Medical devices including balloons and balloons are provided that include an elongate body and an inflatable balloon defining a longitudinal axis, the inflatable balloon being attached to and partially surrounding at least a section of the elongate body. The medical device further includes a plurality of protrusions extending from the inflatable balloon. When the inflatable balloon is in an unstrained state, each of the plurality of protrusions extends in a first transverse direction relative to the longitudinal axis. In certain implementations, the inflatable balloon may also be configured to collapse such that, when in a collapsed state, an untextured portion of the inflatable balloon extends to a radius and the plurality of protrusions does not extend beyond the radius.

An ostial stent delivery device may include a first elongate shaft including a first lumen and extending along a central longitudinal axis, wherein the first elongate shaft includes a first inflatable balloon fixedly attached proximate a distal end of the first elongate shaft; and a second elongate shaft including a second lumen, the first elongate shaft being at least partially disposed within the second lumen. The second elongate shaft includes a second inflatable balloon fixedly attached proximate a distal end of the second elongate shaft. The second inflatable balloon is disposed at least partially proximal of the first inflatable balloon. The first inflatable balloon has a substantially cylindrical shape along a majority of its length in the deployed configuration. The second inflatable balloon has a substantially biconical shape having a central axis oriented parallel to the central longitudinal axis in the deployed configuration.

A multi-stage balloon catheter has a deflated state, a first inflation state at a first pressure and a second inflation state at a higher fluid pressure. In the first inflation state, the multi-stage balloon has a plurality of bulb segments separated by waist hoops that allow the multi-stage balloon to conform to match the curvature of a passageway. When pressure is increased in the multi-stage balloon from the first inflation state to the second inflation state, the waist locations expand either by breaking or stretching the waist restraints or by overcoming expansion resistance incorporated into the balloon material at the waist locations. The multi-stage balloon catheter may be used to implant a stent in a manner to conform and match a curved passageway rather than tending to straighten the passageway.

Disclosed herein is a method of producing high purity pentagalloyl glucose (PGG), analogues or derivatives thereof, at least 99.9% pure, by washing with dimethyl ether. PGG may be provided in a kit, including a hydrolyzer for dissolving the PGG and a saline solution. Also disclosed herein is a device for delivery of a therapeutic solution to a blood vessel. The device may be a catheter having an upstream balloon and a downstream balloon. The upstream balloon may be expanded to anchor the catheter and occlude antegrade blood flow. The downstream balloon may be expanded to occlude retrograde blood flow, creating a sealed volume within the blood vessel. The downstream balloon may have pores configured to deliver a therapeutic inflation solution into the sealed volume or a portion thereof. The downstream balloon may be expanded by the expansion of a balloon disposed inside the downstream balloon.

A dilation catheter includes a shaft, a distal tip sized and configured to pass through an isthmus of a Eustachian tube (ET), and an expandable element moveable along an exterior of the shaft between a proximal position and a distal position. The expandable element is operable to transition between an unexpanded state in which the expandable element is configured for insertion into the ET via the isthmus, and an expanded state in which the expandable element is configured to dilate the ET.

A device is disclosed for occluding an anatomical passage between first and second anatomical structures. The device includes a tip portion having a proximal element connected to a distal element through a member. The proximal element and/or distal element is movable axially along the tip portion while the other element preferably remains fixed in place. A handle is coupled to a proximal end of the tip portion through a shaft. The tip portion is positioned across the anatomical passage so that the proximal element occludes a first side of the passage and the distal element occludes a second side of the passage. A locking structure, such as a nut, is positioned or crimped against the proximal element, and, once done, the tip portion is released at the occluded passage.

A double-balloon catheter device for gastrointestinal anastomosis. The double-balloon catheter device for gastrointestinal anastomosis includes a liquid injection assembly, a double-balloon assembly, and a supporting device (15) connecting the liquid injection assembly and the double-balloon assembly. The liquid injection assembly includes a first balloon liquid injection connection port (2), a guide wire connection port (3), and a second balloon liquid injection connection port (4). The double-balloon assembly includes a double-balloon catheter device (5), and includes a first balloon (6) and a second balloon (7) that can expand-and that are respectively disposed on the two ends of the double-balloon catheter device (5). The double-balloon catheter device (5) is provided with a first balloon liquid injection channel (51), a guide wire channel (52), and a second balloon liquid injection channel (53).

A urinary catheter may include a catheter shaft and a connector coupled with the proximal end of the catheter shaft. The connector may have a first arm ending in a fluid outlet configured to allow urine to flow out of the urinary catheter and a second arm with an aperture and ending in an inflation inlet used for introducing inflation fluid into the urinary catheter. The catheter may further include a primary lumen, an inflation lumen, a retention balloon mounted to the catheter shaft proximal to a fluid inlet and over a distal filling hole, and a pilot balloon mounted on the second arm of the connector over the aperture. The pilot balloon inflates at an inflation pressure that is higher than the inflation pressure of the retention balloon and lower than a predetermined pressure threshold.

In various embodiments, the present specification discloses an aspiration catheter that has a slim profile, can effectively anchor or self-center in a location, within a patient's vessel lumen, to better provide directed suction or vacuum/negative pressure, and/or can effectively funnel or direct suction or vacuum/negative pressure toward an occlusion or obstruction within the patient's vessel lumen.

Disclosed is an inter- and intra-catheter flow device for the management of vascular bleeding disorders that provide a liquid flow-pass between proximal and distal balloons for bridging the circulation between the upper and lower segments of a hemorrhaging artery or blood vessel, while blocking the blood flow to the hemorrhaging middle segment(s) of the artery or blood vessel between the two or more balloons. When only one balloon is inflated, these devices can create a pressure gradient between proximal or distal and middle segments of the artery or blood vessel. These devices are useful for controlling proximal artery blood pressure, preventing distal ischemia-reperfusion injury, identifying the bleeding location, controlling the bleeding, repairing and remodeling vascular structures, extending resuscitative endovascular balloon occlusion of the aorta (REBOA) use duration, and performing fluid resuscitation.