A clot removal system for removing a clot from a body vessel, the clot removal system including: a microcatheter including: a distal segment comprising a first diameter; and a proximal segment comprising a second diameter; a stentriever positionable substantially within a lumen of a distal end of the microcatheter, the stentriever including: an engagement structure configured to expand when distal of the microcatheter in an expanded configuration, and an elongated member proximal of the engagement structure and extending to a proximal end of the microcatheter; and a hand control disposed on the proximal end of the microcatheter for controlling extending and retracting the engagement structure from the microcatheter.

A microcatheter comprising an inner layer, a strike layer and an outer layer and a braided skeleton located between the inner layer and the outer layer, wherein the inner layer is made of Polytetrafluoroethylene (PTFE) and has a thickness of 0.0015 inch or less, wherein the strike layer includes a polyether block amide and has a thickness of 0.001 inch or less, and wherein a distal portion of said outer layer is made of polycarbonate-based thermoplastic polyurethane having a shore of 90A or below.

Antifibrinolytic agents/drugs are applied to the concussive area of a patient's brain to counter the activation of a fibrinolytic process in the concussive area. Various techniques are described for administering the antifibrinolytic agent.

An illustrative drug delivery system implantable in a recipient may include a connection assembly, a source catheter, and a microcatheter. A proximal end portion of the source catheter may be configured to be fluidically connected to a fluid source configured to provide a fluid (e.g., a neurotherapeutic drug). A distal end portion of the source catheter may be configured to be fluidically connected to the connection assembly. The microcatheter may include a proximal end portion configured to be fluidically connected to the connection assembly and a distal end portion comprising an elution opening configured to elute the fluid to a target location (e.g., a brain) within a recipient. The fluid source may be configured to provide the fluid to the target location by way of the source catheter, the connection assembly, and the microcatheter.

Apparatus and methods are described herein for a secondary valve apparatus that can be deployed within an existing implanted prosthetic heart valve. In some embodiments, a secondary prosthetic heart valve apparatus is implanted in series with an existing deteriorating implanted prosthetic valve. The secondary valve apparatus can restore proper valve function without disruption to the failing previously implanted valve. In some embodiments, the secondary valve apparatus can be positioned on an atrial portion of the existing valve, and be delivered transseptally. In other embodiments, the secondary valve apparatus can be positioned at a ventricular portion of the existing valve and delivered transapically. Devices and methods to prepare the existing valve to receive a secondary valve apparatus are also described herein. In some embodiments, a balloon expansion device can be used to expand an inner diameter of the existing valve to provide space for the secondary valve to be disposed.

There is provided a microcatheter having a proximal solution lumen and a distal tip portion with a guidewire lumen. The microcatheter and methods of use thereof allows for introduction of solution into a vessel while manipulating the guidewire and/or the microcatheter itself. The solution may be a contrast solution, for viewing of the vessel, a therapeutic or diagnostic solution, or any other type of solution.

An intracranial intervention system comprises a seeker wire and delivery catheter used to navigate and access a target location within the intracranial subarachnoid spaces (ISAS) of a patient. A microcatheter is then advanced through the delivery catheter to perform a therapeutic procedure, such as installing a shunt within the ISAS to drain cerebral-spinal fluid (CSF). The shunt may be configured to drain CSF from a first and second ISAS, and includes a distal portion which extends into the first ISAS via the second ISAS and a dural venus sinus (DVS) of the patient. The shunt has a main body portion positioned and secured within the second ISAS, a distal portion extending into the first ISAS and the main body portion in the second ISAS have CSF intake opening which allow CSF to flow into a shunt lumen and out through an outflow opening positioned in the DVS.

Medical delivery devices, such as catheters, and their methods of use and manufacture. The medical delivery devices are adapted to facilitate the delivery of an agent into a patient. The medical delivery devices may have one or more deformable lumens, each of which has a collapsed configuration and an open configuration. The medical delivery devices may include one or more agent delivery ports, any one of which may be proximal or distal to an expandable device, such as a balloon.

Devices and methods are disclosed for the treatment or repair of regurgitant cardiac valves, such as a mitral valve. An annuloplasty device can be placed in the coronary sinus to reshape the mitral valve and reduce mitral valve regurgitation. A protective device can be placed between the annuloplasty device and an underlying coronary artery to inhibit compression of the underlying coronary artery by the annuloplasty device in the coronary sinus. In addition, the protective device can inhibit compression of the coronary artery from inside the heart, such as from a prosthetic mitral valve that exerts radially outward pressure toward the coronary artery. The annuloplasty device can also create an artificial inner ridge or retaining feature projecting into the native mitral valve region to help secure a prosthetic mitral valve.

An aortic perfusion catheter is an apparatus that is used during surgery for acute ascending aortic dissection to reduce postoperative injuries from profound hypothermia, ischemia, and reperfusion. The apparatus may include at least one main cannula, an inflation cannula, a drainage cannula, and a balloon tamponade. The at least one main cannula helps maintain blood perfusion to the body during the procedure to reduce postoperative injuries. The inflation cannula enables the selective inflation and deflation of the balloon tamponade to facilitate the insertion and removal of the balloon tamponade along with the at least one main cannula within the descending thoracic aorta. The balloon tamponade prevents blood flow into the operative area to maintain the operative area clear during the procedure. The drainage cannula enables the drainage of blood that may escape the balloon tamponade as well as other bodily fluids.