A tubular shaped elongated catheter device assembly with a distal and a proximal end, comprising an intraluminal distal segment and an extraluminal proximal segment, comprising one or more chemical and/or biological agents, for interaction with bodily fluids of luminal organs, wherein the intraluminal segment comprises at least one expandable cross-sectional area which in its expanded state is smaller than the cross-sectional area of the luminal target site and wherein at least the expandable portion of the intraluminal segment is capable of interacting with at least one component of the bodily fluid via an interactive contact surface.

Inflatable medical devices and methods for making and using the same are disclosed. The devices can be medical invasive balloons, such as those used for transcutaneous heart valve implantation, such as balloons used for transcatheter aortic-valve implantation. The balloons can have high strength, fiber-reinforced walls.

Systems (1100) for treating a blood flow passage are discloses herein. In one example, a treatment device includes an expandable element (1104) configured to be positioned within the passage and a reinforcing element (1102). The expandable element may have an expanded configuration in which the expandable element defines a lumen (1108) therethrough. The reinforcing element may be positioned within the lumen of the expandable element. The reinforcing element may be coupled to the expandable element such that expansion of the expandable element causes the reinforcing element to radially expand, thereby creating a perfusion lumen through the device.

An apparatus for performing a medical procedure and, in particular, an aortic valvuloplasty, in a vessel for transmitting a flow of fluid. The apparatus comprises a shaft, an inflatable perfusion balloon supported by the shaft and including an internal passage for permitting the fluid flow in the vessel while the perfusion balloon is in an inflated condition, and a valve for controlling the fluid flow within the passage. The valve may be connected to the shaft, or may comprise an elongated tube partially connected to the balloon. The balloon may comprise a plurality of cells in a single cross-section, each cell including a neck, and the valve may be positioned in a space between the shaft and the necks for controlling the fluid flow within the passage. A connector may also be provided to control the position of the valve.

Inflatable medical devices and methods for making and using the same are disclosed. The inflatable medical devices can be medical balloons. The balloons can be configured to have a through-lumen or no through-lumen and a wide variety of geometries. The device can have a high-strength, non-compliant, fiber-reinforced, multi-layered wall. The inflatable medical device can be used for angioplasty, kyphoplasty, percutaneous aortic valve replacement, or other procedures described herein.

A method of inducing retrograde blood flow may include extending a sheath through opposite walls of one of an artery and a vein of a subject and through a wall of the other of the artery and the vein such that a distal end of the sheath may be positioned within one of the artery and the vein. The method may include inducing retrograde blood flow in the artery and delivering the induced retrograde blood flow into the vein of the subject via the sheath.

An hourglass shaped three-chambered and tunneled balloon catheter suitable for use in the placement of an aortic valve during the transcatheter aortic valve implantation (TAVI) process.

The present disclosure provides a catheter assembly including a catheter tube and an expandable unit attached to the catheter tube. The expandable unit is configurable in a collapsed configuration for facilitating delivery of the catheter assembly through a body lumen and a fully expanded configuration for contacting an interior wall of the body lumen to cover a perforation. The expandable unit defines a longitudinal channel extending from a proximal end to a distal end of the expandable unit when in the fully expanded configuration, permitting blood flow past the expandable unit. The disclosure further provides a method of treating a perforation by delivering a catheter assembly with an expandable unit to a perforation site, expanding the expandable unit to contact an interior wall of a body lumen to cover the perforation, and permitting blood flow past the expandable unit while in contact with the interior wall covering the perforation.

An apparatus for performing a medical procedure and, in particular, an aortic valvuloplasty, in a vessel for transmitting a flow of fluid. The apparatus includes an inflatable perfusion balloon including an internal passage for permitting the fluid flow in the vessel while the perfusion balloon is in an inflated condition, the balloon including a plurality of cells in a single cross section and a covering for at least partially covering the cells. A valve associated with the balloon controls the fluid flow within the passage, the valve being arranged external to the passage. The valve may form a tubular extension of the covering, or may be separate from the covering, and may comprise flaps. A spiral covering may also form the valve.

This patent document discloses perfusion catheters and related methods for treating blood vessel lesions and abnormalities. A perfusion catheter can include an inflatable balloon, an elongate shaft operably attached to the balloon, and an optional containment structure surrounding at least a portion of the balloon. The balloon can be inflated until its outer surface contacts a wall of a blood vessel. When inflated, the balloon's inner surface defines a passage for blood to flow. The balloon can be configured to release one or more substances formulated to treat a tissue at or near the wall of a blood vessel. In an example, the balloon can include a bioactive layer, which comprises the one or more substances, overlaying an optional base layer. In an example, the balloon can include multiple filars, at least one of which is configured to elute the one or more substances through a perforation or hole in the filar.