An inflation device includes a balloon and a shaft coupled to one another via an overmold that includes a shut-off ridge. The shaft is in pressure communication with the balloon. Therefore, when fluid pressure is increased in the shaft the balloon may inflate. The use of shut-offs to form the overmold including shaping the shut-off ridge should result in an overmold with no flash and few or no bubbles within its structure.

Providing a method for producing a balloon catheter, that is capable of uniformly heating and cooling the entire mold and less likely to cause temperature unevenness. A method for producing a balloon catheter which comprises a shaft extending in a longitudinal direction and a medical resin balloon provided at a distal end portion of the shaft, comprising the steps of inserting a resin tubular body (10) into a mold (20), and placing the mold (20) inside a thermal jacket (30) wherein a porous metal body (50) is disposed outside the mold (20) and inside the thermal jacket (30).

One aspect of the invention provides a balloon catheter having a distal tip that does not extend distally beyond the distal end of the catheter balloon when the catheter balloon is inflated. In one embodiment, the distal end of the catheter balloon has a substantially flat profile when inflated. Other aspects of the invention provide methods of manufacturing and of using the balloon catheter. In one embodiment, the balloon catheter is used in the treatment of kidney stones.

A method of manufacturing includes forming a medical balloon with a scoring element along at least a barrel section by expanding a tubular parison in a mold cavity including a closed end groove corresponding to the scoring element. The scoring element may extend longitudinally, circumferentially, or helically, and a plurality of scoring elements may be provided. Medical balloons formed using the method and a mold for forming such balloons are also disclosed.

A medical catheter includes a multi-lumen tube including a first lumen and a second lumen; an extension tube fixed to an end surface in a longitudinal direction of the multi-lumen tube, extending from the end surface along the longitudinal direction, and including a third lumen communicating with the first lumen; and an outer wall portion extending from the multi-lumen tube along the extension tube and configured to cover a part of an outer surface of the extension tube, the outer wall portion including a pipeline formed to communicate with the second lumen and having a part of the outer surface in an inner surface of the pipeline.

The present disclosure provides a catheter assembly including a catheter tube and an expandable unit attached to the catheter tube. The expandable unit is configurable in a collapsed configuration for facilitating delivery of the catheter assembly through a body lumen and a fully expanded configuration for contacting an interior wall of the body lumen to cover a perforation. The expandable unit defines a longitudinal channel extending from a proximal end to a distal end of the expandable unit when in the fully expanded configuration, permitting blood flow past the expandable unit. The disclosure further provides a method of treating a perforation by delivering a catheter assembly with an expandable unit to a perforation site, expanding the expandable unit to contact an interior wall of a body lumen to cover the perforation, and permitting blood flow past the expandable unit while in contact with the interior wall covering the perforation.

Compositions and methods of using them to protect an animal cell or tissue from a microbial pathogen are described. The compositions can include one or more natural oils or extracts comprising a therapeutically active compound to protect the cell or tissue of the animal from the microbial pathogen by direct inactivation of the microbial pathogen or by blocking the microbial pathogen entrance to the animal cell or tissue. Oil macerates that include a therapeutically active compound extracted from plants are also described.

Catheter assemblies and methods for making and using catheter assemblies are disclosed. An example a catheter assembly includes a catheter shaft and a balloon attached to the catheter shaft. The balloon includes a body and a proximal waist portion. The proximal waist portion has a proximal end. The catheter assembly also has a fiber braid including one or more individual filaments disposed along the balloon. The fiber braid has a proximal end aligned with the proximal end of the waist portion. The catheter assembly also has a polymer sleeve disposed on the catheter shaft, wherein in the polymer sleeve abuts the proximal end of the balloon waist and the proximal end of the braid.

The invention discloses an auxiliary balloon structure for transcatheter aortic valve replacement (TAVR), which comprises a balloon head and a balloon body. When unexpanded, the balloon body has two conical ends and a cylindrical middle part. The conical ends are defined as a front and a rear conical part. The cylindrical middle part is provided with a mastoid structure. The front and rear conical parts are made of a semi-compliant material, while the cylindrical middle part is made of a non-compliant material.

In various embodiments, a device is provided comprising a balloon configured to expand to an expanded state in response to introduction of a fluid at a first pressure, wherein the fluid perfuses through the balloon above a second pressure, the second pressure being the same or greater than the first pressure. In various embodiments, a method comprising fabricating a balloon configured to expand to an expanded state in response to introduction of a fluid at a first pressure, wherein the fluid perfuses through the balloon above a second pressure, the second pressure being at or greater than the first pressure, disposing the balloon on an elongate member having a lumen, placing the lumen in fluid communication with an interior volume of the balloon.