Systems and methods are provided to combine multiple stimulation modalities to significantly increase the effectiveness of non-invasive stimulation. Multiple sensor and stimulation devices and modalities can be combined into a single, compact unit that minimizes the need for additional sensors or stimulation devices. The system features several subunits, referred to as sensory and stimulation devices (SSD), that are integrated into a headphone setup. The system is controlled by a centralized controller that communicates with all of the SSDs and with an external computer system that delivers learning material synchronized with the delivery of stimulations and the collection of user responses based on physiological signals.

Disclosed herein are systems and methods for increasing performance, improving sleep and improving relaxation that involve specifically coordinating nerve stimulation of a cranial nerve (e.g. vagus nerve) in conjunction with augmented reality (AR). According to certain embodiments disclosed are systems that include an AR component that presents information or a stimulus and provides cranial nerve fiber stimulation (CNFS) at strategic times to reduce anxiety/arousal/related during user activity or scenarios and reinforce learning.

A system that assists acupuncture based on the physiological signals of the human body. Physiological signals comprise respiratory signals, electrocardiographic signals, electrical skin signals, electroencephalograph signal, blood flow signals, pulse wave signals and/or signals derived from above signals. The acupuncture treatment process comprises the following: controlling the actuator of the automatic acupuncture device through physiological signals to start, to stop acupuncture treatment or to perform acupuncture techniques such as twisting or lifting-thrusting. It also provides an automatic acupuncture system to assist acupuncture based on Chinese Medicine Body Clock information.

A vestibular neurostimulation device, which may include first and second electrodes; first and second thermoelectric devices thermally coupled, respectively, to first and second earpieces that are configured to be insertable into respective ear canals of a patient; and a controller comprising a waveform generator. The waveform generator may be is configured to deliver a modulated electric signal to the patient through galvanic vestibular stimulation (GVS) using the first and second electrodes and to deliver a time varying thermal waveform to the patient through caloric vestibular stimulation (CVS) using the first and second earpieces simultaneous with the delivery of the modulated electrical signal through GVS. The CVS and/or GVS may be configured to increase a passage of insulin-like growth factor 1 (IGF-1) through a blood-brain-barrier.

A system and method for a cloud-based gaming platform with integrated health-related data collection capabilities. In an embodiment, the system and method comprise a cloud-based gaming platform comprising a frontend accessible from various game clients which operates a gaming environment on one or more game servers, a backend that provides the game database and analytics used by the game servers to operate the gaming environment, and a HIPPA-compliant security gateway configured to route health-related data from gaming to a healthcare diagnostics and treatment module integrated into the platform. Exercising on an exercise machine compatible with the cloud-based gaming platform entertains the user while simultaneously capturing data about the user's physical and mental performance which can later be used to diagnose medical conditions and, depending on configuration, implement treatment regimens comprising exercise routines and mental simulation via tasks in the gaming environment.

Disclosed is a method of enhancing exposure therapy including providing an exposure therapy to a patient and stimulating the patient's vagus nerve at the same time as the exposure therapy. Also disclosed is a post-traumatic stress disorder therapy method including providing an exposure event to a patient and stimulating the patient's vagus nerve during the exposure event. Also disclosed is a phobia disorder therapy method including providing an extinction event to a patient and stimulating the patient's vagus nerve during the exposure event. Also disclosed is an obsessive compulsive disorder therapy method including providing a therapy event to a patient and stimulating the patient's vagus nerve during the therapy event. Also disclosed is an addiction disorder therapy method including providing a therapy event to a patient and stimulating the patient's vagus nerve during the therapy event.

Systems and methods for improving behavioral therapies encompassing therapies wherein a perceptual stimulus is administered to a subject or a motor behavior is performed by the subject. Such administration of perceptual stimuli or motor performance is paired with the delivery of vagus nerve stimulation to the subject. The vagus nerve stimulation is timed with the sensory stimulus administration or motor performance in a temporal alignment that maximizes neuroplasticity and performance. Systems for performance of the method and associated software are also disclosed

A cloud-based healthcare diagnostic and treatment platform capable of making non-invasive healthcare diagnostics and treatment recommendations based on data captured from combinations of physical activity and mental activity. In an embodiment, the system and method comprise a healthcare diagnostics and treatment module comprising a HIPPA-compliant security gateway, an AI-assisted healthcare diagnostics module, and an alert and treatments module. The HIPPA-compliant security gateway separates out health-related data from streams of data which may include other data such as game data, provides the health-related data to the AI-assisted healthcare diagnostics module which performs diagnoses of the health-related data using machine learning algorithms, and provides the diagnoses to the alert and treatments module which generates alerts and treatments based on the diagnoses.

A method and method for a cloud-based gaming platform with integrated healthcare diagnostic and treatment capabilities. In an embodiment, the system and method comprise a cloud-based gaming platform comprising a frontend accessible from various game clients which operates a gaming environment on one or more game servers, a backend that provides the game database and analytics used by the game servers to operate the gaming environment, and a healthcare diagnostics and treatment module integrated into the platform comprising a HIPPA-compliant security gateway, an AI-assisted healthcare diagnostics module, and an alert and treatments module. Exercising on an exercise machine compatible with the cloud-based gaming platform entertains the user while simultaneously capturing data about the user’s physical and mental performance which can be used to diagnose medical conditions and, depending on configuration, implement treatment regimens comprising exercise routines and mental simulation via tasks in the gaming environment.

Sleep performance systems and methods of using the same are disclosed. The sleep performance systems can improve the quality of sleep by making one or more recommendations to the subject for increasing a sleep quality score. The sleep performance systems can have one or more electroencephalography (EEG) electrodes configured to measure a subject's brain activity during sleep. The sleep performance systems can have a processor configured to quantify the quality of the subject's slow-wave sleep by determining one or more sleep performance scores associated with the measured brain activity. The sleep performance systems can recommend and/or activate sleep improvement programs based on various threshold scores.