The disclosure provides improved vent filters useful in single-use in-line transfusion systems. In a first aspect, the disclosure provides filter comprising (i) a layer comprising a fluoropolymer membrane and (ii) a layer comprising at least two air-permeable thermoplastic polymeric layers, the air-permeable thermoplastic polymeric layers comprised of a first polymeric layer and a second polymeric layer, wherein the first polymeric layer is in bonded contact with the fluoropolymer membrane, possesses a melting point of about 95° C. to about 180° C., and wherein the second polymeric layer is in bonded contact with the first polymeric layer and has a melting point of about 220° C. to about 265° C. These filters exhibit excellent bonding strength between the various layers while preserving a considerable amount of the original fluoropolymer membrane air flux.

A method is provided for infusing a therapeutic. The method includes providing a microvalve device having an inner catheter longitudinally displaceable relative to an outer catheter, and a filter valve coupled to the inner catheter adjacent the distal ends of the inner and outer catheters such that longitudinal displacement of the inner catheter relative to the outer catheter permits the filter valve to be reconfigured from a first configuration to a second configuration. The filter valve is advanced to a target location in via a blood vessel in which the filter valve is configured under tension. Then in an embodiment, the tension is released and the filter valve is placed under compression. Then the therapeutic agent is infused through the inner catheter and out of the orifice of the inner catheter beyond the filter valve.

A cell transplantation device is used to place a graft containing cells into a target region in a living body. The cell transplantation device includes a needle extending in one direction, and a filter unit made of a fibrous member. The needle has a flow channel defined therein and an opening at the tip of the needle. The filter unit is disposed at an intermediate position in the flow channel and configured to retain a graft between the filter unit and the opening when a liquid material containing the graft enters the flow channel through the opening.

A method includes providing microvalve device having inner and outer catheters, and a filter valve attached to the distal end of the inner and outer catheters. Longitudinal displacement of the inner catheter relative to the outer catheter moves the filter valve from a non-deployed configuration to a deployed configuration. With the inner catheter longitudinally advanced a first amount relative to the outer catheter, the filter valve is in a reduced first diameter for advancement of a guidewire to a target location. Once the filter valve reaches the target location, the inner catheter is moved relative to the outer catheter such that the filter valve assumes a larger second diameter. A therapeutic agent is infused through the inner catheter and beyond the filter valve.

A system includes a device having inner and outer catheters, and a filter valve attached to the distal end of the inner and outer catheters. Longitudinal displacement of the inner catheter relative to the outer catheter moves the filter valve from a non-deployed configuration to a deployed configuration. The device has a first configuration in which the distal end of the inner catheter is longitudinally advanced by a first distance relative to the distal end of the outer catheter and the filter valve assumes a stretched configuration, and a second configuration in which the distal end of the inner catheter is longitudinally advanced by a second distance relative to the distal end of the outer catheter to cause the filter valve to assume a diameter larger than in the stretched configuration.

A liquid drug-filtering filter medium is provided, which can include a nanofiber web having a three-dimensional network structure for filtering foreign substances included in a liquid drug. According to the embodiment, the occurrence of differential pressure when drawing in and filtering a liquid drug is minimized, and thus the liquid drug may be quickly drawn into a syringe cylinder within a short time and by applying small force, and at the same time, the filtration rate of foreign substances in the liquid drug is very outstanding. A method for producing the liquid drug-filtering filter medium is also provided, which enables the very easy adjustment of a pore structure of the filter medium or the diameters of the pores in order to enable the pore structure to minimize the occurrence of differential pressure or change the differential pressure to a target level.

A medical product includes a bladder, a filtration device, and a sterile product concentrate. The bladder has a perimeter seal and defining a sterile chamber. The filtration device includes a stem and a filter membrane disposed in line with the stem. The stem extends through the perimeter seal and has an inlet end accessible from outside of the perimeter seal and an outlet end in fluid communication with the sterile chamber. The filter membrane can have a nominal pore size in a range of approximately 0.1 m to approximately 0.5 m, wherein the filter membrane is shaped as a hollow fiber with a wall and pores residing in the wall of the fiber. The sterile product concentrate is disposed in the sterile chamber and adapted to be reconstituted by the introduction of a pharmaceutical fluid into the chamber through the filtration device.

A medical product includes a bladder, a filtration device, and a sterile product concentrate. The bladder has a perimeter seal and defining a sterile chamber. The filtration device includes a stem and a filter membrane disposed in line with the stem. The stem extends through the perimeter seal and has an inlet end accessible from outside of the perimeter seal and an outlet end in fluid communication with the sterile chamber. The filter membrane can have a nominal pore size in a range of approximately 0.1 ?m to approximately 0.5 ?m, wherein the filter membrane is shaped as a hollow fiber with a wall and pores residing in the wall of the fiber. The sterile product concentrate is disposed in the sterile chamber and adapted to be reconstituted by the introduction of a pharmaceutical fluid into the chamber through the filtration device.

The present disclosure relates to a filter module for a medical fluid delivery system capable of removing cytokine inducing substances (CIS) from a medical fluid.

A liquid drug-filtering filter medium is provided, which can include a nanofiber web having a three-dimensional network structure for filtering foreign substances included in a liquid drug. According to the embodiment, the occurrence of differential pressure when drawing in and filtering a liquid drug is minimized, and thus the liquid drug may be quickly drawn into a syringe cylinder within a short time and by applying small force, and at the same time, the filtration rate of foreign substances in the liquid drug is very outstanding. A method for producing the liquid drug-filtering filter medium is also provided, which enables the very easy adjustment of a pore structure of the filter medium or the diameters of the pores in order to enable the pore structure to minimize the occurrence of differential pressure or change the differential pressure to a target level.