The disclosure provides methods that facilitate disease management by providing for early detection of metabolic changes that differentiate critically ill-COVID-19 patients under mechanical ventilation at the intensive care unit (ICU) who are likely to exhibit faster recovery.

The present invention relates to a portable lung assist device. In one embodiment, the portable lung assist device comprises an integrated oxygenator, blood pump, and cannula. In one embodiment, the portable lung assist device of the present invention does not require an oxygen tank, but instead can provide oxygen to a subject's blood from ambient air. In one embodiment, at least a portion of the portable lung assist device, for example the cannula can be implantable. In one embodiment, the cannula of the device of the present invention can be inserted in to the subject's pulmonary artery. A method for providing portable lung assistance is also described.

A device and method of generating an enriched gas within a nasal vestibule of a patient includes a housing, a chamber, a chamber inlet, a pump, a molecular sieve bed, a release outlet, and a breath duct. The chamber is configured to be received within the nasal vestibule. The pump is configured to direct an ambient air from an ambient environment into the chamber. The molecular sieve bed is positioned within the chamber and configured to collect a predetermined molecule from the ambient air thereby generating the enriched gas. The release outlet is configured to discharge the enriched gas from the chamber into the nasal vestibule. The breath duct longitudinally extends through the housing such that the breath duct is configured to fluidly communicate a fluid flow through the housing for nasal breathing by the patient while the chamber is positioned within the nasal vestibule.

Systems and methods are provided for optimizing hemodynamics within a patient's heart, e.g., to improve the patient's exercise capacity. In one embodiment, a system is configured to be implanted in a patient's body to monitor and/or treat the patient that includes at least one sensor configured to provide sensor data that corresponds to a blood pressure within or near the patient's heart; at least one component designed to cause dyssynchrony of the right ventricle, and a controller configured for adjusting the function of the at least one component based at least in part on sensor data from the at least one sensor.

Apparatus and methods are described including a blood pump that includes a catheter, a first impeller disposed on the catheter, and a second impeller disposed on the catheter, proximally to the first impeller. A motor drives the first and second impellers to pump blood of a subject, by driving the first and second impellers to rotate. The blood pumps is configured such that (a) the first and second impellers are shaped differently from each other when the first and second impellers are in non-radially-constrained configurations, (b) the first and second impellers are sized differently from each other when the first and second impellers are in non-radially-constrained configurations, and/or (c) the first and second impellers are driven by the motor to rotate under respective rotation conditions that are different from each other. Other applications are also described.

Devices, systems, and methods for monitoring respiration using surface temperature, humidity, air pressure, carbon dioxide gas sensors, pulse oximetry sensors and electromyography sensors, and/or acceleration sensors to obtain information related to respiration rate (RR), exhalation/inhalation strength, exhalation/inhalation volume, exhalation/inhalation acceleration, and/or exhalation/inhalation regularity.

An overdose of opioids can cause the user to stop breathing, resulting in death. A physiological monitoring system monitors respiration based on oxygen saturation readings from a fingertip pulse oximeter in communication with a smart mobile device and sends opioid monitoring information from the smart mobile device to an opioid overdose monitoring service. The opioid overdose monitoring service notifies a first set of contacts when the opioid monitoring information.

An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysate circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid; a control unit (12) is configured for receiving a conductivity or sodium concentration set point for the dialysis fluid and for calculating a mass transport of a substance at an instant t of a treatment session based on said set value of the parameter for the dialysis fluid in the dialysis supply line (8).

Systems and methods are provided remotely controlling a medical device. In some embodiments, systems and methods are also provided for remote medical monitoring. This includes, for example, emergency/panic notifications/functions, medical event recording, compliance monitoring, sleep timer and environmental controls, two-way communication, and other functions such as, for example, emergency telephony/communication in various forms. In other embodiments, systems and methods for managing a remote control of a medical device are provided. This includes, for example, two-way communication for assisting in locating the remote, power management including sleep mode and wireless charging, and master remote/key functionality. The remote can be handheld or wearable and may include, for example, audio, visual, haptic, input, communication, and sensor (including biosensor) functionality and outputs. In this manner, the remote control can not only control the medical device, but also provides the user with extended functionality for emergency and non-emergency communication and tasks.

A super enriched personal oxygen concentrator system that discards argon as waste, including a personal oxygen concentrator operatively attached to a first bed for absorbing nitrogen and second bed for absorbing oxygen, and an argon waste outlet operatively attached to the first and second beds for eliminating argon from the system. A method of using the system of the present invention, by absorbing nitrogen from compressed air from a POC with a first bed, absorbing oxygen with a second bed, discarding unabsorbed argon from the compressed air as waste, desorbing enriched oxygen product, and providing a 99% oxygen product. A fluid supply warning and communication system, wherein a primary fluid reservoir is connected to the personal oxygen concentrator system. A method of using the fluid supply warning and communication system.