An intraosseous needle includes a cylindrical shaft. The cylindrical shaft includes a first portion comprising a plurality of threads protruding from the cylindrical shaft. The cylindrical shaft includes a second portion comprising a plurality of fenestrations, disposed between the first portion and a distal end of the cylindrical shaft, wherein the cylindrical shaft is continuous and smooth within the second portion, and where the continuous, smooth second portion is longer than the first portion. The intraosseous needle also includes a needle head extending from a proximal end of the cylindrical shaft.

According to an embodiment, a painless syringe for reducing noise and friction caused when perforating an alveolar bone comprises an injecting part having a needle for perforating the alveolar bone and injecting an anesthetic, a holder having a first end coupled with the injecting part and a second end open and empty, an ampoule formed to be inserted into the holder and having a first end into which the needle of the injecting part is inserted and a second end having a piston for discharging the anesthetic, a housing formed to receive the holder and having a through hole to expose the first end of the holder to an outside, and a handpiece coupled with the housing, rotating the ampoule, the holder, and the injecting part to perforate the alveolar bone, and pressing the piston to inject the anesthetic.

The composition for bone regeneration, comprises a) a first phase (3) comprising a plurality of cross-linked hydrogel chunks (1) having a mean diameter of less than 1000 μm and incorporating an amount of mineral particles (2); and b) a second phase (4) comprising a physiologically-compatible aqueous liquid acting as a carrier for the chunks; the chunks being embedded in the second phase (4). The mineral particles (2) have a mean diameter of less than 10 μm and the amount of the mineral particles (2) is less than 20 weight-% of the first phase.

Disclosed herein are synthetic hydrogels suitable for delivering antimicrobial proteins, optionally in combination with bone regenerating agents to injured tissues. The hydrogels can include lysostaphin and one or more bone morphogenic proteins. The hydrogels are composed of a network of crosslinked hydrophilic polymers and adhesion peptides.

A method of treating a spinal disk according to the present invention can include inserting an alloplastic bulking agent into the spinal disk to treat the defect. The alloplastic bulking agent has a plurality of microparticles and a suspending agent comprising hyaluronic acid. The bulking agent results in at least one of sealing the defect, increasing a pressure of the disk, increasing a height of the disk, improving stability of the disk and improving structural integrity of the disk.

A device for collecting bone fragments includes a housing (512) and a filter element (522) disposed in the housing. The filter element has a first end (524), a second end (526), and a sidewall (528) that defines an inner peripheral (530) and outer peripheral (532) surface and includes a plurality of filter apertures (534). The inner peripheral surface at least partially defines a collection chamber (536) for collection of a composition comprising bone fragments. The outer peripheral surface of the sidewall and the housing are spaced apart from one another to define an exterior radial volume (540). The filter element also has a proximal portion (535) adjacent the second end (526) which defines at least one drain aperture (555). The composition is acquired and collected in the collection chamber with the exterior radial volume providing a primary fluid communication path with a vacuum source and the at least one drain aperture providing a supplementary fluid communication path with the vacuum source.

Inflatable medical devices and methods for making and using the same are disclosed. The inflatable medical devices can be medical balloons. The balloons can be configured to have a through-lumen or no through-lumen and a wide variety of geometries. The device can have a high-strength, non-compliant, fiber-reinforced, multi-layered wall. The inflatable medical device can be used for angioplasty, kyphoplasty, percutaneous aortic valve replacement, or other procedures described herein.

An intraosseous needle assembly includes a needle having a first cylindrical shaft. The shaft having a distal end, a proximal end, and a wall defining an inner channel. The first cylindrical shaft includes threading protruding from the wall along a proximal portion of the first cylindrical shaft. The needle further includes a needle head extending from the proximal end of the first cylindrical shaft. The needle assembly may further include a stylet, the stylet having a second cylindrical shaft having a first end and a second end and a stylet head extending from the second end. The stylet head includes a proximal surface and a distal surface, a pair of substantially parallel second side walls, a pair of rounded end sections joining the second side walls, a protrusion extending from the distal surface, and a tapered section extending from the distal surface to the second cylindrical shaft.

The invention relates to a device for applying a pharmaceutical fluid, having a tube and a valve element, wherein the tube can be connected in terms of fluid conduction via a first tube end to a reservoir for the pharmaceutical fluid, and wherein the valve element is arranged in a second tube end of the tube. The invention furthermore relates to a system for applying a pharmaceutical fluid, having a reservoir for the pharmaceutical fluid and such a device, and to a method for applying a pharmaceutical fluid by means of such a device.

System and methods for stimulating cartilage formation at a first tissue site through a second tissue site is presented. The system includes a fluid source for supplying a therapeutic solution, a reduced pressure source for supplying reduced pressure, a fluid delivery manifold for deploying adjacent the first tissue site, and a vacuum manifold for deploying within the second tissue site. The fluid delivery manifold extends between a proximal end fluidly coupled to the fluid supply and a distal end having at least one aperture for delivering the therapeutic solution to the defect adjacent the articulating surface of the first tissue site. The vacuum manifold extends between a proximal end fluidly coupled to the reduced pressure source and a distal end having at least one aperture for delivering the reduced pressure to the first tissue site adjacent the opposing surface of the first tissue site.