Various exemplary methods and devices (10, 110, 210) for delivering liquid therapeutic agents in solid tumors are provided. In general, a delivery device configured to deliver a liquid therapeutic agent into a solid tumor or other soft tissue can be configured to compress tissue and seal any fluid gaps around the delivery device during the delivery of the liquid therapeutic agent. In an exemplary embodiment the delivery device includes three elongate tubular shafts (12, 14, 16, 112, 114, 116, 212, 214, 216) configured to move longitudinally relative to one another. The elongate tubular shafts are configured to cooperate with one another to deliver the liquid therapeutic agent through a passageway of the delivery device to the solid tumor or other soft tissue and seal any fluid gaps around the delivery device while the liquid therapeutic agent is delivered into the solid tumor or other soft tissue.

An intracranial intervention system comprises a seeker wire and delivery catheter used to navigate and access a target location within the intracranial subarachnoid spaces (ISAS) of a patient. A microcatheter is then advanced through the delivery catheter to perform a therapeutic procedure, such as installing a shunt within the ISAS to drain cerebral-spinal fluid (CSF). The shunt may be configured to drain CSF from a first and second ISAS, and includes a distal portion which extends into the first ISAS via the second ISAS and a dural venus sinus (DVS) of the patient. The shunt has a main body portion positioned and secured within the second ISAS, a distal portion extending into the first ISAS and the main body portion in the second ISAS have CSF intake opening which allow CSF to flow into a shunt lumen and out through an outflow opening positioned in the DVS.

Methods and devices for trans-jugular carotid access are disclosed. Methods within the scope of this disclosure include methods of trans-jugular carotid access originating in the leg of a patient or other location remote to the jugular vein and carotid artery and methods originating at the neck of a patient. Devices used in connection with the disclosed methods may comprise access catheters, lumens, and stylets.

Methods and devices for trans-jugular carotid access are disclosed. Methods within the scope of this disclosure include methods of trans-jugular carotid access originating in the leg of a patient or other location remote to the jugular vein and carotid artery and methods originating at the neck of a patient. Devices used in connection with the disclosed methods may comprise access catheters, lumens, and stylets.

A probe for real-time sensing of a target biomarker the includes a needle, a luminescent probe within the opening of the needle, a coating comprising a biomarker luminescent material in contact with biological tissue, and an ion-consuming coating within the needle and adjacent to the coating. The disclosed probe is useful for real-time sensing of blood during medical procedures. Additionally, a biomarker detection system is disclosed that includes a biomarker luminescent material at the tip of or inside of the tip of a needle and an optical coupler.

A catheter extension set may include a housing, which may include a distal end, a proximal end, and a lumen. The catheter extension set may include a distal connector coupled to the distal end of the housing and configured to couple to a catheter assembly. The catheter extension set may include a handle, an advancement element, and an instrument. The instrument may extend through a U-shaped channel of the advancement element and may include a fixed first end and a second end. A translation feature may be disposed between the handle and the housing and within a pocket of the advancement element such that in response to distal movement of the handle a first distance, the advancement element moves distally within the lumen the first distance and the second end of the instrument advances distally a second distance. The second distance may be at least twice the first distance.

A method of making a catheter includes obtaining a hollow tube having a proximal section, a distal section, an elongated conduit, and one or more fluid openings formed in the distal section of the hollow tube that are in fluid communication with the elongated lumen. The method includes inserting a mandrel within the elongated lumen, positioning a first visible marker over an outer surface of the hollow tube at a junction of the proximal and distal sections of the hollow tube, and placing a sacrificial material over the first visible marker to completely cover the first visible marker. Heat is applied for shrinking the sacrificial material, which, in turn, compresses the first visible marker against the outer surface of the hollow tube, and for least partially melting the first visible marker for fusing the first visible marker to the outer surface of the hollow tube.

Methods, devices, and kits for implanting a vascular graft to perform hemodialysis treatments on patients with renal failure are disclosed. The kits can include access devices comprised of an access catheter having a guidewire lumen and stylet lumen, a guide tube having a curved distal end, a stylet, an actuator handle and a vascular graft. The methods describe techniques for using the described kits and devices for performing vascular procedures, such as percutaneous implantation of the vascular graft.

An endoluminal punch and introducer sheath are described wherein the endoluminal punch comprises a guidewire lumen through which a user is capable of placing a guidewire. The endoluminal punch system further comprises a mechanism affixed to the hub which is capable of controlling the axial positioning of the guidewire relative to the endoluminal punch distal end. The control mechanism can be released so that the endoluminal punch can be removed from a patient while retaining the guidewire in place within the patient. The endoluminal punch introducer, including a sheath and dilator, can comprise energy emitting electrodes or transducers for cutting larger size holes in stubborn (friable, scarred, or fibrotic) tissue. In other embodiments, the endoluminal punch can comprise a guidewire or stylet, wherein the guidewire or stylet is capable of emitting energy to cut through tissue.

Systems, devices, and methods are provided for transseptal access of septa within a patient. The device can be advanced to a septum, e.g., towards a fossa ovalis. Instead of applying positive pressure to “tent” the septum, a negative pressure is applied to a lumen within a sheath, e.g., within an elongated member slidable within the sheath, via a negative pressure source such as a syringe on the proximal end of the sheath. This results in the septum pulling inward. The sheath employs a stationary needle-like central core component contained within the lumen of the sheath that punctures the septum when the same is pulled passed it by the negative pressure. The stationary needle-like central core component may be hollow and may form a portion of the elongated member or may be coupled to a distal end thereof.