The invention relates to a patient interface comprising a plenum chamber, a seal-forming structure, and a positioning and stabilizing structure, as well as the method of operating the patient interface. The patient's interface is configured to leave a patient's mouth uncovered or if the seal-forming structure is configured to seal around a patient's nose and mouth, the patient interface is configured to allow the patient to breath from the ambient in an absence of the flow of pressurized. The positioning and stabilizing structure includes headgear, and the seal-forming structure and at least a portion of the headgear is formed from a one piece construction of textile material. In another embodiment, the seal-forming structure and/or the positioning and stabilizing structure includes an adaptive portion that adjusts based on usage conditions. In another embodiment, the positioning and stabilizing structure, the seal-forming structure and/or the plenum chamber includes and/or is formed of a textile material, and the textile material includes at least one magnetic thread constructed of magnetic material to provide a magnetic interaction between a first part of the patient interface and a second part of the patient interface. In another embodiment, a stiffener is coupled to the plenum chamber, the seal-forming structure, and/or the positioning and stabilizing structure. In another embodiment, at least one of the plenum chamber and the seal-forming structure includes a textile material; and wherein the textile material includes a surface structure that limits adhesion of debris. A UV cleaning receptacle of the patient interface is also disclosed.

Systems and methods are provided to combine multiple stimulation modalities to significantly increase the effectiveness of non-invasive stimulation. Multiple sensor and stimulation devices and modalities can be combined into a single, compact unit that minimizes the need for additional sensors or stimulation devices. The system features several subunits, referred to as sensory and stimulation devices (SSD), that are integrated into a headphone setup. The system is controlled by a centralized controller that communicates with all of the SSDs and with an external computer system that delivers learning material synchronized with the delivery of stimulations and the collection of user responses based on physiological signals.

An external ear canal pressure regulation device including a fluid flow generator and an earpiece having a first axial earpiece conduit fluidicly coupled to the fluid flow generator, whereby the earpiece has a compliant earpiece external surface configured to sealably engage an external ear canal as a barrier between an external ear canal pressure and an ambient pressure.

The present application includes a method for introducing a hormone directly into an affected area within a tumor. The method includes penetrating the affected area of the tumor with a biopsy needle in order to obtain a biopsy specimen. The specimen is withdrawn along with the biopsy needle. A hormone implant is inserted into the void space left behind as the specimen was removed. The method may also include directly inserting the implant and a treating substance into the tumor without the removal of the biopsy specimen. The implant may have various shapes in order to maximize surface contact. The implant is also configured to have a time release function to regulate dosage delivery.

Systems and methods discussed herein can be used to augment or induce brainwave behavior, such as using auditory stimulus, in an example, ambient acoustic information can be received, selectively modulated, and presented to a user in a substantially continuous manner. A low frequency portion of received ambient acoustic information can be modulated and then combined with a high frequency portion of the ambient acoustic information to produce a combined signal. The combined signal can be provided to the user as an auditory stimulation signal.

A bone conduction device including an external component, the external component comprising a sound processor and transducer, the transducer configured to generate mechanical forces, and the external component configured for positioning behind a recipient's ear such that the mechanical forces are transmitted from the external component to a recipient's bone to generate a hearing percept via bone conduction.

Some target anatomies within the ear, nose and/or throat of a patient may be difficult to access and treat. To provide a means of treating such target anatomies over time, drug delivery devices that are sized to be positioned within a naturally occurring or man-made anatomical cavity or passageway are preloaded with active agent(s). The drug delivery devices are affixed directly to, or in the vicinity of, a target anatomy. Once affixed, the drug delivery devices are configured to deliver active agent(s) at desired dosage(s) to the target anatomy through controlled elution of the active agent(s) as various structural features of the drug delivery devices are bio-eliminated.

A vestibular neurostimulation device, which may include first and second electrodes; first and second thermoelectric devices thermally coupled, respectively, to first and second earpieces that are configured to be insertable into respective ear canals of a patient; and a controller comprising a waveform generator. The waveform generator may be is configured to deliver a modulated electric signal to the patient through galvanic vestibular stimulation (GVS) using the first and second electrodes and to deliver a time varying thermal waveform to the patient through caloric vestibular stimulation (CVS) using the first and second earpieces simultaneous with the delivery of the modulated electrical signal through GVS. The CVS and/or GVS may be configured to increase a passage of insulin-like growth factor 1 (IGF-1) through a blood-brain-barrier.

A method of providing repetitive motion therapy comprising providing access to audio content; selecting audio content for delivery to a patient; performing an analysis on the selected audio content, the analysis identifying audio features of the selected audio content, and extracting rhythmic and structural features of the selected audio content; performing an entrainment suitability analysis on the selected audio content; generating entrainment assistance cue(s) to the selected audio content, the assistance cue(s) including a sound added to the audio content; applying the assistance cues to the audio content simultaneously with playing the selected audio content; evaluating a therapeutic effect on the patient, wherein the selected audio content continues to play when a therapeutic threshold is detected, and a second audio content is selected for delivery to the patient when a therapeutic threshold is not detected.

An ear drop applicator for the application of ear drops, which comprises a tray (3) for receiving a bottle of ear drops placed therein wherein the tray (3) comprises a spout (5) for inserting into an ear canal and through which the ear drops can pass from the bottle into the ear canal.