A needle-free connector assembly is provided that includes a main housing coupled to an indicator housing. A plunger is coupled to a bellows disposed in the main housing. An inlet port is disposed at an upstream end of the indicator housing and an outlet port is disposed at a downstream end of the main housing, with a valve disposed within the indicator housing and adjacent the inlet port. A switch member is slidingly disposed in the main housing, wherein the needle-free connector assembly provides both flow regulation and pressure indication when the switch member is in a downstream position and only pressure indication when the switch member is in an upstream position. Infusion sets and methods of operating a needle-free connector are also provided.

A system for modulating delivery of a fluid medium includes an injector for injecting the fluid medium during an injection cycle, a delivery catheter including a conduit for delivering the fluid medium, a manifold disposed in a fluid medium flow path between the injector and the delivery catheter, and a pulsatile generator. The pulsatile generator is configured to apply a pulsatile force to the fluid medium defined by a plurality of duty cycles during the injection cycle, each of the duty cycles including a first pressure level and a second pressure level that is lower than the first pressure level.

A connector for connecting a container containing a medical fluid to a vascular access device may include an upper housing defining a first internal chamber, and a lower housing coupled to the upper housing and defining a second internal chamber for circulation of the medical fluid into the outlet. The connector may further include a slider disposed at least partially in the first and second internal chambers, and a plug coupled to a distal end of the slider. The slider may be reciprocally movable between (i) an open position, where the plug is spaced apart from a floor of the internal chamber to allow the medical fluid to flow through the outlet, and (ii) a closed position where the plug abuts the floor of the second internal chamber to block the medical fluid from flowing through the outlet.

An airway assist device and methods of making and using an airway assist device to assist in opening an airway or removing fluid or material obstructing an airway of a subject.

Devices, systems and methods for controlling, regulating, altering, transforming or otherwise modulating the delivery of a substance to a delivery site. The devices, systems and methods optimize the delivery of the substance to an intended site, such as a vessel, vascular bed, organ and/or other corporeal structures, while reducing inadvertent introduction or reflux substance to other vessels, vascular beds, organs, and/or other structures, including systemic introduction.

Devices, systems and methods for controlling, regulating, altering, transforming or otherwise modulating the delivery of a substance to a delivery site. The devices, systems and methods optimize the delivery of the substance to an intended site, such as a vessel, vascular bed, organ and/or other corporeal structures, while reducing inadvertent introduction or reflux substance to other vessels, vascular beds, organs, and/or other structures, including systemic introduction.

A sphygmomanometer device includes a piezoelectric pump, a valve, and a cuff. The valve includes a first valve housing, a diaphragm, and a second valve housing. The diaphragm is fixed to the second valve housing and first valve housing such that it is separated from a valve seat and the periphery of an opening portion in the diaphragm is in contact with a valve seat while providing a pressure thereto. Thus, the diaphragm defines a lower valve chamber communicating with a first vent hole, an upper valve chamber communicating with a second vent hole, a lower valve chamber communicating with a first vent hole, and an upper valve chamber communicating with the upper valve chamber, together with the second valve housing and first valve housing.

Systems and methods are described for implementing or deploying one or more capture components configured to accelerate a decrease in a local concentration of one or more therapeutic structures along a downstream portion of a vasculature and one or more dispensation components configured to release the one or more therapeutic structures into an upstream portion of the vasculature.

A device for managing fluid is provided. The device includes: a drip chamber including: an inlet; and outlet; a check valve positioned between the inlet and the outlet, the check valve configured for managing fluid flowing between the inlet and the outlet; and an elastic element. The combination of the check valve and the elastic element limits the extent to which the one way valve may be opened by brief transient pressures appearing at the outlet of the drip chamber. This limiting effect improves the accuracy of fluid delivery in setups such as ‘piggyback’ or Secondary Mode infusions of two fluids using a single pump.

A pressure relief valve for a reservoir has a main body with a central chamber defining an outer radial seat, a positive-pressure port with an inner radial seat, and a negative-pressure port comprising an internal passage spanning the outer seat. The sealing disk has an anchor body retained in the central chamber and a flexible diaphragm biased against the outer seat. An axial passage in the anchor body couples the central chamber to ambient atmospheric pressure. The sealing ball is biased against the inner seat. When a pressure inside the reservoir exceeds ambient by a positive-pressure threshold, then the sealing ball lifts off the inner radial seat to exhaust a gas through the positive-pressure port. When the pressure inside the reservoir is below ambient by a negative-pressure threshold, then the diaphragm is lifted off the outer seat to intake atmospheric gas into the reservoir.