A dry powder inhaler includes a powder storage element configured to hold a powdered medicament and an inlet channel receives, powdered medicament from the powder storage element that is entrained in an airflow. The inlet channel has a first diameter and defines an opening. The inhaler includes a dispersion chamber that receives the airflow and the powdered medicament from the opening. The dispersion chamber has a second diameter. The inhaler includes an actuator housed within the dispersion chamber. The actuator oscillates within the dispersion chamber when exposed to the airflow to deaggregate the powdered medicament entrained by the airflow passing through the dispersion chamber. A ratio between the first diameter and the second diameter is between about 0.40 and 0.60 such that an audible sound is produced as the actuator oscillates. The inhaler includes an outlet channel through which the airflow and powdered medicament exit the inhaler.

Exemplary dry powder inhaler devices may include a housing body having a medicine capsule recess therein, a pair of air inlets each fluidically connecting to the recess, and an outlet body coupled to the housing body. Each inlet may have a width no greater than 1.17 mm. The outlet body may have a channel fluidically connecting the recess to an opening and configured to allow a user to draw air through the opening, thereby allowing an airstream to be drawn through the air inlets, into the housing body recess where it causes the capsule to spin and eject its contents into the airstream, and through the outlet body channel and opening to deliver the substance into the user's lungs. Dry powder respirable drug blend formulations, methods of manufacturing the formulations and drug/device combinations are also provided.

A nasal prong comprising a tube configured to be partially placed in a nasal passage of a patient, the tube having a first end, a second end, and an intermediate portion, and a lumen extending therebetween. The first end having an elongated opening configured to face supero-medially within the nasal passage, wherein airflow out of the elongated opening is directed superiorly and posteriorly within the nasal cavity, above the inferior concha, around the middle concha, and towards the roof of the nose. The intermediate portion of the tube having a bend that keeps the nasal prong on a floor of the nasal passage at and/or near the outer edge of a nostril.

The invention provides an insufflation apparatus having a housing and a gas generator arranged to be, at least partially, mounted to the housing. The housing includes a gas outlet for delivering gas to a patient and a gas storage chamber arranged to store gas and deliver it to the gas outlet. The gas generator includes a cartridge mount on the housing adapted to receive a gas generating cartridge, the gas generating cartridge containing gas generating material that generates gas that is delivered to the gas storage chamber. The invention also provides alternative insufflation apparatus, a gas cartridge and a method of generating insufflation gas.

An oscillating positive expiratory pressure device includes a housing, a top cover, and an oscillating unit. The housing includes a bottom wall and a surrounding wall. The bottom wall has an inclined enclosing surface extending downwardly and terminating at an opening. The oscillating unit is swingably connected to and disposed within the housing. The oscillating unit includes a swing member, and first and second weighting pieces. The swing member includes a swing arm, and first and second swing blocks connected to the swing arm. The first weighting piece is carried on the first swing block. The second weighting piece is carried on the second swing block. The swing arm is swingable to move the second swing block to block and unblock the opening.

An aerosol generator for an aerosol dispenser is presented where, the aerosol generator has a housing having an inlet part comprising a liquid inlet configured to guide a liquid jet (L) into the housing and an air inlet configured to guide an air flow into the housing. The housing further having an outlet part having an aerosol outlet configured to guide an aerosol (C) of liquid mixed with air out of the housing. The air inlet is configured such that at least part of the air flow entering the housing through the air inlet is obstructed at a distance from the liquid jet (L) entering the housing through the liquid inlet, thereby creating a source of turbulence in the housing to interact with droplets of the liquid jet (L) to prevent coalescence of the droplets.

A spray device includes a mouthpiece that accommodates a spray nozzle unit. The spray nozzle unit is operatively connected to a liquid reservoir to receive a pressurized liquid to be sprayed. A connection between the spray nozzle unit and the liquid reservoir is effected by a flexible tube that connects at one end substantially fixedly to the mouth piece in fluid communication with the spray nozzle device. The liquid reservoir is interchangeably coupled to the opposite end of the flexible tube and, preferably, comprises a standard syringe. A spray delivery device comprises a holder for holding the syringe and has at least one manipulator member that is configured to impose an enhanced force on the plunger.

A system for aspirating thrombus and delivering an agent includes an aspiration catheter having a supply lumen having a proximal end, a distal end, and a wall, and an aspiration lumen having a proximal end, an open distal end, and an interior wall surface adjacent the open distal end, and at least one orifice at or adjacent the distal end of the supply lumen, in fluid communication with the aspiration lumen and located proximally of the open distal end of the aspiration lumen, wherein the at least one orifice is configured to create a spray pattern that is caused to impinge on the interior wall surface of the aspiration lumen such that the spray pattern upon impinging on the interior wall surface is caused to transform into at least a substantially distally-oriented flow capable of exiting the open distal end of the aspiration lumen.

Systems, devices, and methods for coupling a tracheostomy tube to a source of humidified breathing gas are disclosed. An adaptor includes a housing, a tracheostomy tube connection device, and a baffle. The housing has an interior surface, an exterior surface, and a breathing gas port. The tracheostomy tube connection device is positioned within the housing and includes an input port for receiving a flow of humidified breathing gas from the breathing gas port and an output port for coupling with the tracheostomy tube. The tracheostomy tube connection device has an internal surface defining a breathing gas passage and an external surface spaced from the interior surface of the housing to create a condensation passage. The baffle may be positioned between the breathing gas port and the input port to cause controlled condensation from the flow of humidified breathing gas by disrupting the flow of humidified breathing gas.

The present invention pertains to a system, method, and device for treating sleep disorders. The present invention is particularly useful in the delivery of carbon dioxide (CO2) to a subject and in the treatment of sleep apnea. Furthermore, integration of components with various sensors and apparatuses associated therewith and attached thereto preferably complete a rebreathing circuit in the present invention. In various embodiments of the present invention where the above components are integrated as a rebreathing circuit, a subject is both the source and recipient of a controlled concentration of carbon dioxide. In such embodiments, treatment of sleep disorders becomes much more efficient and effective.