channel having a proximal end to encompass tubing and a distal end for positioning proximate a needle. The main body further has a first hinge mechanism and a first latching mechanism. A movable cover has needle receptacle, a second hinge mechanism connected with the first hinge mechanism of the main body, and a biasing member for pivoting movable cover about the first and second hinge mechanisms relative to the main body. The movable cover has a second latching mechanism to latch with the first latching mechanism in a closed position, in which the safety mechanism can be undocked from the needle and slid away from the needle along the tubing. The movable cover has a release mechanism to allow pivoting of the movable cover about the hinge mechanisms such that the needle receptacle of the movable cover at least partially receives the needle of the needle assembly in an open, locked position.

Systems and methods for automatic intravenous injection in accordance with embodiments of the invention are illustrated. One embodiment includes a method for automatically injecting a needle into a vein. The method includes steps for identifying an injection position using a first set of one or more sensors, positioning an injection mechanism at the identified injection position, and vertically inserting a needle until entry in a vein is detected using a second set of one or more sensors.

Described herein are systems and methods for performing peritoneal dialysis. According to one aspect, the disclosure provides a sterile interface connection for connecting a water purification system to a disposable source of dialysate concentrates. The sterile interface connection can include a chamber comprising an inlet adapted to be connected to the water purification system on a proximal end and a valve on a distal end. The sterile interface connection can also include spring-loaded needle disposed in the chamber. The spring-loaded needle can move between a retracted configuration in which the spring-loaded needle is fully retracted into the chamber and the valve is closed and sealed, and an extended configuration in which the spring-loaded needle extends through the valve into the disposable source of dialysate concentrates.

An infusion cannula unit made of plastic has a cannula for insertion in a blood vessel. A housing of the unit has a supply line portion the line axis of which runs at an angle relative to a cannula longitudinal axis, said angle being greater than 10°. The supply line portion is in fluid communication with a lumen of the cannula. The infusion cannula unit has a one-piece design. This results in a unit which is easy to produce and in particular suitable for mass production.