The invention relates to a patient interface comprising a plenum chamber, a seal-forming structure, and a positioning and stabilizing structure, as well as the method of operating the patient interface. The patient's interface is configured to leave a patient's mouth uncovered or if the seal-forming structure is configured to seal around a patient's nose and mouth, the patient interface is configured to allow the patient to breath from the ambient in an absence of the flow of pressurized. The positioning and stabilizing structure includes headgear, and the seal-forming structure and at least a portion of the headgear is formed from a one piece construction of textile material. In another embodiment, the seal-forming structure and/or the positioning and stabilizing structure includes an adaptive portion that adjusts based on usage conditions. In another embodiment, the positioning and stabilizing structure, the seal-forming structure and/or the plenum chamber includes and/or is formed of a textile material, and the textile material includes at least one magnetic thread constructed of magnetic material to provide a magnetic interaction between a first part of the patient interface and a second part of the patient interface. In another embodiment, a stiffener is coupled to the plenum chamber, the seal-forming structure, and/or the positioning and stabilizing structure. In another embodiment, at least one of the plenum chamber and the seal-forming structure includes a textile material; and wherein the textile material includes a surface structure that limits adhesion of debris. A UV cleaning receptacle of the patient interface is also disclosed.

Disclosed herein are apparatuses and methods for a user-wearable infusion pump actuated with a shape memory alloy (SMA) wire. Embodiments enable an SMA wire driven infusion pump using a single length of SMA wire to provide multiple pulse sizes and corresponding medicament dispensing sizes. The multiple pulse sizes can include a larger pulse size for larger volumes to limit battery drain but smaller pulse sizes for precision of delivery.

Drug delivery articles, resident articles, and retrieval systems e.g., for gram-level dosing, are generally provided. In some embodiments, the articles are configured for transesophageal administration, transesophageal retrieval, and/or gastric retention to/in a subject. In certain embodiments, the article includes dimensions configured for transesophageal administration with a gastric resident system. In some cases, the article may be configured to control drug release e.g., with zero-order drug kinetics with no potential for burst release for weeks to months. In some embodiments, the articles described herein comprise biocompatible materials and/or are safe for gastric retention. In certain embodiments, the article includes dimensions configured for transesophageal retrieval. In some cases, the articles described herein may comprise relatively large doses of drug (e.g., greater than or equal to 1 gram).

An adhesive convertible tissue stabilizer is provided which can be applied preoperatively to a patient to retract tissue to facilitate a medical/surgical procedure. As a perioperative device, the convertible device accepts most, if not all, surgical preparations, enabling the creation of a sterile field. At the completion of the procedure, the convertible device is converted from a perioperative device to a post-operative device by removal of a layer of the convertible device.

A wearable infusion pump assembly. The wearable infusion pump assembly includes a reservoir for receiving an infusible fluid and a fluid delivery system configured to deliver the infusible fluid from the reservoir to an external infusion set. The fluid delivery system includes a controller, a pump assembly for extracting a quantity of infusible fluid from the reservoir and providing the quantity of infusible fluid to the external infusion set, the pump assembly comprising a pump plunger, the pump plunger having distance of travel, the distance of travel having a starting position and an ending position, at least one optical sensor assembly for sensing the starting position and ending position of the pump plunger distance of travel and sending sensor output to the controller, and a first valve assembly configured to selectively isolate the pump assembly from the reservoir, wherein the controller receives the sensor output and determines the total displacement of the pump plunger.

An impeller includes a hub and a blade supported by the hub. The impeller has a stored configuration in which the blade is compressed so that its distal end moves towards the hub, and a deployed configuration in which the blade extends away from the hub. The impeller may be part of a pump for pumping fluids, such as blood, and may include a cannula having a proximal portion with a fixed diameter, and a distal portion with an expandable diameter. The impeller may reside in the expandable portion of the cannula. The cannula may have a compressed diameter which allows it to be inserted percutaneously into a patient. Once at a desired location, the expandable portion of the cannula may be expanded and the impeller expanded to the deployed configuration. A flexible drive shaft may extend through the cannula for rotationally driving the impeller within the patient.

An implantable containment apparatus for receiving and retaining a biological moiety or a therapeutic device within a tissue bed is disclosed. The device includes a shaping element to maintain the device in a generally toroidal configuration and to return the apparatus to that configuration after deformation. The apparatus can be placed in a host tissue with minimal trauma to the patient. Methods for implanting and using the apparatus are also disclosed.

Devices for transferring fluid to or from a subject include a plunger assembly coupled to or coupleable to a cannula assembly to allow target fluid to be “front-loaded” into a distal end of the cannula assembly while the stylet is withdrawn a distance to create a vacuum and define a flow channel.

A device comprises a tubular member with a longitudinal axis having a proximal end and a distal end, at least one partial cut located at, along or near the distal end of the tubular member, the at least one partial cut comprising an orientation that is angled relative to both the longitudinal axis and an axis transverse to the longitudinal axis, a pusher member positioned within an interior of the tubular member and configured to selectively advance the distal end of the tubular member longitudinally, wherein the distal end of the tubular member is configured to at least partially rotate when the pusher member is advanced relative to the tubular member so at to facilitate placement of the distal end in a particular branch of a subject's intraluminal network, wherein the distal end of the tubular member is configured to longitudinally elongate along or near an area of the at least one partial cut.

The expandable sheath and methods of use disclosed herein are used to deliver a prosthetic device through a patient's vasculature. The sheath is constructed to be expandable in the circumferential direction, while maintaining sufficient stiffness in the longitudinal direction to withstand pushing and resist kinking The sheath includes a plurality of curved arms extending outwardly from a longitudinally extending spine. The curved arms move away from the longitudinal axis of the sheath when pushed radially outwardly by a passing prosthetic device, and move back toward the longitudinal axis once the prosthetic device has passed.