A drug delivery system for injecting a medicament includes a housing defining a cavity, a container received within the cavity and configured to receive a medicament, the container comprising a stopper configured to move within the container and a closure, a drive assembly received within the cavity and configured to drive the stopper within the container, a needle actuator assembly received within the cavity and comprising a needle configured to be placed in fluid communication with the container, the needle moveable from a first position and a second position spaced from the first position, and a sterilizer received within the cavity and configured to sterilize at least one of the container, the drive assembly, and the needle actuator assembly upon activation of the drug delivery system.

An injection needle assembly (50) for an injection device, comprising: a) a needle cannula (3) attached to a needle hub (4) and defining a pointed tip at a free end (3a, 3b), and b) a needle cover (10, 10a, 10b) forming an axially extending elongated flexible enclosure accommodating the needle cannula (3). The needle cover (10, 10a, 10b) is configured to axially collapse and become penetrated by the needle cannula (3) when a penetration force is applied to the needle cover. The needle cover (10, 10a, 10b) defines a shaft section (11a) and a bulb section (11b). The shaft section (11a) encircles the needle cannula (3) and extends axially from the needle hub (4) to the bulb section (11b). The shaft section (11a) comprises wall areas of minimum wall thickness t.sub.1 whereas the bulb section (11b) comprises wall areas (17a, 17b) having a wall thickness t.sub.2 larger than said minimum wall thickness t.sub.1. The shaft section (11a) comprises one or more reinforcing ribs (16), each reinforcing rib extending non-parallel to the needle axis so as to at least partly encircle the needle cannula (3), wherein each reinforcing rib (16) divides adjoining annular collapse regions (15) of the shaft section (11a).

An injection device (100), including a base (104), a sliding body (116) slidably connected to the base (104), a double-ended needle (120) fixed to the sliding body (116), a biasing member (124) for proximally biasing the sliding body (116) with respect to the base (104), and for retracting the needle (120) into the device (100) subsequent to activation of the device (100), a medicament cartridge (128) for holding a medicament, slidably connected to the sliding body (116), and a stopper (132) slidably disposed within the medicament cartridge (128). The base (104) has a proximal end (108) and a surface (164) disposed at a distal end (112) thereof for contacting a patient's skin. The base (104) also has a first locking mechanism. The sliding body, (116) has a locking feature and a second locking mechanism. The second locking mechanism locks the medicament cartridge (128) relative to the sliding body (116) upon completion of displacement of the medicament cartridge (128) relative to the sliding body (116). The first locking mechanism and the locking feature interact to lock the sliding member (116) relative to the base subsequent to retraction of the needle (120) into the device (100).

A needle unit (20) comprising: a needle hub (21) comprising a needle (23) and a needle shield (22), wherein the needle hub (21) and the needle shield (22) are arranged to form a needle unit (20) where the needle hub is arranged displaceably inside the needle shield such that the needle hub is displaceable along an axis which is parallel with the longitudinal axis of the needle (23) between a shielded position and an exposed position. The needle hub (21) further comprises a first hub locking element (24) and a second hub locking element (26) and the needle shield (22) further comprises a first shield locking element (25) and a second shield locking element (27), said first hub locking element (24) and said first shield locking element (25) engaging each other in the shielded position to establish a first releasable locking mechanism (24, 25) between the needle hub (21) and the needle shield (22), said second hub locking element (26) and said second shield locking element (27) engaging each other in the shielded position to establish a second locking mechanism (26, 27) between the needle hub (21) and the needle shield (22), both the first and second locking mechanisms (24, 25, 26, 27) being arranged as shock proof locks, and where the first releasable lock mechanism (24, 25) is arranged to engage with the lock release element (31) of the injection device (1) when the needle unit (20) is coupled to the injection device, said engagement allowing the first releasable lock mechanism (24, 25) to be unlocked. The invention further provides an injection device comprising the needle unit and a method of assembling an injection device with the needle unit.

An autoinjector (100′) for expelling a single dose of a drug from a held cartridge (600) comprising a piston (630). The autoinjector includes a needle shield (350, 380′) axially movable from an initial extended position via a triggering position to a trigger release position. The needle shield (350, 380′) is operatively coupled to a plunger release element (320′, 1320) cooperating with a plunger (310, 400) to define a releasable retaining mechanism that retains the plunger release element (320′, 1320) threadedly engaged with a base thread component (204′, 1204) in a predefined relative rotational and axial position and against rotational bias provided by an actuator (330). The needle shield (350, 380′) is configured for operating the retaining mechanism to release the retaining of the plunger release element (320′, 1320) and the base thread component (204′, 1204) from the predefined relative rotational and axial position upon the needle shield (350, 380′) being moved into the trigger release position.

The present disclosure relates to an injection needle assembly for use in a medicament delivery device. The injection needle assembly comprises an injection needle holder, an injection needle fixed to said injection needle holder, the injection needle having a proximal end and a distal end, and a sealing assembly for sealing the distal end of the injection needle. The sealing assembly comprises a spacer element surrounding the distal end of the injection needle and a sealing membrane for sealing the distal end of the injection needle.

A method of manufacturing one of a range of autoinjectors having cartridges (600, 600′, 600″) with different preset fill volumes, the method comprising the steps of: a) providing a front body assembly (100b, 100c, 100c′, 100c″), b) providing a cartridge (600, 600′, 600″) of given fill volume, c) providing a rear body assembly (100a) comprising a spring-driven drive ram assembly (310, 320) configured to drive the piston of a held cartridge (600, 600′, 600″), d) providing a ram spacer member (400, 400′, 400″), the ram spacer member defining a spacing geometry of length dimension (X1′, X1″, X1′″, XS′, XS″, XS′″, XR′, XR″, XR′″) selected according to the fill volume of the cartridge (600, 600′, 600″), and e) assembling a front body assembly (100b, 100c, 100c′, 100c″), the cartridge (600, 600′, 600″), the ram spacer member (400, 400′, 400″) and the rear body assembly (100a) so that the ram spacer member (400, 400′, 400″) is arranged axially between the drive ram assembly (310, 320) of the rear body assembly (100a) and the piston of a held cartridge (600, 600′, 600″).

The invention relates to an activating mechanism for a medicament delivery device (1), comprising: —an outer body (8), —a cartridge (2) containing a dosage of a medicament and sealed with a sealing element (2.1) that is arranged across an open distal end of the cartridge (2), —a cartridge carrier (4) adapted to hold the cartridge (2), —a needle safety mechanism adapted to hold a double-ended hollow needle (6) and to relatively move along a longitudinal axis (L) with respect to the cartridge (2) and to the outer body (8) to cover or to expose the needle (6), —wherein in an initial position (P1) of the medicament delivery device (1), the double-ended hollow needle (6) is spaced from the cartridge (2) in a distal direction (D), and —wherein when the needle safety mechanism is pressed into the outer body (8), a proximal end of the needle (6) pierces the sealing element (2.1). The invention further relates to a medicament delivery device (1) comprising such an activating mechanism.

A device (1) for dispensing a substance to a patient comprising a cylindrical first container (2) containing the substance and a second container (3) containing a liquid. The device further comprises an injection device (4) and transfer mechanism (5) for transferring the liquid from the second container (3) to the first container (2) and from the first container (2) to the injection device (4). The first container (2) has a connection element (7) and a plunger (9) that can be moved between the first (6) and second ends (8). By moving the plunger (9) towards the first end (6), liquid contained therein can be dispensed via the injection device (4). The injection device (4) comprises a piercing cannula (15) and an indwelling cannula (16). In an initial position, a distal end region of the piercing cannula (15) extends coaxially in the interior of the indwelling cannula (16).

A medicament delivery device (100) for delivery of medicament through a cannula (132) from a cartridge (10), the device comprising a first container (11) for storage of a first substance, a second container (12), and valve means for closing a distal end of the second chamber (12), the second container (12) being arranged coaxially with respect to the first container (11), a mixing element (304) being provided for causing displacement of the second substance into the first container (11) through the valve means in a mixing stroke, a release element being provided for holding the mixing element (304) in an initial position and being operable to release the mixing element (304) to initiate the mixing stroke, there being a needle shroud (400) for shrouding the cannula, and removal of the needle shroud (400) from the cannula (132) causing operation of the release element.