Systems and methods for treating biologic fluids are disclosed. Some disclosed embodiments may be used to filter cerebrospinal fluid (CSF) from a human or animal subject, heat CSF to a target temperature, cool CSF to a target temperature, apply light treatment to CSF, separate cells via their dielectric properties, apply spiral and/or centrifugal separation, introduce additives to target particles, and/or apply combinations thereof. The method may include the steps of withdrawing fluid comprising CSF, treating the fluid, and returning a portion of the treated fluid to the subject. During operation of the system, various parameters may be modified, such as flow rate.

Systems and methods for performing apheresis procedures, including photopheresis, are disclosed. The systems and methods utilize a disposable fluid circuit that can be converted from a double needle configuration to a single needle configuration and from a single needle configuration to a double needle configuration. A controller directs the action of system pumps to clear potentially stagnant blood residing in the fluid circuit, tracks system parameters and status before and after conversion, and verifies that the procedure may proceed in its new configuration.

The invention comprises an indwelling medical device which is capable of delivering a therapeutic agent evenly along the length of the indwelling portion, including the outer wall, of the device.

The present disclosure relates to a hemodialysis catheter that can monitor intravascular pressure using a MEMS sensor. The hemodialysis catheter comprises a venous lumen, an atrial lumen, and at least one MEMS system sensor. The hemodialysis catheter also comprises a data acquisition and processing system. The hemodialysis catheter can communicate with a monitor system to display pressure data.

A catheter comprising an elongated body (12) defining one or more lumens (40,42), and the elongated body comprises a sidewall defining a side opening (14) in fluid communication with a lumen of the one or more lumens. The side opening has a proximal end (14A), a distal end (14B), a first side (34) extending from the proximal end to the distal end, and a second side (36) opposing the first side and extending from the proximal end to the distal end. When the elongated body is straight, the first and second sides curve towards each other between the proximal and distal ends, e.g., to define a biconcave shape.

A cannula apparatus (100) and method are provided for selective fluid flow in removal and return directions. An outer sheath (102) has proximal (104) and distal (106) outer sheath ends spaced apart by a longitudinal outer sheath body (108) defining an outer sheath lumen (110). At least one fluid removal aperture (112) extends through the outer sheath body. The outer sheath includes a side access aperture (114). An introducer (1534) has proximal (1536) and distal (1538) introducer ends spaced apart by a longitudinal introducer body (1540), which at least partially defines a guidewire channel (1542) longitudinally therealong. The introducer is configured for insertion into the outer sheath lumen with the guidewire channel in fluid communication with the side access aperture. An inner tube (218) has proximal (220) and distal (222) inner tube ends. At least one fluid return aperture (228) is located at least one of at and adjacent the distal inner tube end to place an inner tube lumen in fluid communication with an ambient space.

A catheter stabilizer and a method for installing the stabilizer are especially suited to retaining a catheter in its position of insertion into the body of a patient. The stabilizer is a laminate of clear film atop double-backed adhesive preferably atop peel-off release paper. The double-backed adhesive defines a viewing window through the stabilizer. The stabilizer and method reduce preparation-of-materials steps, eliminate performance of arbitrary, awkward or inconsistently-performable installation steps, result in predictably effective catheter-to-patient connections, mitigate against the likelihoods of migration of the catheter out of the incision or expansion of the length of the incision during and after installation, create a sterile environment to the area surrounding the point of penetration of the catheter into the anatomy, extend the effective life of the installation, reduce the risks of complications and costs associated with replacement of a catheter and enable a rapid and sound installation.

A catheter includes: a body comprising a body side wall, a proximal end and a distal end; a septum extending from the proximal end to the distal end; a first lumen and a second lumen separated by the septum, each lumen forming a mouth at the distal end; first and second slots formed in a portion of the body side wall at the distal end and in fluid communication with the first and second lumens respectively. The first and second slots extend linearly along a direction parallel to a longitudinal axis of the body. The distal end of the body and the septum terminate in a plane perpendicular to the longitudinal axis. The distal end of the body has a substantially round cross section, while the first and second lumens each have a substantially D-shaped cross-section at the distal end. The two slots each have a width that is between 30% and 60% of a longer dimension of the D-shaped cross-section of a corresponding lumen.

Methods, devices, systems of resuscitating a patient including accessing an arterial vessel positioning a catheter into the arterial vessel advancing the catheter through the arterial vessel to position it below a vessel supplying blood to a heart and a brain expanding an expandable portion of the catheter to prevent blood from flowing past the expanded portion and infusing a substance retrograde into the artery within the arterial section between the heart and the expanded portion of the catheter.

A device for perfusing a coronary sinus of a subject's heart which may include: a double-lumen catheter including: a first lumen having: a proximal opening, and a distal opening configured to be positioned in a coronary sinus of a subject's heart; and a second lumen parallel to the first lumen, the second lumen having: a proximal opening, and a distal opening being offset from the distal opening of the first lumen towards the proximal opening of the second lumen in a longitudinal direction, the distal opening of the second lumen being configured to be positioned in a right atrium of the subject's heart; and an oxygenator connected to the proximal openings of the first lumen and the second lumen, the oxygenator is configured to oxygenate deoxygenated blood.