A medical syringe useful for administering an injection or withdrawing a bodily fluid, the syringe comprising a barrel, plunger assembly and a needle assembly having a selectively retractable needle, the plunger assembly further comprising a plunger handle with a plunger seal and a front tip extending forwardly of the plunger seal to extend through the barrel and into the an annular fluid seal disposed in a recess between the barrel and a forwardly projecting needle, thereby reducing dead space inside the syringe and helping anchor the annular fluid seal inside the recess.

A drug delivery device is disclosed, wherein the device comprises a housing; a product container arranged in the housing; a plunger rod partially disposed inside the product container; and a thumb pad configured to receive a portion of the plunger rod, wherein the thumb pad and the plunger rod are configured to transition from a first state to a second state, wherein at the first state, the plunger rod is prevented from moving in a proximal direction, and at the second state, the plunger rod moves freely in a proximal direction.

A plunger for an injector to inject an intraocular lens into the capsular bag of an eye has a deformable cushion and a contact surface with a cutout in which an imaginary reference point is arranged. The plunger has two points groups, each having a design point arranged on an outer contour, an inner contour point arranged on an inner contour, and a reference point. For each of the point groups, the distance from the design point to a circle or a closed curve is equal to the distance from the inner contour point to the reference point, the design point, the inner contour point and the reference point lie on a straight line, and the inner contour point lines between the design point and the reference point. The distance from the inner contour point to the reference point is different for at least two of the point groups.

An injection device includes one or more of a barrel having an open proximal end, an open distal end, and a sidewall therebetween; a plunger; and a conduit or connector. The barrel may be configured to house a volume of therapeutic agent. The plunger may have a proximal end, a distal end, and an elongate body. The conduit or connector may be operably attached to the open distal end of the barrel. The distal end of the barrel can include a variable inner diameter segment configured such that movement of the plunger to the variable inner diameter segment of the distal end of the barrel creates an audible and/or tactile feedback sensation to a user.

The invention relates to a method for reducing an amount of sub visible particles in a pharmaceutical composition contained in a medical injection device comprising a container (1) including a barrel (10) lubricated with a lubricant coating (2) in contact with the pharmaceutical composition, and a stopper (14) in sliding engagement within the barrel (10), the container comprising a region (130, 121, 123) extending distally from the distal end (100) of the barrel which is not accessible to the stopper. During formation of said lubricant coating (2) on the inner wall of the barrel, the method comprises limiting lubricant from being deposited into said region (130, 121, 123) extending distally from the distal end (100) of the barrel.

A drug delivery device is provided herein, the device including a reservoir for containing a medicament. The medicament includes a suspension of solids in a liquid carrier. The device also includes a needle having a distal end for injection into a patient, a proximal end in communication with the reservoir, and a lumen extending between the distal and proximal ends. A path is defined from the reservoir to the distal end of the needle through the lumen, the path having an inner diameter that decreases in a proximal to distal direction along at least a portion thereof. Advantageously, with the subject invention, a flow path may be defined which provides a more gradual transition in diameter from the reservoir to a distal tip of the needle. In this manner, changes in velocity of the suspension may be less abrupt than in the prior art, thus better maintaining solid particles in the suspension.

An injection system comprising a syringe barrel; a first sealing element and a second sealing element moveably disposed in the syringe barrel; an injection chamber between them; a puncture element extending from the first sealing element to deliver an injection agent from the injection chamber into a biological space, wherein one or more of the syringe barrel, the first or the second sealing element are configured to prevent proximal movement of the first sealing element past a pre-selected location, while allowing the second sealing element to come in contact with the first sealing element, the system is configured such that, when a force is applied on the second sealing element in a distal direction, in response to a first opposing force, the puncture element advances and in response to a second opposing force, the puncture element remains stationary and the injection agent is conveyed through the puncture element.

A reduced profile syringe assembly is provided that includes an overall profile that is substantially similar to a profile of a syringe barrel. The syringe assembly includes a plunger rod that is significantly disposed within the syringe barrel when filled for use, with the plunger rod adapted to be retracted from the syringe barrel during dispensing of contents of the syringe barrel.

A stopper includes a main body portion defining an open rearward end configured to receive the plunger rod, an engagement portion provided along an inner circumference of the main body portion configured to engage at least a top portion of the plunger rod, a closed front end forming a flexible roof, and a first perimetrical skirt extending around an outer circumference of the main body portion toward the closed front end of the main body portion. When fluid pressure is increased inside the syringe barrel during an injection, the flexible roof expands in a radial direction toward an inner wall of the syringe barrel, the first perimetrical skirt is forced against the inner wall of the syringe barrel, and an engagement between the plunger rod and the engagement portion forces the main body portion to expand in the radial direction toward the inner wall of the syringe barrel.

A reduced profile syringe assembly is provided that includes an overall profile that is substantially similar to a profile of a syringe barrel. The syringe assembly includes a plunger rod that is significantly disposed within the syringe barrel when filled for use, with the plunger rod adapted to be retracted from the syringe barrel during dispensing of contents of the syringe barrel.