Various embodiments disclosed relate to drug-coated balloon catheters for treating, preventing, or reducing the recurrence of a stricture and/or cancer, or for treating benign prostatic hyperplasia (BPH), in a non-vascular body lumen and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent. In some embodiments, the balloon catheter includes a length-control mechanism which stretches and elongates the balloon when it is in a deflated state, giving the balloon a smaller cross-sectional deflated profile for tracking through the body lumen and for removal after treatment.

Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface. In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent. In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent.

A double-balloon catheter device for gastrointestinal anastomosis. The double-balloon catheter device for gastrointestinal anastomosis includes a liquid injection assembly, a double-balloon assembly, and a supporting device (15) connecting the liquid injection assembly and the double-balloon assembly. The liquid injection assembly includes a first balloon liquid injection connection port (2), a guide wire connection port (3), and a second balloon liquid injection connection port (4). The double-balloon assembly includes a double-balloon catheter device (5), and includes a first balloon (6) and a second balloon (7) that can expand-and that are respectively disposed on the two ends of the double-balloon catheter device (5). The double-balloon catheter device (5) is provided with a first balloon liquid injection channel (51), a guide wire channel (52), and a second balloon liquid injection channel (53).

The present invention provides an automatic drug delivery device. The automatic drug delivery device includes an enclosure and a first piston disposed in the enclosure. The first piston partitions the enclosure to a first drug delivery chamber and a first expansion chamber. A first through hole and a second through hole are formed in the wall of the enclosure, the first through-hole communicates with the first drug delivery chamber, and the second through-hole communicates with the first expansion chamber. A first targeted dissolution membrane covers the first through hole and the second through hole, and dissolves at a first targeted region. A drug is filled in the first drug delivery chamber, and an expandable material is included in the first expansion chamber. The expandable material in the first expansion chamber can expand after absorbing liquid.

Various embodiments disclosed relate to drug-coated balloon catheters for treating, preventing, or reducing the recurrence of a stricture and/or cancer, or for treating benign prostatic hyperplasia (BPH), in a non-vascular body lumen and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent. In some embodiments, the balloon catheter includes a length-control mechanism which stretches and elongates the balloon when it is in a deflated state, giving the balloon a smaller cross-sectional deflated profile for tracking through the body lumen and for removal after treatment.

Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

There is provided a colon cleaning device comprising: a tube through which liquid and fecal matter are removed from a colon of a patient, the tube having a longitudinal axis; a cleaning head positioned at the distal end of the tube, the cleaning head having at least one opening coaxial with the longitudinal axis, the at least one opening sized for fecal matter to enter the interior of the cleaning head from the colon; at least one disassembly element disposed within the cleaning head; and an actuating mechanism which actuates the disassembly element to perform sweeping displacement inside the cleaning head so that the at least one disassembly element rotates around the longitudinal axis to slice through the fecal matter; wherein the cleaning head and the tube are sized and shaped to be displaced along the colon of a patient.

Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface. The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage with a surface. In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components.

Disclosed is a two-way vacuum assisted closure system in the medical field which eliminates leakages based on the upper gastrointestinal system organs such as the stomach and intestine after stab wounds and/or wounds after surgical operations.

Provided is a method of cleaning a body cavity using a device by coupling a distal end portion of a first cannula to the housing such that a lumen is in fluid communication with the first portion of the inner volume, the first cannula coupled to a vacuum source, then coupling a distal end portion of a second cannula to the housing such that a lumen is in fluid communication with the second portion of the inner volume, the second cannula being coupled to a fluid source, inserting a portion of the housing into a body cavity, conveying a fluid from the fluid source to the body cavity via the lumen of the second cannula, and withdrawing the fluid from the body cavity into the vacuum source concurrently with the conveying the fluid, via the lumen of at least the first cannula.