Delivery devices, systems, and methods related thereto may be used in humans for spinal delivery of cells, drugs or vectors. Thus, the system enables subpial delivery, which leads to a near complete spinal parenchymal AAV9-mediated gene expression or ASO distribution in both white and grey matter.

Personal thermal stability control herein provides for personalized temperature regulation dependent upon biometric sensor feedback, sleep stage, and so on, particularly for sleeping users, predicting and preemptively responding to fluctuations indicative of thermal stability, resulting from such things as transitions between sleep stages, hot flashes, night sweats, and general thermal instability. Specifically, in one embodiment, a system herein may comprise: an on-demand cooling system; one or more biometric sensors configured to monitor one or more corresponding indicators of thermal stability of a user; and a controller configured to: a) receive the one or more corresponding indicators of thermal stability of the user; b) predict an onset of a thermal instability of the user based on the one or more corresponding indicators of thermal stability of the user; and c) activate the on-demand cooling system to counteract the predicted onset of a thermal instability of the user.

An implantable glymphatic pump configured to flush metabolites from a brain parenchyma of a patient. The implantable glymphatic pump including at least one spinal catheter having a distal end configured to be positioned within an intrathecal space of a spine of a patient, at least one cranial catheter having a distal end configured to be positioned within a brain parenchyma of the patient, and an implantable pump configured to draw cerebrospinal fluid from the intrathecal space of the spine in the patient via the at least one spinal catheter, and reintroduce said cerebrospinal fluid to the brain parenchyma of the patient via the one or more cranial catheters to encourage a flow of the cerebrospinal fluid through the brain parenchyma.

The present disclosure describes a system for the delivery of therapeutic substances to the cavities of a patient. The system can include a wearable micropump that is fluidically coupled with a handpiece. The handpiece can be inserted, for example, into the middle ear via a surgical tympanotomy approach. The system can enable a controlled injection of a therapeutic substance directly into the patient's cavity.

A method of delivering a therapeutic agent to a nucleus pulposus of an intervertebral disc is provided. The method comprises inserting a delivery tool containing the therapeutic agent through an anterior portion, a lateral portion, or an anterolateral portion of an annulus fibrosus and into the nucleus pulposus of the intervertebral disc; and delivering the therapeutic agent to the nucleus pulposus of the intervertebral disc. Devices and kits are also provided.

An apparatus and method use a catheter for specific and discriminate treatment of central nervous system disease. With the catheter, selective hypothermia to the brain and/or the spinal cord for injury protection can be achieved without the need for systemic cooling. The catheter is also capable of draining excess cerebrospinal fluid.

The disclosed systems and methods are configurable central nervous system (CNS) delivery solutions for therapeutics, such as genetic medicines. The systems and methods first infuse a therapeutic bolus within intrathecal space and subsequently infuse a flush fluid to move the therapeutic bolus rostrally toward a target area and achieve a desired spread in the spine and/or brain. The second location can be at a location caudal to the delivery location of the therapeutic bolus.

An apparatus includes an elongated body having a tapered distal end and a proximal end that are aligned along an axis; first and second electrical sensors disposed on the elongated body; an injection port on the elongated body between the first and second electrical sensors; a power source electrically coupled to the first and second electrical sensors; a computer having an input electrically coupled to the first and second electrical sensors to receive first and second output signals, respectively, from the first and second electrical sensors. The computer is configured to analyze an electrical characteristic measured by the first and second electrical sensors; and produce an output control signal when the electrical characteristic measured by the first and second electrical sensors indicates that the injection port is aligned with a target anatomical feature.

The present disclosure generally relates to a system for flowing a fluid, e.g., CSF, from a body of a patient for sampling and analysis. In some embodiments, the system can include a diagnostic module having one or more conduits for flowing fluid therethrough. The flow of the fluid through the valves can be regulated using a control board that changes an orientation of valves disposed in the conduits between a dead-end orientation and a flow-through orientation to sample and/or analyze the fluid from the system. In some embodiments, the fluid can be recirculated into the system through one or more of the valves, with sampling and recirculating occurring substantially simultaneously.

A method and apparatus for treating a synovial cyst is disclosed. The method includes determining a presence and location of a cyst within a body, penetrating the cyst through a penetration bore to release a synovial fluid accumulation from within the cyst. A suction is applied to the cyst to via the penetration bore to extract a volume of the fluid accumulation from within the cyst. A weeping tube is inserted in the penetration bore to communicate synovial fluid from the cyst to maintain the cyst in a depressed condition for a predetermined temporal period. The weeping tube an external sidewall and an interior channel configured to communicate a synovial fluid from the synovial cyst. A plurality of protrusions about the external sidewall engage with a body tissue surrounding a penetration bore in the body tissue to retain the weeping tube at a desired placement within the penetration bore.