Various embodiments disclosed relate to drug-coated balloon catheters for treating, preventing, or reducing the recurrence of a stricture and/or cancer, or for treating benign prostatic hyperplasia (BPH), in a non-vascular body lumen and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent. In some embodiments, the balloon catheter includes a length-control mechanism which stretches and elongates the balloon when it is in a deflated state, giving the balloon a smaller cross-sectional deflated profile for tracking through the body lumen and for removal after treatment.

Inflatable medical devices and methods for making and using the same are disclosed. The devices can be medical invasive balloons, such as those used for transcutaneous heart valve implantation, such as balloons used for transcatheter aortic-valve implantation. The balloons can have high strength, fiber-reinforced walls.

Medical devices including balloons and balloons are provided that include an elongate body and an inflatable balloon defining a longitudinal axis, the inflatable balloon being attached to and partially surrounding at least a section of the elongate body. The medical device further includes a plurality of protrusions extending from the inflatable balloon. When the inflatable balloon is in an unstrained state, each of the plurality of protrusions extends in a first transverse direction relative to the longitudinal axis. In certain implementations, the inflatable balloon may also be configured to collapse such that, when in a collapsed state, an untextured portion of the inflatable balloon extends to a radius and the plurality of protrusions does not extend beyond the radius.

The invention relates to a method for filling an inflatable catheter balloon of a device for transanally introducing an infusion into the rectum or colon of a patient by means of a filling device, wherein a fill volume or a filling pressure prevailing in the catheter balloon is increased in two or more steps until there occurs a gradual, user-controllable, pneumatically initiated expansion of portions of the bowel wall, thus triggering a coordinated defecation reflex, wherein the timing and intensity of the triggering stimulus can be determined to the greatest possible extent by the user.

The invention relates to a medical device, the medical device comprising a balloon catheter, a first stent, and a second stent; the balloon catheter having a shaft and an inflatable balloon mounted to the shaft at the distal end the balloon having a distal portion having a first outer diameter and a proximal portion having a second outer diameter, wherein the first diameter is smaller than the second diameter and a transition region located between the distal portion and the proximal portion, a first stent having a first nominal diameter mounted on the distal portion of the balloon and a second stent having a second nominal diameter mounted on the proximal portion of the balloon, a distal portion of the second stent overlapping a proximal portion of the first stent, wherein the proximal end of the first stent is positioned proximal to the distal end of the second stent, the medical device further comprising a pre-cannulation means providing a passage from the interior of the second stent to the exterior of the first stent passing the stent overlapping portion between the inner surface of the second stent and the outer surface of the first stent.

Systems (1100) for treating a blood flow passage are discloses herein. In one example, a treatment device includes an expandable element (1104) configured to be positioned within the passage and a reinforcing element (1102). The expandable element may have an expanded configuration in which the expandable element defines a lumen (1108) therethrough. The reinforcing element may be positioned within the lumen of the expandable element. The reinforcing element may be coupled to the expandable element such that expansion of the expandable element causes the reinforcing element to radially expand, thereby creating a perfusion lumen through the device.

An ostial stent delivery device may include a first elongate shaft including a first lumen and extending along a central longitudinal axis, wherein the first elongate shaft includes a first inflatable balloon fixedly attached proximate a distal end of the first elongate shaft; and a second elongate shaft including a second lumen, the first elongate shaft being at least partially disposed within the second lumen. The second elongate shaft includes a second inflatable balloon fixedly attached proximate a distal end of the second elongate shaft. The second inflatable balloon is disposed at least partially proximal of the first inflatable balloon. The first inflatable balloon has a substantially cylindrical shape along a majority of its length in the deployed configuration. The second inflatable balloon has a substantially biconical shape having a central axis oriented parallel to the central longitudinal axis in the deployed configuration.

A method is disclosed, including joining a balloon to a resilient inner body of a balloon assist device, the balloon comprising an axial length shorter than an axial length of the inner body; expanding a slit in the resilient inner body of the balloon assist device; inserting a catheter through the slit; and releasing the slit to contract the balloon assist device around the catheter.

Sinusitis and other disorders of the ear, nose and throat are diagnosed and/or treated using minimally invasive approaches with flexible or rigid instruments. Various methods and devices are used for remodeling or changing the shape, size or configuration of a sinus ostium or duct or other anatomical structure in the ear, nose or throat; implanting a device, cells or tissues; removing matter from the ear, nose or throat; delivering diagnostic or therapeutic substances or performing other diagnostic or therapeutic procedures. Introducing devices (e.g., guide catheters, tubes, guidewires, elongate probes, other elongate members) may be used to facilitate insertion of working devices (e.g. catheters e.g. balloon catheters, guidewires, tissue cutting or remodeling devices, devices for implanting elements like stents, electrosurgical devices, energy emitting devices, devices for delivering diagnostic or therapeutic agents, substance delivery implants, scopes etc.) into the paranasal sinuses or other structures in the ear, nose or throat. Specific devices (e.g., tubular guides, guidewires, balloon catheters, tubular sheaths) are provided as are methods for manufacturing and using such devices to treat disorders of the ear, nose or throat.

One aspect of the invention provides a balloon catheter having a distal tip that does not extend distally beyond the distal end of the catheter balloon when the catheter balloon is inflated. In one embodiment, the distal end of the catheter balloon has a substantially flat profile when inflated. Other aspects of the invention provide methods of manufacturing and of using the balloon catheter. In one embodiment, the balloon catheter is used in the treatment of kidney stones.