The disclosure relates to a syringe, comprising a syringe body with a nozzle and a threaded connection. The syringe body comprises a side wall and a front wall, wherein the syringe body comprises a cycloolefin as a first material, at least in portions. The first material forms an internal wall of the syringe body. The threaded connection comprises, at least in portions, as a second material a material other than the cycloolefin, wherein the first and the second material are integrally bonded to one another. The second material extends in the region of the front wall at least in portions over the first material, so that the front wall comprises, at least in portions, a two-layer region. The first and the second material in the two-layer region have a mutually engaging structure.

Provided are a syringe assembly and a liquid-medicine administration device configured to suppress a variation in a pressure limit of a seal member. In the syringe assembly, the seal member is pressed and held between a pressing surface of a cap and a sealing surface of a distal nozzle portion of a syringe. The seal member is pressed and held in the axial direction in a pressing space over the whole region of an opposing portion between the pressing surface and the sealing surface, and a gap between the pressing surface and the sealing surface in the pressing space is narrowest on the inner peripheral side.

A gas sterilizable syringe includes an enclosure having walls that define a fluid chamber. A flowable material is disposed within the fluid chamber of the enclosure. A plunger is assembled with the enclosure and is moveable toward a distal end of the enclosure for dispensing the flowable material. One or more apertures are formed in at least one of the walls of the enclosure. A gas permeable barrier covers at least one of the apertures formed in at least one of the walls of the enclosure for enabling sterilization gases to pass through the at least one aperture covered by the gas permeable barrier while preventing the flowable material from passing through the at least one of aperture. The gas permeable barrier is permeable to the sterilization gases and impermeable to the flowable material disposed within the fluid chamber of the enclosure.

Devices and methods for sterilizing the outer and inner surfaces of a working end-site of a medical device such as a catheter hub, luer connector, luer component, needleless access site, and/or access port are discussed. The sterilizing device can include a housing, a sterilizing element including an antipathogenic agent configured for sterilizing the working end-site of a medical device, and a cap hingedly coupled to the housing and configured to hermetically seal the sterilizing element within the housing. One or more features on the cap and housing serve to hermetically seal the cap to the housing prior to use.

In a syringe, which is a prefilled syringe, when a cap body is attached to a cylindrical portion, a first sealing section is compressed radially inward by an inner peripheral surface constituting an opening of the cylindrical portion, thereby sealing a distal end section of a flow path in a liquid-tight manner, and a second sealing section is compressed radially inward by an inner peripheral surface of a proximal end section of the cylindrical portion, thereby sealing a proximal end section of the flow path in a liquid-tight manner.

Provided is a fluid wicking tip. The fluid wicking tip includes a plurality of drip flanges arranged to wick fluid between narrow spaces defined between any two drip flanges. The narrow spaces are dimensioned to facilitate wicking by capillary action. Also provided is a syringe that includes the fluid wicking tip. Also provided is a modular syringe system that includes a syringe and a sleeve configured to be slidably disposed over the syringe.

Devices and methods for sterilizing the outer and inner surfaces of a working end-site of a medical device such as a catheter hub, luer connector, luer component, needleless access site, and/or access port are discussed. The sterilizing device can include a housing, a sterilizing element including an antipathogenic agent configured for sterilizing the working end-site of a medical device, and a cap hingedly coupled to the housing and configured to hermetically seal the sterilizing element within the housing. One or more features on the cap and housing serve to hermetically seal the cap to the housing prior to use.

A syringe assembly including a plunger rod having a first end, a second end, and a rod portion extending therebetween, wherein at least a portion of the rod portion is flexible is disclosed. The flexible portion of the rod portion allows a stopper to be moved between a first position and a second position within a syringe barrel while the overall length of the syringe assembly remains the same throughout the movement between the first position and the second position. In another embodiment, a syringe assembly including a restraining member adapted to communicate with the flexible portion of the rod portion such that movement of the first end of the plunger rod in a first direction actuates movement of the second end of the plunger rod in a second direction different than the first direction is disclosed.

Provided is a syringe formulation that is pre-filled with botulinum toxin, which allows easy control of a discharge rate and may be stable.

Implementations of the present disclosure are directed to a sealing of a medicament reservoir for a drug delivery device. The drug delivery device includes a reservoir, a stopper and a sealing system. The reservoir includes a wall defining a distal end, a proximal end, and a proximal closure. The stopper is configured to expel a portion of a medicament stored within the reservoir by moving within the reservoir in a direction from the distal end to the proximal end, such that a stopper position is indicative of an amount of the medicament within the reservoir. The sealing system is configured to form a liquid tight seal between the proximal closure and the injection needles such that expelling the portion of the medicament comprises directing substantially all of the portion of the medicament from the reservoir into the injection needles.