A method of method of high flow oxygen therapy (HFOT) and carbon dioxide (CO.sub.2) monitoring includes delivering high flow oxygen therapy (HFOT) via a central lumen of a nasal cannula, the nasal cannula comprising a proximal end, a distal end positioned within a pharynx region of a patient's airway, and the central lumen and a sampling lumen formed within a wall of the nasal cannula. The method also includes receiving sampled exhaled breath of the patient via the sampling lumen at a CO.sub.2 monitor, wherein the sampling lumen is configured to sample the exhaled breath at the pharynx region through the CO2-permeable membrane and direct the sampled exhaled breath to a CO.sub.2 monitor fluidly coupled to the sampling lumen and determining a level of CO.sub.2 in the exhaled breath using the CO.sub.2 monitor.

A device is provided for delivering a predetermined volume of at least one substance within a body cavity of a subject. The device contains a) a capsule for containing the predetermined volume of substances; b) a delivery end, having at least one orifice of diameter D, for placement in proximity to the body cavity; c) a valve mechanically connectable to the capsule, having at least two configurations: (i) an active configuration in which the valve enables delivery of the substances; and (ii) an inactive configuration, in which the valve prevents delivery of the substances from the capsule to the body cavity; and d) a fluid tight chamber configured to contain predetermined volume V.sub.gas of pressurized gas at a predetermined pressure, P.sub.gas. The capsule further contains at least one mixing mechanism that mixes the substances and the pressurized gas after the valve is reconfigured to the active configuration.

Systems and methods are provided for aerosolizing and delivering therapeutic substances in an electronic aerosol delivery device with airflow regulation. Calibrated airflow resistance settings enable adjustment and control of flow velocity and or flow volume of air, aerosolized air, and or entrained aerosol particles, through the device, for optimal aerosol delivery among diverse conditions and applications.

This invention relates to a voice therapy and vocal training device (1) which allows to perform both exhalation (phonation and breathing) and inhalation (humidifying and breathing) therapies and to humidify and treat vocal folds of a user. The aim of this invention is to provide a voice therapy and vocal training device (1) which aids in carrying out many features together (all-in-one) such as performing voice trainings, humidification of vocal folds, and being used as an inhalation and a spray device. The voice therapy and vocal training device (1) of the invention prevents water from going down the user's throat during inhalation thanks to its special design.

Described here are systems and methods for delivering an active agent to target tissues of the ear, nose, or throat using an expandable member having drug crystals layered thereon, and methods for manufacturing such systems. The expandable member can be delivered to the target tissues in a low-profile configuration and expanded to contact and/or dilate surrounding tissue. Expansion of the expandable member transfers the drug crystals to the target tissues, which then act as an in situ depot that enables maintenance of a therapeutic level of an active agent for a desired time period after removal of the expandable member. Multiple expansions of a single expandable member can be employed during treatment. For example, the systems and methods can be useful when it is desired to treat multiple paranasal sinuses with a single expandable member.

A portable device for treatment of migraine having a desktop unit defining an airpath through a desiccant, a heat sink, an air mover and an air outlet, and a tubeset including a tube having one end for connecting to the desktop air outlet and a second end connected to a handheld unit, the handheld unit including a water compartment, and a nebulizer/transducer for introducing water droplets into the air stream. A nasal pillow is provided at the end of the handheld unit for placing against a user's nose.

Methods and devices are provided for delivering one or more substances within at least one body cavity. Such devices include at least one nosepiece having at least one capsule including a volume V.sub.sub of the substances; at least one base in communication with the nosepiece, the base having at least one chamber configured to confine pressurized fluid at volume V.sub.PF and pressure P.sub.PF, and at least one hollow puncturing member having at least one sharp end and a second end in fluid communication with the base. The first and second ends are fluidly interconnected by at least one hollow tube. A fluid inlet port of the capsule is configured in terms of size and shape to interface in a sealable manner with at least one end of the at least one puncturing member.

A method of delivering a radioactive liquid includes, performing an initialization, including; extracting at least a first amount of a radioactive liquid from a source of radioactive liquid, measuring a radioactivity level for the first amount of radioactive liquid, and performing a calibration phase. The calibration phase includes, extracting a second amount of radioactive liquid from the source of radioactive liquid wherein the second amount is calculated based on the radioactivity level of the first amount to provide a total dose of radioactive liquid having a predetermined radioactivity level, and delivering the total dose and performing at least one more calibration and delivery phases.

In one embodiment, a device in a network detects an anomaly in the network by analyzing a set of sample data regarding one or more conditions of the network using a behavioral analytics model. The device receives feedback regarding the detected anomaly. The device determines that the anomaly was a true positive based on the received feedback. The device excludes the set of sample data from a training set for the behavioral analytics model, in response to determining that the anomaly was a true positive.

An example aerosol delivery device includes a mouthpiece having an airflow outlet, and an airflow passage extending between an airflow inlet and the airflow outlet. The example aerosol delivery device further includes a housing configured to receive a cartridge that includes an aerosolizable substance and a vapor element configured to heat the aerosolizable substance, and an internal power source configured to provide electrical power. The example aerosol delivery device further includes a controller coupled to the internal power source to receive a portion of the electrical power and configured to, when the cartridge is installed at the housing, cause the vapor element of the cartridge to heat the aerosolizable substance to release an aerosol into the airflow passage during an inhalation through the airflow outlet, and a connector configured to receive power from an external source to recharge the internal power source.