A device for preventing contamination of a positive-pressure connector (6) of an indwelling needle and a method based on same. The device comprises a shell (1), a connecting port (3) fixedly connected to the shell (1) and used for connecting to the positive-pressure connector (6), an air pressure balance hole (5) disposed opposite to the connecting port (3) and provided on the shell (1), and a filtering membrane (2) provided between the air pressure balance hole (5) and the connecting port (3). The device is simple in structure, adopts a structural design of the filtering membrane (2), can filter microorganisms, bacteria, viruses, dusts, and particulate pollution sources, and is used during indwelling of infusion intervals to prevent the positive-pressure connector (6) from being exposed to the air and maintain the aseptic state and positive-pressure condition of the positive-pressure connector (6) during indwelling.

A syringe system includes a syringe and a filtration device connected to the syringe for sterilizing and introducing fluid into the syringe. The syringe includes a syringe barrel having a proximal end defining a barrel opening, a distal end defining a delivery opening, a bore extending between the proximal end and the distal end, and a stopper disposed in the bore of the syringe barrel. The filtration device has an inlet and an outlet coupled in fluid communication with the delivery opening at the distal end of the syringe barrel. The filtration device includes a stem and a filter membrane disposed in line with the stem. The filter membrane optionally has a plurality of pores each with a nominal pore size in a range of approximately 0.1 μm to approximately 0.5 μm such that a pharmaceutical fluid can be introduced as a sterilized pharmaceutical fluid into the bore of the syringe barrel by passing through the filtration device.

A drip chamber insert may include an elongate body portion comprising an upper surface, and a base portion positioned downstream of the elongate body portion for coupling to a drip chamber. The base portion may have an upper surface and a lower surface defining an outlet orifice of the drip chamber insert. The drip chamber insert may further include a first chamber and a second chamber. The first chamber may be disposed in the elongate body portion and fluidly coupled to the upper surface via an inlet orifice and to the outlet orifice via the base portion. An anti-run-dry membrane may be disposed on the upper surface of the elongate body portion extending over the inlet orifice. The second chamber may be disposed in the elongate body portion extending from the upper surface to the base portion. A low flowrate orifice may extend from a base of the second chamber into the base portion for fluidly coupling the second chamber with the outlet orifice.

Presented herein are methods, systems, and apparatus for administering an antibody treatment via an infusion device, e.g., a rapid infusion device, e.g., for the treatment of a disease or condition that requires one or more infusions of monoclonal and/or polyclonal antibodies.

Modular intravenous (IV) assemblies are provided. The modular IV assembly includes a drip chamber having a body and an inlet connector, a base housing coupled directly to a base portion of the drip chamber, the base housing having an inlet port in fluid connection with the drip chamber and a flow path cavity in fluid connection with the inlet port and a flow control assembly coupled directly to a first portion of the base housing. Any of a filter assembly, an anti-run dry member, a check valve and an air vent assembly may be included in the modular IV assembly. IV sets and methods of use are also provided.

The disclosure provides improved vent filters useful in single-use in-line transfusion systems. In a first aspect, the disclosure provides filter comprising (i) a layer comprising a fluoropolymer membrane and (ii) a layer comprising at least two air-permeable thermoplastic polymeric layers, the air-permeable thermoplastic polymeric layers comprised of a first polymeric layer and a second polymeric layer, wherein the first polymeric layer is in bonded contact with the fluoropolymer membrane, possesses a melting point of about 95° C. to about 180° C., and wherein the second polymeric layer is in bonded contact with the first polymeric layer and has a melting point of about 220° C. to about 265° C. These filters exhibit excellent bonding strength between the various layers while preserving a considerable amount of the original fluoropolymer membrane air flux.

The present invention relates to a filter laminating structure for an intravenous infusion filter that is capable of allowing a filter body to be supported against a filter type of support body, thereby preventing the filter body from being broken or damaged even by the injection of medicine under high pressure, and the filter laminating structure including an upper filter housing having a medicine injection hole adapted to inject medicine therethrough, a lower filter housing coupled to the underside of the upper filter housing, a filter body located at an upstream side in the flow of the medicine injected into the medicine injection hole to perform a filtering function for the medicine, and a support body located at a downstream side in the flow of the medicine on the underside of the filter body to support the filter body thereagainst.

Methods of preparing a drug for delivery and drug delivery systems for achieving the same are disclosed. A method of preparing a drug for delivery may include providing a diluent contained in a diluent container and providing a drug product contained within a drug product container. The method may further include fluidly connecting the diluent container and the drug product container. Additionally the method may include urging, via a pump, at least a portion of the diluent from the diluent container into the drug product container to at least partially reconstitute the drug product.

A liquid delivery system includes an air elimination assembly disposed in a pathway between a liquid source and a recipient. As its name suggests, the air elimination assembly removes gas from the liquid as it flows between an input port and output port of the air elimination assembly. A magnitude of pressure at the gas output port of the air elimination assembly is controlled to expel gas from the liquid passing from the input port to the output port. The gas expelled from the liquid is outputted from the gas output port. The liquid delivered to the recipient is void of any gases.

Modular intravenous (IV) assemblies are provided. The modular IV assembly includes a drip chamber having a body and an inlet connector, a base housing coupled directly to a base portion of the drip chamber, the base housing having an inlet port in fluid connection with the drip chamber and a flow path cavity in fluid connection with the inlet port and a flow control assembly coupled directly to a first portion of the base housing. Any of a filter assembly, an anti-run dry member, a check valve and an air vent assembly may be included in the modular IV assembly. IV sets and methods of use are also provided.