A61M2025/1088

DRUG-LOADED IMPLANTABLE MEDICAL INSTRUMENT AND MANUFACTURING METHOD THEREFOR
20230044992 · 2023-02-09 ·

Provided are a drug-loaded implantable medical instrument and a manufacturing method therefor. The drug-loaded implantable medical instrument (10) comprises an instrument body (100), a microporous membrane (200) fixed on the instrument body (100), and a nanocrystal medicament (300) loaded on the microporous membrane (200). A method for preparing a drug-loaded implantable medical device includes: providing a microporous membrane; loading a nanocrystalline drug on the microporous membrane; and fixing the microporous membrane loaded with the nanocrystalline drug to the device body.

THROMBECTOMY AND ASPIRATION SYSTEM AND METHODS OF USE
20230233818 · 2023-07-27 ·

Devices, systems, and methods for performing thrombectomy procedures are disclosed herein. The devices can include an aspiration catheter which optionally has a beveled distal end. The aspiration catheter is advanced to a position adjacent a thrombus. A blocking element can be expanded near the distal end of the aspiration catheter to block fluid flow during the procedure. The devices can include a thrombus retrieval device supporting a braided assembly that grips and facilitates removal of the thrombus. The braided assembly is expandable to a range of expanded outer diameters by varying the level of tension in an activation wire attached thereto. An expander can be deployed beneath the braided assembly to exert an outward expansion force upon the braid, thereby increasing the grip between the braided assembly and the thrombus. The braided assembly contacts the thrombus and the retrieval device pulls it proximally toward the aspiration catheter.

Inflatable medical devices

Inflatable medical devices and methods for making and using the same are disclosed. The inflatable medical devices can be medical balloons. The balloons can be configured to have a through-lumen or no through-lumen and a wide variety of geometries. The device can have a high-strength, non-compliant, fiber-reinforced, multi-layered wall. The inflatable medical device can be used for angioplasty, kyphoplasty, percutaneous aortic valve replacement, or other procedures described herein.

Conformable balloon devices and methods

The present disclosure is directed toward a semi-compliant to non-compliant, conformable balloon useful in medical applications. Conformable balloons of the present disclosure exhibit a low straightening force when in a curved configuration and at inflation pressures greater than 4 atm. Balloons of the present disclosure are constructed of material that can compress along an inner length when the balloon is in a curved configuration. In further embodiments, balloons of the present disclosure can be constructed of material that sufficiently elongates along an outer arc when the balloon is in a curved configuration. As a result, medical balloons, in accordance with the present disclosure, when inflated in a curved configuration, exhibit kink-free configurations and do not cause a significant degree of vessel straightening.

Catheter for ultrasound-guided delivery

A catheter including one or more echogenic members facilitate guiding the catheter to a selected locations within a patient using ultrasound imaging. The echogenic members may include expandable members, such as balloons, be positioned near a distal end of the catheter. The echogenic members include an echogenic material, such as a coating or a fluid, that is configured to enhance the diffuse sound scattering of the echogenic member. An expanded echogenic member is detectable using ultrasound imaging.

Microminiature patterned metal on medical grade balloons

A thin walled balloon formed in polymer tubing has a patterned metal layer on its outer surface, created by physical vapor deposition (PVD). The pattern is defined by a stencil mask assembled around the balloon, with the balloon inflated therein. The PVD occurs without deforming or degrading the polymer material of the balloon, by actively pulling heat away from the balloon a) by forming the stencil mask out of metal; b) by providing a metal heat conduction path away from the balloon to a heat sink, such as outside the vacuum chamber, and/or c) by flow of a cooling fluid within the balloon during the PVD process. Proper PVD process parameters are selected to minimize heat generation, such as having argon pressure in the range of 0.8 to 1.2 milli-torr and generating the plasma at a power of less than about 200 watts/ square inch of effective target surface area.

Apparatus and methods to create and maintain an intra-atrial pressure relief opening

The present disclosure relates to a method and a device for treating heart failure by normalizing elevated blood pressure in the left and right atria of a heart of a mammal. The present disclosure includes methods for creating and maintaining an opening in the atrial septum. Tools for making an opening and enlarging the opening are also disclosed. Use of the techniques and tools described herein prolongs the patency of an intra-atrial pressure relief opening.

Weeping balloon devices

Catheters with weeping balloons can be used for various medical purposes. For example, in some embodiments provided herein weeping balloons are used for catheter visualization devices. In some embodiments, weeping balloons are used to deliver therapeutic agents. Weeping balloons can include openings of a selected size and shape through which a fluid gradually flows or “weeps.” The design of the openings can affect performance characteristics such as, but not limited to, fluid flow rate, tear resistance, and mitigation of counter-flow.

Balloon catheter with transient radiopaque marking

Treating a treatment area in the vasculature includes a first catheter adapted for positioning at the treatment area, said first catheter including a first balloon having a transient radiopaque material corresponding to the treatment area. A second catheter adapted for positioning at a treatment area includes a treatment that substantially matches the transient radiopaque material, preferably so that the length and/or position of the treatment corresponds to the length and/or position of the transient radiopaque material. Related kits, assemblies, and methods are also described.

Balloon catheter with non-deployable stent
11571554 · 2023-02-07 · ·

An angioplasty balloon including a non-deployable stent to prevent or reduce the potential for slippage of the inflated balloon with respect to the vessel wall being treated. The balloon includes a non-deployable stent that is adapted to be secured to the balloon or angioplasty balloon catheter. The stent has a proximal end, a distal end, and at least three radially-spaced struts, each, each strut connecting the proximal end to the distal end and having one or more bends that allow expansion of the strut to accommodate the inflation of the balloon. The stem is made or a material so that the stent collapses upon deflation of the balloon.