An injection needle assembly (50) for an injection device, comprising: a) a needle cannula (3) attached to a needle hub (4) and defining a pointed tip at a free end (3a, 3b), and b) a needle cover (10, 10a, 10b) forming an axially extending elongated flexible enclosure accommodating the needle cannula (3). The needle cover (10, 10a, 10b) is configured to axially collapse and become penetrated by the needle cannula (3) when a penetration force is applied to the needle cover. The needle cover (10, 10a, 10b) defines a shaft section (11a) and a bulb section (11b). The shaft section (11a) encircles the needle cannula (3) and extends axially from the needle hub (4) to the bulb section (11b). The shaft section (11a) comprises a collapsible wall area (15) having wall thickness t.sub.1 less than a predefined wall thickness t.sub.1,lim to provide radial deformability for abutting contact with the needle cannula (3). The bulb section (11b) comprises a wall area (17a, 17b) having a wall thickness t.sub.2 being greater than said predefined wall thickness t.sub.1,lim, and further defines a central end wall area (20) having a wall thickness t.sub.3 smaller than the wall thickness t.sub.2. In an initial non-penet-rated state, the needle cover (10, 10a, 10b) assumes a first configuration wherein the wall areas of the bulb section (11b) and the wall areas of the shaft section (11a) are spaced apart from the needle cannula (3).

A drug delivery system for injecting a medicament may include a housing defining a cavity, a container received within the cavity and configured to receive a medicament with the container including a closure, a valve assembly received within the cavity and including a piercing member configured to pierce the closure of the container, and a connector arrangement provided between the container and the valve assembly, the connector arrangement movable between a first, pre-use position maintaining sterility between the closure of the container and the valve assembly and a second, use position permitting fluid communication between the container and the valve assembly.

A drug delivery system includes a drug containing device and a drug delivery device. The drug containing device includes a chamber carrying a fluid drug and an outlet in fluid communication with the chamber. A first closure initially inhibits the fluid drug from exiting the drug containing device via the outlet. The drug delivery device includes a fluid passageway and a stem having an inlet in fluid communication with the fluid passageway. The stem displaces the first closure from the outlet and enters the outlet to provide fluid communication between the chamber and the fluid passageway and thereby facilitates delivery of the fluid drug to the drug delivery device. A second closure is coupled to the stem, and the second closure engages the first body at the outlet when the stem enters the outlet to inhibit the fluid drug from exiting the drug containing device around the stem.

A drug injection device is disclosed. A drug injection device, according to the present invention, comprises: an injection unit which is provided with an ampoule accommodation portion for accommodating an ampoule that contains an injectable solution, and injects the injectable solution into a person being operated on; and an injection speed adjustment unit which is connected to the injection unit, applies pressure to the injectable solution, and adjusts the injection speed of the injectable solution, being injected into the body of the person being operated on, by selectively adjusting the speed of the pressure applied to the injectable solution, wherein the injection speed adjustment unit comprises: an injection unit attachment portion to which the ampoule accommodation portion is detachably attached; a pressurizing plunger which is connected to the ampoule accommodated in the ampoule accommodation portion and applies pressure to the injectable solution; and a pressurizing plunger up/down driving module which is provided on the same axis as the pressurizing plunger and drives the pressurizing plunger up or down.

Core annular flow is used to enable the subcutaneous delivery of a viscous fluid such as a protein therapeutic formulation. The high-viscosity fluid is surrounded by a low-viscosity fluid, and the low-viscosity fluid lubricates the passage of the high-viscosity fluid. This allows the use of protein formulations that have a higher concentration and a higher viscosity at comparatively reduced injection forces and reduced injection times. Several different embodiments of injection devices that provide core annular flow are described herein.

An injector includes an injector housing, an activation button assembly translatable from an unactuated position to an actuated position and a cartridge door movably mounted to the injector housing between an open position and a closed position. A deflectable interference member has a resting position configured to limit an insertion depth of a cartridge into an interior channel of the cartridge door to a sealed position, wherein the cartridge piercing needle does not fully penetrate a pierceable septum of the cartridge. Movement of the activation button assembly from the unactuated position to the actuated position thereof, in the closed position of the cartridge door, deflects the interference element out of the resting position thereof, thereby enabling further advancement of the cartridge into the interior channel of the cartridge door to an unsealed position, wherein the cartridge piercing needle fully penetrates the pierceable septum.

A drug self-delivery device comprising a body portion containing a drug vial and a needle assembly, where the body portion is slidably engaged to a trigger portion. When engaged by a user pressing the trigger portion against the user's flesh, the needle assembly relative to the drug vial so as to align a needle port with an integral drug delivery port connected to the drug vial thereby allowing fluid flow of medication through the needle. Seals engaged by a penetration spring prevent loss of medication and prevent the need for direct connection between the needle assembly and the drug vial.

A drug delivery system for injecting a medicament may include a housing defining a cavity, a container received within the cavity and configured to receive a medicament with the container including a closure, a valve assembly received within the cavity and including a piercing member configured to pierce the closure of the container, and a connector arrangement provided between the container and the valve assembly, the connector arrangement movable between a first, pre-use position maintaining sterility between the closure of the container and the valve assembly and a second, use position permitting fluid communication between the container and the valve assembly.

Apparatus for removably attaching a syringe to a container for extracting fluid therefrom into the syringe, which is particularly beneficial for fluid having a relatively high viscosity. The disclosed container adapter holds a syringe adapter securely therein (the syringe adapter configured for providing a fluid path between a container and a syringe) while also securing the syringe adapter to the container, and provides an attachment point for securely attaching the syringe to the syringe adapter and thus to the container (at least) while the fluid is withdrawn from the container into the syringe. The syringe is removably attached to an end of the syringe adapter during the withdrawal, and a cap is provided that closes entry and exit to this attachment point when the syringe is not in place. The cap preferably attaches to the syringe adapter using a connection that mimics the connection used by the syringe.

Core annular flow is used to enable the subcutaneous delivery of a viscous fluid such as a protein therapeutic formulation. The high-viscosity fluid is surrounded by a low-viscosity fluid, and the low-viscosity fluid lubricates the passage of the high-viscosity fluid. This allows the use of protein formulations that have a higher concentration and a higher viscosity at comparatively reduced injection forces and reduced injection times. Several different embodiments of injection devices that provide core annular flow are described herein.